Fenspiride - CAS 5053-06-5
Catalog number:
5053-06-5
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C15H20N2O2
Molecular Weight:
260.34
COA:
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Targets:
Adrenergic Receptor | Histamine Receptor
Description:
Fenspiride is an α adrenergic and H1 histamine receptor antagonist. It is an oxazolidinone spiro compound. It is used as a drug in the treatment of certain respiratory diseases. It is also used for the treatment of acute and chronic inflammatory diseases of ENT organs and the respiratory tract, as well as for maintenance treatment of asthma in Russia. It has been listed.
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Purity:
> 95%
Appearance:
Solid powder
Synonyms:
Respiride;Viarespan;JP428;JP-428;NAT-333;NAT333;NDR-5998A;NDR5998A;Decaspiride;Espiran;8-(2-Phenylethyl)-1-oxa-3,8-diazaspiro(4.5)decan-2-one;1-Oxa-3,8-diazaspiro[4.5]decan-2-one, 8-(2-phenylethyl)-
Solubility:
Soluble in DMSO, not in water
Storage:
-20°C Freezer
MSDS:
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Application:
Fenspiride is used as a drug in the treatment of certain respiratory diseases. It is also used for the treatment of acute and chronic inflammatory diseases of ENT organs and the respiratory tract, as well as for maintenance treatment of asthma.
Quality Standard:
In-house standard
Quantity:
Kilograms to Tons
Boiling Point:
126-127 °C | Condition: Press: 2 Torr
Melting Point:
235-238°C
Density:
1.19±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
FVNFBBAOMBJTST-UHFFFAOYSA-N
InChI:
InChI=1S/C15H20N2O2/c18-14-16-12-15(19-14)7-10-17(11-8-15)9-6-13-4-2-1-3-5-13/h1-5H,6-12H2,(H,16,18)
Canonical SMILES:
C1CN(CCC12CNC(=O)O2)CCC3=CC=CC=C3
Current Developer:
Fenspiride has been listed.
1.[The efficacy of application of fenspiride (erespal) for the treatment of exacerbation of bronchial asthma in children].
Lebedenko AA1, Mal'tsev SV. Vestn Otorinolaringol. 2011;(4):66-7.
The objective of the present study was to estimate the efficacy and safety of combination of anti-inflammatory treatment of bronchial asthma (BA) and therapy with erespal. A total of 57 children aged from 6 to 14 years were available for the observation. They presented with mild intermittent (n=27), mild persisting (n=20), and moderately severe (n=10) forms of the disease. The traditional treatment of all the patients was supplemented by daily intake of erespal syrup at a dose of 4 mg/kg b.w. from the first day after admission to the hospital. It is concluded based on the results of the study that the use of erespal reduces the duration of the disease and the time of recovery of bronchial patency; also, it accelerates the process of arterial blood saturation with oxygen.
2.[Pathogenetic correction of postoperative inflammation in modern rhinosurgery].
Kim IA, Nosulia EV. Vestn Otorinolaringol. 2010;(4):78-81.
This study included 20 patients presenting with polypous rhinosinusitis examined before and after endoscopic intervention in the nasal cavity and paranasal sinuses. Nitric oxide (NO) content in nasal secretion and polypoid tissue was estimated from the concentration of nitrates that, together with nitrites, are the final products of oxidation of nitric oxide and serve as markers of endogenous NO. Nitrates in the nasal secretion, endonasal mucosa, and polypous tissue were determined by the ionometric technique. Their content was additionally measured in 12 subjects without polypous rhinosinusitis. The nasal secretion and polypous tissue of PRS patients were found to contain nitrates at a higher concentration compared with healthy subjects. Nitrate concentrations in the nasal secretion and polypous tissue of PRS patients were not significantly different. Mean saccharine transport time in the nasal cavity of the patients with an elevated level of nitrates in the nasal secretion was significantly higher than in PRS patients with the lowered nitrate levels.
3.[The assessment of the effectiveness of fenspiride (erespal) for the combined treatment of the patients presenting with exudative otitis media].
Mel'chinskiĭ AN, Vasilenko DIu, Kiseleva GV. Vestn Otorinolaringol. 2013;(6):70-1.
The objective of the present work was to estimate the effectiveness and safety of combined anti-inflammatory therapy of exudative otitis media with the use of fenspiride (erespal). The study included 75 patients of whom 35 (group 1) were given standard therapy supplemented by erespal (80 mg thrice daily); the remaining patients receiving standard therapy alone formed group 2 (control). The patients treated with erespal reported the subjective improvement of hearing and reduced congestion on days 7 - 8. Similar changes in group 2 occurred on day 10. It is concluded that the use of erespal for the combined treatment of the patients presenting with exudative otitis media reduces the duration of hospital stay, accelerates recovery, and promotes rapid normalization of hearing.
4.[The use of eurespal for the treatment of chronic laryngitis].
Riabova MA. Vestn Otorinolaringol. 2011;(1):70-3.
The author provides a rationale for the use of eurespal for the treatment of chronic laryngitis based on the pathogenetic concept of pathological condition. The results of a clinical study designed to evaluate the efficiency and safety of eurespal therapy in patients with chronic laryngitis are presented.
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CAS 5053-06-5 Fenspiride

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