Fenoldopam Mesylate - CAS 67227-57-0
Catalog number: 67227-57-0
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C17H20ClNO6S
Molecular Weight:
401.86
COA:
Inquire
Targets:
Dopamine Receptor
Description:
Fenoldopam is a selective D1 receptor partial agonist, binds to α2-adrenoceptors, increasing renal blood flow used as an antihypertensive agent.
Purity:
≥98%
Appearance:
White to Off-White Solid
Synonyms:
6-Chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-1H-3-benzazepine-7,8-diol; Methanesulfonate; Corlopam; Fenoldopam Methanesulfonate; Fenoldopam Monomethanesulfonate; SKF 82526J;
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
Dopamine D1-receptor agonist. Antihypertensive.
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Grams-Kilos
Melting Point:
263-269 °C (dec.)
Density:
1.38g/cm3
InChIKey:
CVKUMNRCIJMVAR-UHFFFAOYSA-N
InChI:
1S/C16H16ClNO3.CH4O3S/c17-15-11-5-6-18-8-13(9-1-3-10(19)4-2-9)12(11)7-14(20)16(15)21;1-5(2,3)4/h1-4,7,13,18-21H,5-6,8H2;1H3,(H,2,3,4)
Canonical SMILES:
CS(=O)(=O)O.C1CNCC(C2=CC(=C(C(=C21)Cl)O)O)C3=CC=C(C=C3)O
Current Developer:
GlaxoSmithKline
1.Fenoldopam to prevent acute kidney injury after major surgery-a systematic review and meta-analysis.
Gillies MA1, Kakar V2, Parker RJ3, Honoré PM4, Ostermann M5. Crit Care. 2015 Dec 25;19(1):449. doi: 10.1186/s13054-015-1166-4.
BACKGROUND: Acute kidney injury (AKI) after surgery is associated with increased mortality and healthcare costs. Fenoldopam is a selective dopamine-1 receptor agonist with renoprotective properties. We conducted a systematic review and meta-analysis of randomised controlled trials comparing fenoldopam with placebo to prevent AKI after major surgery.
2.Inhibitory effect of D1-like dopamine receptors on neuropeptide Y-induced proliferation in vascular smooth muscle cells.
Zhou Y1,2,3, Shi W1,2, Luo H1,2, Yue R1,2, Wang Z1,2, Wang W1,2, Liu L1,2, Wang WE1,2, Wang H1,2, Zeng C1,2. Hypertens Res. 2015 Dec;38(12):807-12. doi: 10.1038/hr.2015.84. Epub 2015 Jul 16.
Proliferation of vascular smooth muscle cells (VSMCs) is thought to have a key role in the development of atherosclerotic lesions. Neuropeptide Y (NPY), norepinephrine and dopamine are sympathetic neurotransmitters. NPY has been particularly shown to stimulate proliferation of VSMCs. NPY, norepinephrine and dopamine are all sympathetic transmitters. In our previous study, we found that in the presence of the dopamine receptor, the α1-adrenergic receptor-mediated VSMC proliferation is reduced. We hypothesize that the activation of the D1-like receptor might inhibit the NPY-mediated VSMC proliferation. In our present study, we found that NPY, mainly via the Y1 receptor, increased VSMC proliferation. This was determined by [(3)H]-thymidine incorporation, in a concentration (10(-11) to 10(-8)  M)-dependent manner. In the presence of the D1-like receptor agonist, fenoldopam (10(-12) to 10(-5) M), the stimulatory effect of NPY on VSMC proliferation was reduced.
3.THE EFFECTS OF FENOLDOPAM ON RENAL FUNCTION AND METABOLISM IN AN OVINE MODEL OF SEPTIC SHOCK.
Post EH1, Su F, Taccone FS, Hosokawa K, Herpain A, Creteur J, Vincent JL, De Backer D. Shock. 2016 Apr;45(4):385-92. doi: 10.1097/SHK.0000000000000516.
INTRODUCTION: The importance of renal perfusion and metabolism in septic acute kidney injury (AKI) remains unclear. Prophylactic administration of the dopaminergic agent, fenoldopam, has been suggested to reduce the occurrence of AKI, but its effects in septic shock are poorly defined.
4.Dopamine D1-Like Receptors Suppress the Proliferation of Macrophages Induced by Ox-LDL.
Yao Y1, Yang D, Han Y, Wang W, Wang N, Yang J, Zeng C. Cell Physiol Biochem. 2016;38(1):415-26. doi: 10.1159/000438640. Epub 2016 Jan 29.
BACKGROUND/AIMS: Oxidized low-density lipoprotein (Ox-LDL) induces macrophage proliferation, a key physiological process which leads to atherosclerosis. The aim of this study was to determine the effects of dopamine D1-like receptors on macrophage proliferation induced by Ox-LDL.
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CAS 67227-57-0 Fenoldopam Mesylate

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