Fenoldopam - CAS 67227-56-9
Catalog number: 67227-56-9
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C16H16ClNO3
Molecular Weight:
305.76
COA:
Inquire
Targets:
Dopamine Receptor
Description:
Fenoldopam is a selective D1 receptor partial agonist, binds to α2-adrenoceptors, increasing renal blood flow used as an antihypertensive agent.
Purity:
≥98%
Appearance:
Solid Powder
Synonyms:
9-chloro-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol;SKF 82526; SKF82526; SKF-82526
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
A selective D1 receptor partial agonist, binds to α2-adrenoceptors
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
InChIKey:
TVURRHSHRRELCG-UHFFFAOYSA-N
InChI:
1S/C16H16ClNO3/c17-15-11-5-6-18-8-13(9-1-3-10(19)4-2-9)12(11)7-14(20)16(15)21/h1-4,7,13,18-21H,5-6,8H2
Canonical SMILES:
C1CNCC(C2=CC(=C(C(=C21)Cl)O)O)C3=CC=C(C=C3)O
Current Developer:
GlaxoSmithKline
1.The pharmacokinetics of intravenous fenoldopam in healthy, awake cats.
O'Neill KE1, Labato MA2, Court MH3. J Vet Pharmacol Ther. 2016 Apr;39(2):202-4. doi: 10.1111/jvp.12274. Epub 2016 Jan 14.
Fenoldopam is a selective dopamine-1 receptor agonist that improves diuresis by increasing renal blood flow and perfusion and causing peripheral vasodilation. Fenoldopam has been shown to induce diuresis and be well-tolerated in healthy cats. It is used clinically in cats with oliguric kidney injury at doses extrapolated from human medicine and canine studies. The pharmacokinetics in healthy beagle dogs has been reported; however, pharmacokinetic data in cats are lacking. The goal of this study was to determine pharmacokinetic data for healthy, awake cats receiving an infusion of fenoldopam. Six healthy, awake, client-owned cats aged 2-6 years old received a 120-min constant rate infusion of fenoldopam at 0.8 μg/kg/min followed by a 20-min washout period. Ascorbate stabilized plasma samples were collected during and after the infusion for the measurement of fenoldopam concentration by HPLC with mass spectrometry detection. This study showed that the geometric mean of the volume of distribution, clearance, and half-life (198 mL/kg, 46 mL/kg/min, and 3.
2.Fenoldopam to prevent acute kidney injury after major surgery-a systematic review and meta-analysis.
Gillies MA1, Kakar V2, Parker RJ3, Honoré PM4, Ostermann M5. Crit Care. 2015 Dec 25;19:449. doi: 10.1186/s13054-015-1166-4.
BACKGROUND: Acute kidney injury (AKI) after surgery is associated with increased mortality and healthcare costs. Fenoldopam is a selective dopamine-1 receptor agonist with renoprotective properties. We conducted a systematic review and meta-analysis of randomised controlled trials comparing fenoldopam with placebo to prevent AKI after major surgery.
3.THE EFFECTS OF FENOLDOPAM ON RENAL FUNCTION AND METABOLISM IN AN OVINE MODEL OF SEPTIC SHOCK.
Post EH1, Su F, Taccone FS, Hosokawa K, Herpain A, Creteur J, Vincent JL, De Backer D. Shock. 2016 Apr;45(4):385-92. doi: 10.1097/SHK.0000000000000516.
INTRODUCTION: The importance of renal perfusion and metabolism in septic acute kidney injury (AKI) remains unclear. Prophylactic administration of the dopaminergic agent, fenoldopam, has been suggested to reduce the occurrence of AKI, but its effects in septic shock are poorly defined.
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CAS 67227-56-9 Fenoldopam

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