Felodipine - CAS 72509-76-3
Not Intended for Therapeutic Use. For research use only.
Product Name:
Catalog Number:
Plendil; Flodil; Munobal; Renedil
CAS Number:
Felodipine is a selective L-type Ca2+ channel blocker with IC50 of 0.15 nM. It can lower blood pressure by reducing peripheral vascular resistance via a highly selective effect on smooth muscle in arteriolar resistance vessels.
Molecular Weight:
Molecular Formula:
Canonical SMILES:
Calcium Channel
Catalog Number Size Price Stock Quantity
B0084-075974 5 g $298 In stock
Bulk Inquiry
Chemical Structure
CAS 72509-76-3 Felodipine

Related Calcium Channel Products

CAS 144604-00-2 Diltiazem Malate

Diltiazem Malate
(CAS: 144604-00-2)

Diltiazem is a calcium channel antagonist. It can relax the smooth muscles in the walls of arteries, allow blood to flow more easily, and lower blood pressure. ...

CAS 55985-32-5 Nicardipine

(CAS: 55985-32-5)

Nicardipine is a calcium channel blocker used to treat high blood pressure and angina.

CAS 116666-63-8 Mibefradil dihydrochloride hydrate

Mibefradil dihydrochloride hydrate
(CAS: 116666-63-8)

The dihydrochloride hydrate salt form of Mibefradil which is a calcium channel blocker with modest selectivity for T-type Ca2+ channels so that it could be used...


(CAS: 111011-63-3)

Efonidipine could be effective in the treatment of cardiovascular disease as a blocker of T-type and L-type calcium channels. It could also present as the hydro...

CAS 116644-53-2 Mibefradil

(CAS: 116644-53-2)

Mibefradil, a calcium channel blocker, has modest selectivity for T-type Ca2+ channels so that could be used in the treatment of sorts of cardiovascular disease...

CAS 248922-46-5 PD0176078

(CAS: 248922-46-5)

PD0176078 is a novel N-type calcium channel blocker.

CAS 72509-76-3 Felodipine

(CAS: 72509-76-3)

Felodipine is a selective L-type Ca2+ channel blocker with IC50 of 0.15 nM. It can lower blood pressure by reducing peripheral vascular resistance via a highly ...

CAS 14663-23-1 Dantrolene Sodium

Dantrolene Sodium
(CAS: 14663-23-1)

Dantrolene Sodium, an inhibitor of calcium channel proteins that markedly suppresses the release of calcium previously sequestered by skeletal, but not cardiac,...

CAS 111011-76-8 Efonidipine hydrochloride monoethanolate

Efonidipine hydrochloride monoethanolate
(CAS: 111011-76-8)

The hydrochloride monoethanolate salt form of Efonidipine which has been launched for hypertension and discontinued for cerebrovascular disorders.

CAS 30484-77-6 Flunarizine Dihydrochloride

Flunarizine Dihydrochloride
(CAS: 30484-77-6)

Flunarizine 2HCl is a dihydrochloride salt form which is a calcium channel blocker with a Ki of 68 nM.

CAS 298-57-7 Cinnarizine

(CAS: 298-57-7)

Cinnarizine, with antiallergic and anti-vasoconstricting activity, is a calcium channel blocker to treat cerebral apoplexy, post-trauma cerebral symptoms, and c...

CAS 180090-15-7 CP-​060

(CAS: 180090-15-7)

CP-​060 is a novel type of Ca(2+) antagonist possessing both Ca(2+) overload inhibition, with antioxidant and cardioprotective activities.

CAS 212778-82-0 Elpetrigine

(CAS: 212778-82-0)

Elpetrigine, also known as GW 273293 and JZP-4, has a blocking effect on calcium channels and potassium channels which has been in clinical bipolar disorders an...

CAS 99254-95-2 McN5691

(CAS: 99254-95-2)

McN5691, an antihypertensive agent, is a voltage-sensitive calcium channel blocker.

CAS 60142-95-2 Gabapentin hydrochloride

Gabapentin hydrochloride
(CAS: 60142-95-2)

Gabapentin HCl is a GABA analogue.Originally it was developed to treat epilepsy, and is currently used to relieve neuropathic pain and restless leg syndrome.

CAS 13636-18-5 Fendiline hydrochloride

Fendiline hydrochloride
(CAS: 13636-18-5)

The hydrochloride salt form of Fendiline, a benzenepropanamine derivative, has been found to be a calcium channel blocker and alpha2-adrenergic receptor antagon...

CAS 167221-71-8 Clevidipine Butyrate

Clevidipine Butyrate
(CAS: 167221-71-8)

Clevidipine Butyrate is a dihydropyridine calcium channel blocker, uses as an agent for the reduction of blood pressure.

CAS 132866-11-6 Lercanidipine Hydrochloride

Lercanidipine Hydrochloride
(CAS: 132866-11-6)

The hydrochloride salt form of Lercanidipine, a dihydropyridine derivative, could be used as an antihypertensive agent through influencing the L-type Ca2+ chann...

CAS 33286-22-5 Diltiazem Hydrochloride

Diltiazem Hydrochloride
(CAS: 33286-22-5)

Diltiazem HCl (Tiazac) is a benzothiazepine derivative with vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions.

CAS 103890-78-4 Lacidipine

(CAS: 103890-78-4)

Lacidipine (Lacipil, Motens) is a L-type calcium channel blocker. Lacidipine (Lacipil, Motens) works by relaxing and opening up the blood vessels.

Reference Reading

1. Polymorphs and solvates of felodipine: analysis of crystal structures and thermodynamic aspects of sublimation and solubility processes
German L. Perlovich,* Svetlana V. Blokhina, Nikolay G. Manin. CrystEngComm, 2012, 14, 8577–8588
Felodipine(Fel) (ethylmethyl-4-(2,3-dichlorophenyl)-1,4-dihy-dro-2,6-dimethyl-3,5-pyridinedicarboxylate) has been chosen as the subject of this study. Being a calcium channel blocker, felodipine is widely used for treating hypertension. The choice of this compound can be explained by the following reasons. Firstly, felodipine has very poor water solubility, so enhancing this property is of great importance. Secondly, the crystal structure information for felodipine polymorphic forms I and II and formamide (FA) crystallosolvate [Fel + FA], described in the literature together with the data of the present investigation, makes it possible to conduct successful comparative analysis of both molecular conformational states in crystals and their packing architectures. The existence of more than two felodipine polymorphic modifications with melting points close to forms I and II has been indicated in several reports including those by Rollinger and Burger and Kercet al.
2. Role of polymer chemistry in influencing crystal growth rates from amorphous felodipine
Umesh S. Kestur and Lynne S. Taylor*. CrystEngComm, 2010, 12, 2390–2397
Thermal analysis was performed using a TA Q2000 DSC equipped with a refrigerated cooling accessory (TA Instruments, New Castle, DE, USA). Nitrogen, 50mL min-1, served as the purge gas and reference and sample pans were matched for weight to within 0.01mg. 3–7mg of the sample were weighed into an aluminium T zero sample pan with a pin hole (TA instruments, New Castle, DE, USA) and sealed. The glass transition temperature (Tg) was determined by heating the sample at 10 oC min-1 and the onset temperature is reported. The thermal history of the samples was erased by heating the sample beyond Tg followed by cooling and reheating, before the actual Tg measurements were made. Melting point (Tm) depression measurements for felodipine alone and felodipine in the presence of polymers were made by heating the samples at 1 oC min-1 to beyond the melting point. Polymers were intimately mixed with pure crystalline felodipine using a cryogenic mill. The offset of melting was taken as the extrapolated offset of the bulk melting endotherm.
3. Polymorphism of felodipine co-crystals with 4,4’-bipyridine
Artem O. Surov, Katarzyna A. Solanko, German L. Perlovich*. CrystEngComm,2014, 16, 6603–6611
In this paper, we focus on the structures and physico-chemical properties of three co-crystals of the API felodipine (Fel)with 4,4’-bipyridine (BP), namely two polymorphs of the co-crystal with a 1 : 1 molar ratio and a co-crystal having a 2 : 1 molar ratio (Fig. 1). This work is a continuation of our previous studies concerning new crystalline forms of felodipine. Felodipine is one of the well-known calcium-channel blocking drugs, and it is it self tetramorphic: forms I and II have been known for a long time, and we have quite recently reported two new polymorphs, forms III and IV. Several solvates are also known in the literature. A solvate with formamide has been reported by Lou et al., and Rollinger and Burger have also described an unstable solvate with acetone, characterized by thermal, IR spectroscopic and powder X-ray diffraction techniques.