|Description||Felbamate (Felbatol) is an anticonvulsant drug used in the treatment of epilepsy.|
L-701,252 is an antagonist at the glycine-NMDA site with IC50 value of 420 nM. It is used as a potent systemic anticonvulsant.
(RS)-(Tetrazol-5-yl)glycine is a highly potent NMDA receptor agonist demonstrating 20 times more active than NMDA.
LY 233536 is a novel competitive N-methyl-D-aspartate (NMDA) receptor antagonist, but few detailed information has been published yet.
PMPA (NMDA antagonist)
PMPA (NMDA antagonist) is a selective competitive antagonist at the NMDA receptor, with Ki= 0.84, 2.74, 3.53 and 4.16 μM at GluN2A, GluN2B, GluN2C and GluN2D su...
(R)-3-Carboxy-4-hydroxyphenylglycine has been found to be an antagonist of NMDA and AMPA/kainate receptor.
DNQX disodium salt
The sodium salt form of DNQX, which is a selective non-NMDA receptor antagonist and could probably be useful in the treatment of Alzheimer's disease.
D-AP5, a more active form of AP5, has been found to be an NMDA antagonist.
DL-AP7, one of the first generation phosphono NMDA antagonists, could be used as an anticonvulsant.
Spermine tetrahydrochloride is a polyamine that binds to and modulates NMDA receptor channel. Spermine also acts as a GluR inhibitor, PLCα inhibitor and PLCδ ac...
Radiprodil is a orally active and selective NMDA NR2B antagonist with a potential therapeutic agent in treatment of neuropathic pain and possibly other chronic ...
RO 25-6981 hydrochloride
RO 25-6981 hydrochloride is a potent and selective antagonist of NMDA glutamate receptors containing the NR2B subunit.
LY 233053 is an NMDA receptor antagonist with IC50 value of 7 nM.
CP 101606 is a potent and selective NR2B antagonist of N-Methyl-D-Aspartate (NMDA) glutamate receptors. It decreases pentylenetetrazol-induced seizures.
5,7-Dichlorokynurenic acid sodium salt
The sodium salt form of 5,7-Dichlorokynurenic acid, which is an effective antagonist at the glycine site of the NMDA receptor.
Rapastinel, a brain penetrable tetrapeptide, could be a partial agonist of NMDA receptor. It was already finished the Phase II trial for acting as an antidepres...
(-)-MK 801 Maleate
MK-801 is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.
Ro 04-5595 hydrochloride is a selective NMDA receptor inhibitor (Ki = 31 nM).
Amantadine is can be used as an antiviral and an antiparkinsonian drug. It is a NMDA receptor antagonist. Amantadine is also a useful building block in organic ...
Ro 25-6981, structurally related to ifenprodil and with no affinity for the known binding sites of non-competitive antagonists such as phencyclidine or MK-801, ...