Fazarabine - CAS 65886-71-7
Catalog number:
65886-71-7
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
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Description:
Fazarabine, also known as Kymarabine,  is an orally-active pyrimidine analogue of an aza-substituted cytidine in which the ribose moiety is replaced by an arabinose sugar. Similar in action to cytarabine, fazarabine is phosphorylated by deoxycytidine kinase to a triphosphate form which competes with thymidine for incorporation into DNA; its incorporation into DNA inhibits DNA synthesis, resulting in tumor cell death and tumor necrosis. The presence of deoxycytidine kinase in a tumor is a determinant of tumor sensitivity to this drug.
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Synonyms:
Fazarabine. Ara-AC; Kymarabine
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CAS 65886-71-7 Fazarabine

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