Faropenem daloxate - CAS 141702-36-5
Catalog number:
141702-36-5
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C17H19NO8S
Molecular Weight:
397.4
COA:
Inquire
Targets:
Antibacterial
Description:
Faropenem daloxate is useful for penem and antibiotics. Faropenem medoxomil has excellent in vitro activity against Streptococcus pneumoniae, Haemophilus influenzae and other key pathogens implicated in acute bacterial rhinosinusitis. Clinical studies have demonstrated that, in the treatment of acute bacterial rhinosinusitis in adults, 7 days of treatment with faropenem medoxomil is as clinically and bacteriologically effective as 10 days of treatment with cefuroxime axetil. One study showed faropenem medoxomil to be superior to cefuroxime axetil. Overall, the safety profile of faropenem medoxomil is similar to that of most comparators.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Synonyms:
Faropenem medoxil
MSDS:
Inquire
1.Faropenem medoxomil: A0026, BAY 56-6854, BAY 566854, faropenem daloxate, SUN 208, SUN A0026.
Drugs R D. 2008;9(2):115-24.
Replidyne is developing faropenem medoxomil, the ester-type prodrug of faropenem, for the treatment of bacterial infections and respiratory tract infections, including acute exacerbations of chronic bronchitis (AECB), acute bacterial sinusitis (ABS) and community-acquired pneumonia (CAP). Faropenem medoxomil is also being developed for the treatment of tonsillitis, pharyngitis and otitis media in children. Faronpenem medoxomil was discovered by scientists at Suntory Institute for Biomedical Research (now Asubio Pharma). The compound has significantly improved oral bioavailability and is dehydropeptidase-I stable. Following absorption, faropenem medoxomil is rapidly hydrolysed to the active drug faropenem. An NDA was filed in the US but was deemed not approvable by the US authorities. Following the termination of the license agreement between Replidyne and Forest Laboratories, Replidyne is now exploring other partnering opportunities for faropenem medoxomil.
2.Gateways to clinical trials. July-August 2008.
Tomillero A, Moral MA. Methods Find Exp Clin Pharmacol. 2008 Jul-Aug;30(6):459-95.
(-)-Epigallocatechin gallate, 501516, 89-12; Abatacept, Adalimumab, Adefovir dipivoxil, AG-701, Agatolimod sodium, Alefacept, Aliskiren fumarate, Apixaban, Atazanavir sulfate, Atrasentan, Axitinib; BI-1744-CL, BIBF-1120, BIBW-2992, Bortezomib; Carboxyamidotriazole, Caspofungin acetate, CBP-501, Cediranib, Ceftobiprole, Certolizumab pegol, Cetuximab, Cholesteryl hydrophobized polysaccharide-Her2 protein complex, CHP-NY-ESO-1, Cypher; Dalbavancin, Dalcetrapib, Daptomycin, Darapladib, Deferasirox, Deforolimus, Denosumab, DNA-HIV-C, Dovitinib, DR-5001, Dronedarone hydrochloride, DT388IL3; E75, EC-17/EC-90, Ecogramostim, Efungumab, Entecavir, EP HIV-1090, EP-2101, Everolimus, Ezetimibe, Ezetimibe/simvastatin; Faropenem daloxate, Fluticasone furoate, Fondaparinux sodium, Fospropofol disodium, Fulvestrant; Golimumab, GSK-089, GW-590735; HO/03/03, hTERT572, hTERT572Y; Iloperidone; Immunoglobulin intravenous (human), Ispinesib mesylate, Istradefylline, Ixabepilone; JR-031, JX-594; KLH; Laropiprant, Lecozotan hydrochloride, Lenalidomide, Lestaurtinib, Linezolid; MGCD-0103, MK-0646, MVA-BN Measles; NI-0401, Niacin/laropiprant, NSC-719239, NYVAC-C; Ospemifene; Paliperidone palmitate, PAN-811, PCV7, Pegfilgrastim, Peginterferon alfa-2a, PEGirinotecan, Perifosine, Pertuzumab, PF-00299804, Picoplatin, Pimavanserin tartrate, Pitavastatin calcium, Pomalidomide, Prasterone, Pratosartan, Prucalopride, PSMA27/pDOM, Pyridoxal phosphate; QS-21, Quercetin; Rebimastat, Rimonabant, Rolofylline, Romidepsin, Rosuvastatin calcium, RTS,S/SBAS2; SCH-530348, SN-29244, Soblidotin, Sodium dichloroacetate, Solifenacin succinate, Sorafenib, Spheramine, SU-6668, Succinobucol; Taranabant, Taxus, Telaprevir, Telavancin hydrochloride, Telbivudine, Tenofovir disoproxil fumarate, Tigecycline, Tiotropium bromide, Tocilizumab, Triphendiol; UC-781, Udenafil, UNIL-025; V-5 Immunitor, Valsartan/amlodipine besylate, Varenicline tartrate, Velafermin, Vernakalant hydrochloride, Vinflunine, Vitespen, Vorinostat, VX-001; Xience V, XRP-0038; Yttrium Y90 Epratuzumab; Z-360, Ziconotide, Ziprasidone hydrochloride, Zotarolimus, Zotarolimus-eluting stent.
3.Human carboxymethylenebutenolidase as a bioactivating hydrolase of olmesartan medoxomil in liver and intestine.
Ishizuka T1, Fujimori I, Kato M, Noji-Sakikawa C, Saito M, Yoshigae Y, Kubota K, Kurihara A, Izumi T, Ikeda T, Okazaki O. J Biol Chem. 2010 Apr 16;285(16):11892-902. doi: 10.1074/jbc.M109.072629. Epub 2010 Feb 19.
Olmesartan medoxomil (OM) is a prodrug type angiotensin II type 1 receptor antagonist widely prescribed as an antihypertensive agent. Herein, we describe the identification and characterization of the OM bioactivating enzyme that hydrolyzes the prodrug and converts to its pharmacologically active metabolite olmesartan in human liver and intestine. The protein was purified from human liver cytosol by successive column chromatography and was identified by mass spectrometry to be a carboxymethylenebutenolidase (CMBL) homolog. Human CMBL, whose endogenous function has still not been reported, is a human homolog of Pseudomonas dienelactone hydrolase involved in the bacterial halocatechol degradation pathway. The ubiquitous expression of human CMBL gene transcript in various tissues was observed. The recombinant human CMBL expressed in mammalian cells was clearly shown to activate OM. By comparing the enzyme kinetics and chemical inhibition properties between the recombinant protein and human tissue preparations, CMBL was demonstrated to be the primary OM bioactivating enzyme in the liver and intestine.
4.Juvenile toxicity study of faropenem medoxomil in beagle puppies.
Faqi AS1, Lanphear C, Gill S, Colagiovanni DB. Reprod Toxicol. 2010 Dec;30(4):619-24. doi: 10.1016/j.reprotox.2010.07.010. Epub 2010 Aug 11.
We determined the toxicity of faropenem medoxomil (FPM) in neonatal/juvenile dogs following 28 days of administration. The puppies received vehicle or FPM beginning on Postnatal Day (PND) 22 at respective dose levels of 0, 100, 300, 600, or 1400 mg/kg-d (four daily doses (QID) of 25, 75, 150, or 350 mg/kg/dose), respectively, at a dose volume of 5 mL/kg/dose. Body weight, food consumption, clinical observation, clinical pathology, urine analysis and TK were evaluated. Body weight in males and kidney findings at 1400 mg/kg-d were considered adverse. Comparison of Day 27 TK values with Day 1 parameters showed a change in FPM pharmacokinetic behavior over time with an apparent increase in the rate of clearance characterized by a decrease in AUC(0-6) and T(max) values on Day 27 with little to no change in C(max) values. Based on these results, the No Observed Adverse Effect Level was 600 mg/kg-d.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Antibacterial Products


ABT-255
(CAS: 186293-38-9)

ABT-255, a novel 2-pyridone antibacterial agent, is an analog of ABT-719 with improvements in the therapeutic margin against common gram-positive and -negative ...

CAS 56-75-7 Chloramphenicol

Chloramphenicol
(CAS: 56-75-7)

Chloramphenicol is an antibiotic useful for the treatment of a number of bacterial infections.

CHIR-090
(CAS: 728865-23-4)

CHIR-090 is a very potent and tight-binding inhibitor of LpxC, which is a zinc-dependent amidase and present in almost all Gram-negative bacteria, and is a prom...

CAS 18472-51-0 Chlorhexidine digluconate

Chlorhexidine digluconate
(CAS: 18472-51-0)

Chlorhexidine has been used to study how essential oils improve skin antisepsis when combined with chlorhexidine digluconate and is used for skin permeation stu...

CAS 137330-13-3 Tilmicosin phosphate

Tilmicosin phosphate
(CAS: 137330-13-3)

Tilmicosin phosphate, an antibiotic, has been commonly used as a veterinary drug against ovine respiratory disease for bovine and ovine.

CAS 1264-72-8 Colistin Sulfate

Colistin Sulfate
(CAS: 1264-72-8)

Colistin is a cyclic cationic decapeptide linked to a fatty acid side chain, it belongs to a group of similarly structured bacterial antimicrobial peptides.

CAS 1405-37-4 Capreomycin Sulfate

Capreomycin Sulfate
(CAS: 1405-37-4)

Capreomycin Sulfate is a cyclic peptide antibiotic and thought to inhibit protein synthesis by binding to the 70S ribosomal unit.

N-Acetyl-Calicheamicin
(CAS: 108212-76-6)

N-Acetyl-Calicheamicin, a derivative of Calicheamicin, is a member of enediyne antitumor antibiotics that could be a potential cytotoxic DNA-binding agent.

CAS 121123-17-9 Cefprozil monohydrate

Cefprozil monohydrate
(CAS: 121123-17-9)

Cefprozil hydrate (Cefzil) is a second-generation cephalosporin type antibiotic. Cefprozil hydrate (Cefzil) can be used to treat bronchitis, ear infections, ski...

CAS 3697-42-5 chlorhexidine dihydrochloride

chlorhexidine dihydrochloride
(CAS: 3697-42-5)

Chlorhexidine hydrochloride is an antiseptic effective against a wide variety of gram-negative and gram-positive organisms.

CAS 88-04-0 4-Chloro-3,5-dimethylphenol

4-Chloro-3,5-dimethylphenol
(CAS: 88-04-0)

4-Chloro-3,5-dimethylphenol is a chemical compound which has antimicrobial effect due to disruption of cell membrane potentials. lt is an antiseptic and germici...

CAS 140-40-9 Nithiamide

Nithiamide
(CAS: 140-40-9)

Nithiamide is efficient in preventing and treating swine dysentery in experimentally inoculated pigs.

Oritavancin diphosphate
(CAS: 192564-14-0)

Oritavancin, also known as LY333328, is a novel semisynthetic glycopeptide antibiotics.Oritavancin possesses potent and rapid bactericidal activity in vitro aga...

CAS 37693-01-9 Clofoctol

Clofoctol
(CAS: 37693-01-9)

Clofoctol is a bacteriostatic antibiotic used to against gram-positive bacteria.

CAS 16773-42-5 Ornidazole

Ornidazole
(CAS: 16773-42-5)

Ornidazole is a 5-nitroimidazole derivative with antiprotozoal and antibacterial properties against anaerobic bacteria.

CAS 4800-94-6 Carbenicillin disodium

Carbenicillin disodium
(CAS: 4800-94-6)

Carbenicillin is a semi-synthetic penicillin antibiotic which interferes with cell wall synthesis of gram-negative bacteria while displaying low toxicity. The c...

CAS 5321-32-4 Hetacillin potassium

Hetacillin potassium
(CAS: 5321-32-4)

Hetacillin potassium is a penicillin beta-lactam antibiotic reatment for use against a wide range of common Gram-positive and Gram-negative bacteria.

CAS 14222-60-7 Prothionamide

Prothionamide
(CAS: 14222-60-7)

An anti-tuberculosis agent. It has also been used to treat Leprosy. Antibacterial (tuberculostatic).

CAS 116-45-0 Sulfabrom

Sulfabrom
(CAS: 116-45-0)

Sulfabrom, a long-acting derivative of sulfamezathine, is used for the treatment of coccidiosis and various bacterial infections in the poultry, swine and cattl...

CAS 144-83-2 Sulfapyridine

Sulfapyridine
(CAS: 144-83-2)

Sulfapyridine is a sulfonamide antibacterial.

Chemical Structure

CAS 141702-36-5 Faropenem daloxate

Quick Inquiry

Verification code

Featured Items