Facinicline - CAS 677306-35-3
Catalog number:
677306-35-3
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C15H18N4O
Molecular Weight:
270.34
COA:
Inquire
Targets:
nAChR
Description:
Facinicline is a partial agonist of the nicotinic alpha-7 (α7) receptor. It is used for the oral treatment of Alzheimer's. It was being co-developed by Roche and was in clinic phase 2 trials with no progress.
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Purity:
98%
Appearance:
Solid powder
Synonyms:
RG-3487;MEM-3454;RO-5313534;RG3487;MEM3454;RO5313534;(S)-N-(quinuclidin-3-yl)-1H-indazole-3-carboxamide;N-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-1H-indazole-3-carboxamide
Solubility:
Soluble in DMSO, not in water
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
Facinicline is used for the oral treatment of Alzheimer's.
Quality Standard:
In-house standard
Quantity:
Milligrams-Grams
Boiling Point:
558.8±30.0 °C | Condition: Press: 760 Torr
Density:
1.33±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
TXCYUSKWBHUVEP-CYBMUJFWSA-N
InChI:
InChI=1S/C15H18N4O/c20-15(14-11-3-1-2-4-12(11)17-18-14)16-13-9-19-7-5-10(13)6-8-19/h1-4,10,13H,5-9H2,(H,16,20)(H,17,18)/t13-/m1/s1
Canonical SMILES:
C1CN2CCC1C(C2)NC(=O)C3=NNC4=CC=CC=C43
Current Developer:
Facinicline was being co-developed by Roche and was in clinic phase 2 trials with no progress.
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