EVP-0015962 - CAS 1447811-26-8
Catalog number:
1447811-26-8
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C22H19ClF6O3
Molecular Weight:
480.83
COA:
Inquire
Targets:
Amyloid Precursor Protein Secretase
Description:
EVP-0015962 is a selective Amyloid precursor protein secretase modulator under the development of FORUM Pharmaceuticals. Chronic treatment with EVP-0015962 can lower the production of Aβ42, attenuate memory deficits, and reduce Aβ plaque formation and inflammation in Tg2576 transgenic animals. EVP-0015962 shows a therapeutic alternative for disease modification in Alzheimer's disease. In Jun 2016, Phase-II for Alzheimer's disease in USA was discontinued.
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Purity:
98%
Appearance:
Powder
Synonyms:
SCHEMBL3660255; ZSERTYLZGRJLOO-UHFFFAOYSA-N; 2-(5-chloro-6-(2,2,2-trifluoroethoxy)-4'-(trifluoromethyl)biphenyl-3-yl)-3-cyclobutylpropanoic acid
Solubility:
Soluble in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
Alzheimer's disease
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
InChIKey:
ZSERTYLZGRJLOO-UHFFFAOYSA-N
InChI:
InChI=1S/C22H19ClF6O3/c23-18-10-14(17(20(30)31)8-12-2-1-3-12)9-16(19(18)32-11-21(24,25)26)13-4-6-15(7-5-13)22(27,28)29/h4-7,9-10,12,17H,1-3,8,11H2,(H,30,31)
Canonical SMILES:
C1CC(C1)CC(C2=CC(=C(C(=C2)C3=CC=C(C=C3)C(F)(F)F)OCC(F)(F)F)Cl)C(=O)O
Current Developer:
FORUM Pharmaceuticals
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EVP-0015962
(CAS: 1447811-26-8)

EVP-0015962 is a selective Amyloid precursor protein secretase modulator under the development of FORUM Pharmaceuticals. Chronic treatment with EVP-0015962 can ...

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