Evogliptin - CAS 1222102-29-5
Catalog number: 1222102-29-5
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C19H26F3N3O3
Molecular Weight:
401.43
COA:
Inquire
Targets:
DPP4
Description:
This active molecular is a selective dipeptidyl peptidase 4 (DPP4) inhibitor under the development of Dong-A. Evogliptin improves insulin resistance and delays the onset of diabetes. Evogliptin monotherapy improved HbA1c, fasting plasma glucose level, OGTT results and β-cell function. In Sep 1st 2016, preclinical trials in Type-2 diabetes mellitus (Combination therapy) in Russia was on-going. In Sep 12th 2016, Phase-I clinical trials in non-alcoholic steatohepatitis (Combination therapy) in USA was on-going.
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Purity:
98%
Appearance:
Powder
Synonyms:
(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-[(2-methylpropan-2-yl)oxymethyl]piperazin-2-one;CHEMBL1779710; UNII-09118300L7; DA-1229; 1222102-29-5; Evogliptin [INN];1246960-27-9 (HCl)
Solubility:
Soluble in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
Type-2 diabetes mellitus
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
InChIKey:
LCDDAGSJHKEABN-MLGOLLRUSA-N
InChI:
InChI=1S/C19H26F3N3O3/c1-19(2,3)28-10-16-18(27)24-4-5-25(16)17(26)8-12(23)6-11-7-14(21)15(22)9-13(11)20/h7,9,12,16H,4-6,8,10,23H2,1-3H3,(H,24,27)/t12-,16-/m1/s1
Canonical SMILES:
CC(C)(C)OCC1C(=O)NCCN1C(=O)CC(CC2=CC(=C(C=C2F)F)F)N
Current Developer:
Dong-A ST; GEROPHARM; Luye Pharma Group; Tobira Therapeutics
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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