|source\Analogue Sets||Streptomyces | Tacrolimus Analogue Set|
|Description||Everolimus is an inhibitor of mammalian target of rapamycin (mTOR) with an immunosuppressive activity which is comparable to that of rapamycin. It inhibits cytokine-mediated lymphocyte proliferation. Everolimus can be used as an immunosuppressant in the treatment of renal cell cancer and other cancers.|
|B1335-476235||100 mg||$198||In stock|
|Brife Description||inhibitor of mTOR, immunosuppressant|
|Purity||>95% by HPLC|
|Appearance||Off-White to Pale Yellow Solid|
|Synonyms||Afinitor; Certican; Zortress; RAD001; SDZ-RAD; 40-O-(2-Hydroxyethyl)rapamycin; 42-O-(2-Hydroxy)ethyl Rapamycin|
|Solubility||Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.|
|Shelf Life||2 years|
|Melting Point||107-113 °C|
A methylated diketopiperazine formed by the condensation of phenylalanine; produced by a number of species in the streptomyces genus; exhibits little activity i...
A complex family of macrocyclic lactones containing a highly characteristic spiroketal group; the dominant member of a group of analogues containing a 25-ethyl ...
A member of a potent family of macrocyclic lactones; broadly active against bacteria, fungi, insects, nematodes and cestodes; a potential agent for treating ost...
A cyclic depsipeptide metabolite; has broad activity against bacteria, fungi and viruses; an antitumour agent by bifunctional intercalation of nucleic acids; an...
Everolimus is an inhibitor of mammalian target of rapamycin (mTOR) with an immunosuppressive activity which is comparable to that of rapamycin. It inhibits cyto...
The major analogue of a family of pyridyl antibiotics isolated from selected streptomyces species; a specific, potent inhibitor of NADH-ubiquinone oxidoreductas...
A macrocyclic lactone closely related to tacrolimus and rapamycin; isolated from several species of streptomyces; exhibits limited, potent antifungal activity; ...
A triene macrolide; a metabolite of streptomyces hygroscopicus; displayed potent and selective antifungal activity, notably against candida albicans; inhibits t...
A metabolite produced by several species of penicillium; a strong inhibitor of tnfα-induced replication of HIV
A β-lactam antibiotic produced by several species of streptomyces; a weak antibiotic, but is a potent inhibitor of β-lactamases; shows potent synergistic activi...
A semisynthetic macrocyclic lactone prepared from rapamycin by selective alkylation of the 42-hydroxy group with a dimethylphosphinate moiety;s binds to recepto...
An indolocarbazole isolated from a high staurosporine-producing streptomyces culture; inhibits protein kinase C (PKC) and cyclin-dependant kinase 2 (CDK2), resu...
A nucleoside antibiotic isolated from streptomyces alboniger; an anti-trypansomal agent with antibiotic activity; non-selective, inhibiting RNA by blocking ribo...
The second discovered tetracycline antibiotic
A distinctive yellow pigment produced by some species of pseudomonas and streptomyces; one of two toxins produced when a fermented coconut drink, tempe bonkrek;...
A macrocyclic antibiotic with potent and selective antibacterial activity; a potent inhibitor of the oncogenic transcription factor, foxm1; inhibits foxm1-induc...
A potent inhibitor of IL2 production in a targeted search for novel immunosuppressants; acts by blocking T cell proliferation in vitro by inhibiting the generat...
A polyaromatic heterocycle containing a rare N-aminoamide; isolated from a streptomyces species; exhibits a broad biological profile with antibiotic, antifungal...
The first of the aureolic acid class of antitumour antibiotics; isolated from streptomyces; inhibits transcription and protein synthesis by non-covalent binding...
One of a family of depsipeptide antibiotics co-produced with ostreogrycin A; acts a synergist, binding to the conformational change of the peptidyl transferase ...