Everolimus - CAS 159351-69-6
Catalog number: 159351-69-6
Molecular Formula:
C53H83NO14
Molecular Weight:
958.24
COA:
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Description:
Everolimus is a derivative of Rapamycin. Everolimus is an inhibitor of mammalian target of rapamycin (mTOR) with an immunosuppressive activity which is comparable to that of rapamycin. It inhibits cytokine-mediated lymphocyte proliferation. Everolimus can be used as an immunosuppressant in the treatment of renal cell cancer and other cancers.
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Brife Description:
inhibitor of mTOR, immunosuppressant
Purity:
> 95%
Appearance:
Off-White to Pale Yellow Solid
Synonyms:
Afinitor; Certican; Zortress; RAD001; SDZ-RAD; 40-O-(2-Hydroxyethyl)rapamycin; 42-O-(2-Hydroxy)ethyl Rapamycin
Solubility:
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
MSDS:
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Application:
immunosuppressant
Shelf Life:
2 years
Quantity:
Milligrams-Grams
Melting Point:
107-113 °C
InChIKey:
HKVAMNSJSFKALM-GKUWKFKPSA-N
InChI:
InChI=1S/C53H83NO14/c1-32-16-12-11-13-17-33(2)44(63-8)30-40-21-19-38(7)53(62,68-40)50(59)51(60)54-23-15-14-18-41(54)52(61)67-45(35(4)28-39-20-22-43(66-25-24-55)46(29-39)64-9)31-42(56)34(3)27-37(6)48(58)49(65-10)47(57)36(5)26-32/h11-13,16-17,27,32,34-36,38-41,43-46,48-49,55,58,62H,14-15,18-26,28-31H2,1-10H3/b13-11+,16-12+,33-17+,37-27+/t32-,34-,35-,36-,38-,39+,40+,41+,43-,44+,45+,46-,48-,49+,53-/m1/s1
Canonical SMILES:
CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)OCCO)C)C)O)OC)C)C)C)OC
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CAS 159351-69-6 Everolimus

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