Etybenzatropine - CAS 524-83-4
Catalog number:
524-83-4
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C22H27NO
Molecular Weight:
321.46
COA:
Inquire
Targets:
Dopamine Receptor
Description:
Etybenzatropine is an anticholinergic/antihistamine. It is used as an antiparkinsonian agent. It may act as a dopamine reuptake inhibitor.
Publictions citing BOC Sciences Products
  • >> More
Purity:
95%
Appearance:
Solid powder
Synonyms:
Ponalide;UK-738;VK-738;(1R,5S)-3-benzhydryloxy-8-ethyl-8-azabicyclo[3.2.1]octane;3-alpha-(Diphenylmethoxy)-8-ethyl-1alphaH,5alphaH-nortropane;3-(Diphenylmethoxy)-8-ethylnortropane;N-Ethylnortropine benzhydryl ether;Nortropane, 3-(diphenylmethoxy)-8-ethyl-
Solubility:
Soluble in DMSO, not in water
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
Etybenzatropine is used as an antiparkinsonian agent.
Quality Standard:
In-house standard
Quantity:
Milligrams-Grams
Boiling Point:
422.8±45.0 °C | Condition: Press: 760 Torr
Density:
1.10±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
PHTMLLGDZBZXMW-WCRBZPEASA-N
InChI:
InChI=1S/C22H27NO/c1-2-23-19-13-14-20(23)16-21(15-19)24-22(17-9-5-3-6-10-17)18-11-7-4-8-12-18/h3-12,19-22H,2,13-16H2,1H3/t19-,20+,21?
Canonical SMILES:
CCN1C2CCC1CC(C2)OC(C3=CC=CC=C3)C4=CC=CC=C4
1.[CORRECTION BY ETYBENZATROPINE OF EXTRAPYRAMIDAL SYMPTOMS DUE TO NEUROLEPTICS].
BORENSTEIN P, BLES G. Presse Med. 1964 May 30;72:1595-6.
2.Effects of etybenzatropine and diazepam on levodopa-induced diphasic dyskinesias in Parkinson's disease.
Pourcher E1, Bonnet AM, Kefalos J, Dubois B, Agid Y. Mov Disord. 1989;4(3):195-201.
Levodopa-induced onset and end-of-dose dyskinesia are rare but disabling disorders. Although they can be attenuated by increasing and dividing the daily dose of levodopa, this does not constitute a therapeutic approach. In this pilot study, etybenzatropine, an anticholinergic drug, and diazepam, a selective benzodiazepine, were administered in addition to a single dose of levodopa in nine patients with Parkinson's disease. Both drugs tended to decrease the severity and the duration of onset and end-of-dose dyskinesia and to increase the duration of action of levodopa on parkinsonian symptoms.
3.Beneficial effects of dantrolene in the treatment of neuroleptic malignant syndrome: a report of two cases.
Goulon M, de Rohan-Chabot P, Elkharrat D, Gajdos P, Bismuth C, Conso F. Neurology. 1983 Apr;33(4):516-8.
Two schizophrenic patients developed muscular rigidity, stupor, and hyperpyrexia consistent with neuroleptic malignant syndrome, 8 to 10 days after starting haloperidol therapy. Muscle rigidity was not affected by etybenzatropine or diazepam, but dantrolene, a direct-acting skeletal muscle relaxant, provided muscle relaxation with a concomitant decrease of fever and serum creatine kinase. Neuroleptic malignant syndrome and malignant hyperthermia are clinically similar, and dantrolene is effective in both; suggesting a muscular origin of fever in these two diseases.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Dopamine Receptor Products


CAS 69-09-0 Chlorpromazine HCl

Chlorpromazine HCl
(CAS: 69-09-0)

Chlorpromazine HCl is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 μM for inward-rectifying K+ currents and time-independent outward curre...

CAS 1098-60-8 Triflupromazine Hydrochloride

Triflupromazine Hydrochloride
(CAS: 1098-60-8)

The hydrochloride salt form of Triflupromazine, an analogue of Chlorpromazine, is effective as nntipsychotic drug and antemetic agent.

Ecopipam
(CAS: 112108-01-7)

Ecopipam, a synthetic benzazepine derivative drug, acts as a selective dopamine D1/D5 receptor antagonist with little affinity for either dopamine D2-like or 5-...

Amitifadine hydrochloride
(CAS: 410074-74-7)

A Serotonin-Preferring Triple Reuptake Inhibitor for the Treatment of Major Depression, with the IC50 values for serotonin, norepinephrine and dopamine reuptake...

JPC-211
(CAS: 82668-33-5)

JPC-211 is a selective dopamine D3 receptor agonist.

CAS 57645-91-7 Clebopride Malate

Clebopride Malate
(CAS: 57645-91-7)

Clebopride is a substituted benzamide as a dopamine antagonist used to treat functional gastrointestinal disorders.

CAS 32795-47-4 Nomifensine maleate

Nomifensine maleate
(CAS: 32795-47-4)

Nomifensine maleate is maleate salt form of Nomifensine. Nomifensine, also called as Hoe 984 or Linamiphen, as a norepinephrine-dopamine reuptake inhibitor it i...

CAS 62-31-7 Dopamine HCl

Dopamine HCl
(CAS: 62-31-7)

Dopamine HCl is a catecholamine neurotransmitter present in a wide variety of animals, and a dopamine D1-5 receptors agonist.

Aplindore Fumarate
(CAS: 189681-71-8)

Aplindore Fumarate is a partial agonist selective for the dopamine receptor D2 used in the therapeutic treatment of Parkinson Disease and restless legs syndrome...

CAS 19262-68-1 Dexmethylphenidate HCl

Dexmethylphenidate HCl
(CAS: 19262-68-1)

Dexmethylphenidate HCl, a synthetic sympathomimetic controlled amine with CNS stimulating properties used most commonly in the treatment of attention-deficit di...

Nolomirole hydrochloride
(CAS: 138531-51-8)

Nolomirole is a Alpha 2 adrenergic receptor and Dopamine D2 receptor agonist. Nolomirole can attenuate the heart failure signs in the monocrotaline-induced cong...

Vanoxerine
(CAS: 67469-69-9)

Vanoxerin is a dopamine uptake inhibitor. It is potentially used for the treatment of atrial fibrillation.

CAS 146-56-5 Fluphenazine DiHCl

Fluphenazine DiHCl
(CAS: 146-56-5)

Fluphenazine DiHCl is the dihydrochloride salt preparation of Fluphenazine. It has been used to deliver Fluphenazine to biological systems in studies probing th...

CAS 41372-20-7 (R)-Apomorphine Hydrochloride Hemihydrate

(R)-Apomorphine Hydrochloride Hemihydrat
(CAS: 41372-20-7)

(R)-Apomorphine is a non-selective dopamine agonist which activates both D1-likeand D2-like receptors, with some preference for the latter subtypes.

CAS 57202-76-3 6-Methyl Pergolide

6-Methyl Pergolide
(CAS: 57202-76-3)

6-Methyl Pergolide is a dopamine agonist. It is also a potent antagonist of 5-HT2A and 5-HT2B receptors on porcine cardiac valves. It increases serum corticoste...

CAS 53-60-1 Promazine Hydrochloride

Promazine Hydrochloride
(CAS: 53-60-1)

Promazine Hydrochloride is a phenothiazine used in short-term treatment of disturbed behavior and as an antiemetic.

CAS 19875-60-6 Lisuride maleate

Lisuride maleate
(CAS: 19875-60-6)

Lisuride maleate, an ergot derivative, is a nonselective dopamine receptor agonist with high affinity for D2, D3 and D4 receptors along with 5-HT1A. As an anti-...

CAS 32672-69-8 Mesoridazine besylate

Mesoridazine besylate
(CAS: 32672-69-8)

Mesoridazine besylate, a phenothiazine dopamine receptor anatagonist, has been described to demonstrate inhibition for D2DR and D4DR. High affinity for the clon...

CAS 104632-28-2 Dexpramipexole

Dexpramipexole
(CAS: 104632-28-2)

Dexpramipexole, also known as R-(+)-Pramipexole, is one of the impurities of pramipexole(USP D). It coule be used as a negative control in the research of dopam...

CAS 91374-20-8 Ropinirole HCl

Ropinirole HCl
(CAS: 91374-20-8)

Ropinirole a selective D-2 agonist with Ki of 29 nM.

Chemical Structure

CAS 524-83-4 Etybenzatropine

Quick Inquiry

Verification code

Featured Items