Etybenzatropine - CAS 524-83-4
Catalog number:
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Dopamine Receptor
Etybenzatropine is an anticholinergic/antihistamine. It is used as an antiparkinsonian agent. It may act as a dopamine reuptake inhibitor.
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Solid powder
Ponalide;UK-738;VK-738;(1R,5S)-3-benzhydryloxy-8-ethyl-8-azabicyclo[3.2.1]octane;3-alpha-(Diphenylmethoxy)-8-ethyl-1alphaH,5alphaH-nortropane;3-(Diphenylmethoxy)-8-ethylnortropane;N-Ethylnortropine benzhydryl ether;Nortropane, 3-(diphenylmethoxy)-8-ethyl-
Soluble in DMSO, not in water
-20°C Freezer
Etybenzatropine is used as an antiparkinsonian agent.
Quality Standard:
In-house standard
Boiling Point:
422.8±45.0 °C | Condition: Press: 760 Torr
1.10±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
Canonical SMILES:
BORENSTEIN P, BLES G. Presse Med. 1964 May 30;72:1595-6.
2.Effects of etybenzatropine and diazepam on levodopa-induced diphasic dyskinesias in Parkinson's disease.
Pourcher E1, Bonnet AM, Kefalos J, Dubois B, Agid Y. Mov Disord. 1989;4(3):195-201.
Levodopa-induced onset and end-of-dose dyskinesia are rare but disabling disorders. Although they can be attenuated by increasing and dividing the daily dose of levodopa, this does not constitute a therapeutic approach. In this pilot study, etybenzatropine, an anticholinergic drug, and diazepam, a selective benzodiazepine, were administered in addition to a single dose of levodopa in nine patients with Parkinson's disease. Both drugs tended to decrease the severity and the duration of onset and end-of-dose dyskinesia and to increase the duration of action of levodopa on parkinsonian symptoms.
3.Beneficial effects of dantrolene in the treatment of neuroleptic malignant syndrome: a report of two cases.
Goulon M, de Rohan-Chabot P, Elkharrat D, Gajdos P, Bismuth C, Conso F. Neurology. 1983 Apr;33(4):516-8.
Two schizophrenic patients developed muscular rigidity, stupor, and hyperpyrexia consistent with neuroleptic malignant syndrome, 8 to 10 days after starting haloperidol therapy. Muscle rigidity was not affected by etybenzatropine or diazepam, but dantrolene, a direct-acting skeletal muscle relaxant, provided muscle relaxation with a concomitant decrease of fever and serum creatine kinase. Neuroleptic malignant syndrome and malignant hyperthermia are clinically similar, and dantrolene is effective in both; suggesting a muscular origin of fever in these two diseases.
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CAS 524-83-4 Etybenzatropine

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