Etybenzatropine - CAS 524-83-4
Catalog number: 524-83-4
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C22H27NO
Molecular Weight:
321.46
COA:
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Targets:
Dopamine Receptor
Description:
Etybenzatropine is an anticholinergic/antihistamine. It is used as an antiparkinsonian agent. It may act as a dopamine reuptake inhibitor.
Purity:
95%
Appearance:
Solid powder
Synonyms:
Ponalide;UK-738; UK738; UK 738; VK-738; VK 738; VK738; (1R,5S)-3-benzhydryloxy-8-ethyl-8-azabicyclo[3.2.1]octane;3-alpha-(Diphenylmethoxy)-8-ethyl-1alphaH,5alphaH-nortropane;3-(Diphenylmethoxy)-8-ethylnortropane;N-Ethylnortropine benzhydryl ether;Nortropane, 3-(diphenylmethoxy)-8-ethyl-
Solubility:
Soluble in DMSO, not in water
Storage:
-20°C Freezer
MSDS:
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Application:
Etybenzatropine is used as an antiparkinsonian agent.
Quality Standard:
In-house standard
Quantity:
Milligrams-Grams
Boiling Point:
422.8±45.0 °C | Condition: Press: 760 Torr
Density:
1.10±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
PHTMLLGDZBZXMW-WCRBZPEASA-N
InChI:
InChI=1S/C22H27NO/c1-2-23-19-13-14-20(23)16-21(15-19)24-22(17-9-5-3-6-10-17)18-11-7-4-8-12-18/h3-12,19-22H,2,13-16H2,1H3/t19-,20+,21?
Canonical SMILES:
CCN1C2CCC1CC(C2)OC(C3=CC=CC=C3)C4=CC=CC=C4
1.[CORRECTION BY ETYBENZATROPINE OF EXTRAPYRAMIDAL SYMPTOMS DUE TO NEUROLEPTICS].
BORENSTEIN P, BLES G. Presse Med. 1964 May 30;72:1595-6.
2.Effects of etybenzatropine and diazepam on levodopa-induced diphasic dyskinesias in Parkinson's disease.
Pourcher E1, Bonnet AM, Kefalos J, Dubois B, Agid Y. Mov Disord. 1989;4(3):195-201.
Levodopa-induced onset and end-of-dose dyskinesia are rare but disabling disorders. Although they can be attenuated by increasing and dividing the daily dose of levodopa, this does not constitute a therapeutic approach. In this pilot study, etybenzatropine, an anticholinergic drug, and diazepam, a selective benzodiazepine, were administered in addition to a single dose of levodopa in nine patients with Parkinson's disease. Both drugs tended to decrease the severity and the duration of onset and end-of-dose dyskinesia and to increase the duration of action of levodopa on parkinsonian symptoms.
3.Beneficial effects of dantrolene in the treatment of neuroleptic malignant syndrome: a report of two cases.
Goulon M, de Rohan-Chabot P, Elkharrat D, Gajdos P, Bismuth C, Conso F. Neurology. 1983 Apr;33(4):516-8.
Two schizophrenic patients developed muscular rigidity, stupor, and hyperpyrexia consistent with neuroleptic malignant syndrome, 8 to 10 days after starting haloperidol therapy. Muscle rigidity was not affected by etybenzatropine or diazepam, but dantrolene, a direct-acting skeletal muscle relaxant, provided muscle relaxation with a concomitant decrease of fever and serum creatine kinase. Neuroleptic malignant syndrome and malignant hyperthermia are clinically similar, and dantrolene is effective in both; suggesting a muscular origin of fever in these two diseases.
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