Etretinate - CAS 54350-48-0
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Not Intended for Therapeutic Use. For research use only.
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Etretinate is a second-generation retinoid to treat severe psoriasis. It has been replaced by acitretin, a safer metabolite of etretinate.
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Tegison; Tigason; Ro 10-9359
1.A patient with localized scleroderma successfully treated with etretinate.
Shima T1, Yamamoto Y1, Ikeda T1, Furukawa F1. Case Rep Dermatol. 2014 Sep 3;6(3):200-6. doi: 10.1159/000367707. eCollection 2014.
There are several treatment methods for localized scleroderma, but treatment is difficult when the lesion is widely distributed. We encountered a case who was treated successfully with etretinate, a vitamin A derivative. The usefulness of this agent is discussed.
2.A Case of Old Age-Onset Generalized Pustular Psoriasis with a Deficiency of IL-36RN (DITRA) Treated by Granulocyte and Monocyte Apheresis.
Tominaga C1, Yamamoto M1, Imai Y1, Yamanishi K1. Case Rep Dermatol. 2015 Feb 21;7(1):29-35. doi: 10.1159/000380876.
A 78-year-old woman who had been suffering from psoriasis vulgaris for 31 years was admitted to hospital because of her erythroderma. A toxic eruption was suspected and she was treated with prednisolone 30 mg daily. However, it was ineffective and, suspecting psoriatic erythroderma, cyclosporine 150 mg daily was administered with tapering of the prednisolone. Two weeks after a dose reduction of cyclosporine to 100 mg/day, erythroderma with widespread generalized pustules and fever developed. Histology of a biopsy revealed inflammatory infiltrates in the skin with a spongiform pustule of Kogoj, which was consistent with generalized pustular psoriasis (GPP). Her pustules improved with additional etretinate 20 mg/day, but the erythroderma persisted and she consulted us. Three sessions of granulocyte and monocyte apheresis once weekly were effective for her condition and decreased her serum levels of IL-6 and IL-8. She had homozygous mutations of c.
3.Infantile generalized pustular psoriasis: successful disease control with intermittent etretinate.
Namba C1, Murakami M, Hanakawa Y, Tohyama M, Shirakata Y, Tauchi H, Sayama K. J Dermatol. 2014 May;41(5):403-6. doi: 10.1111/1346-8138.12481.
Infantile generalized pustular psoriasis is a rare form of psoriasis and the best treatment is controversial. We experienced a 2-year-old female with erythema on her neck and axilla starting at 3 months of age. She presented with recurrent annular and geographic scaly erythema with a few pustules on the neck, precordium and axilla, but no fever. The histopathology revealed subcorneal neutrophilic infiltration and microabscesses without Kogoj's spongiform pustules. The initial diagnosis was subcorneal pustular dermatosis. However, she developed widespread geographic erythema and numerous pustules over her entire body with a fever when she got a cold. A second skin biopsy revealed monolocular pustules and Kogoj's spongiform pustules in the subcorneal layer. Etretinate was administrated after a diagnosis of pustular psoriasis was made and her condition improved gradually. The choice of treatment depends on patient age, general condition and the disease severity.
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CAS 54350-48-0 Etretinate

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