Etoposide - CAS 33419-42-0
Catalog number: 33419-42-0
Category: Inhibitor
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Molecular Formula:
C29H32O13
Molecular Weight:
588.56
COA:
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Targets:
Topoisomerase
Description:
Etoposide is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity.
Purity:
>98%
Synonyms:
VP-16, VP-16213; VP 16, VP 16213; VP16, VP16213
MSDS:
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InChIKey:
VJJPUSNTGOMMGY-MRVIYFEKSA-N
InChI:
InChI=1S/C29H32O13/c1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)19(5-12)35-3/h4-7,11,15,20-22,24-27,29-32H,8-10H2,1-3H3/t11-,15+,20-,21-,22+,24-,25-,26-,27-,29+/m1/s1
Canonical SMILES:
CC1OCC2C(O1)C(C(C(O2)OC3C4COC(=O)C4C(C5=CC6=C(C=C35)OCO6)C7=CC(=C(C(=C7)OC)O)OC)O)O
1.Bortezomib and etoposide combinations exert synergistic effects on the human prostate cancer cell line PC-3.
Aras B1, Yerlikaya A2. Oncol Lett. 2016 May;11(5):3179-3184. Epub 2016 Mar 16.
Novel treatment modalities are urgently required for androgen-independent prostate cancer. In order to develop an alternative treatment for prostate cancer, the cytotoxic effects of the 26S proteasome inhibitor bortezomib, either alone or in combination with the two commonly used chemotherapeutic agents irinotecan and etoposide, on the human prostate cancer cell line PC-3 were evaluated in the present study. The PC-3 cell line was maintained in Dulbecco's modified Eagle's medium with 10% fetal bovine serum and treated with various doses of bortezomib, irinotecan, etoposide or their combinations. The growth inhibitory and cytotoxic effects were determined by water-soluble tetrazolium (WST)-1 assay, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay or iCELLigence system. The combination index values were determined by the Chou-Talalay method. The half maximal inhibitory concentration (IC50) value of bortezomib on the PC-3 cell line was determined to be 53.
2.Ifosfamide and Etoposide Chemotherapy in the Treatment of Recurrent/Refractory Rhabdomyosarcoma in Adults.
Sasada S1, Kodaira M1, Shimoi T1, Shimomura A1, Yunokawa M1, Yonemori K1, Shimizu C1, Fujiwara Y1, Tamura K2. Anticancer Res. 2016 May;36(5):2429-32.
BACKGROUND: No standard chemotherapy for adults with recurrent/refractory rhabdomyosarcoma (RMS) has yet been established. The present study aimed to assess the effect of ifosfamide and etoposide (IE) chemotherapy on previously treated RMS.
3.Comparison of cisplatin/etoposide versus carboplatin/etoposide concurrent chemoradiation therapy for limited-stage small cell lung cancer (LS-SCLC) in the elderly population (age >65 years) using national SEER-Medicare data.
Kim E1, Biswas T2, Bakaki P3, Dowlati A4, Sharma N4, Machtay M5. Pract Radiat Oncol. 2016 Jan 28. pii: S1879-8500(16)00013-8. doi: 10.1016/j.prro.2016.01.011. [Epub ahead of print]
PURPOSE: Standard therapy for limited-stage small cell lung cancer (SCLC) (American Joint Committee on Cancer stages I-III) is concurrent chemoradiation therapy (CRT) with cisplatin/etoposide (EP), but carboplatin/etoposide (EC) is often used in clinical practice. Though a growing proportion of this disease is diagnosed in older patients, there are limited studies of older patients comparing cisplatin to carboplatin. This study compared survival outcomes of elderly patients with limited-stage SCLC treated with concurrent EC or EP and radiation.
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CAS 33419-42-0 Etoposide

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