Etomidate - CAS 33125-97-2
Catalog number: 33125-97-2
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
GABA Receptor
Etomidate is a GABAA receptor agonist, used as a short-acting anaesthetic agent or sedative.
Publictions citing BOC Sciences Products
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1.Effect of Etomidate Versus Combination of Propofol-Ketamine and Thiopental-Ketamine on Hemodynamic Response to Laryngoscopy and Intubation: A Randomized Double Blind Clinical Trial.
Gholipour Baradari A1, Firouzian A1, Zamani Kiasari A1, Aarabi M2, Emadi SA1, Davanlou A1, Motamed N3, Yousefi Abdolmaleki E4. Anesth Pain Med. 2016 Jan 10;6(1):e30071. doi: 10.5812/aapm.30071. eCollection 2016.
BACKGROUND: Laryngoscopy and intubation frequently used for airway management during general anesthesia, is frequently associated with undesirable hemodynamic disturbances.
2.The pituitary adenylate cyclase-activating polypeptide (PACAP) protects adrenal function in septic rats administered etomidate.
Liu N1, Zhang Y1, Xiong JY2, Liu S1, Zhu J3, Lv S4. Neuropeptides. 2016 Apr 4. pii: S0143-4179(16)30030-0. doi: 10.1016/j.npep.2016.03.005. [Epub ahead of print]
BACKGROUND: Both hyperinflammation during sepsis and etomidate can suppress adrenal function. In this study, we explored whether treatment with pituitary adenylate cyclase-activating polypeptide (PACAP) relieves adrenal suppression in cecal ligation and puncture (CLP)-induced septic rats.
3.Comparative study evaluating efficacy of sufentanil versus midazolam in preventing myoclonic movements following etomidate.
Alipour M1, Tabari M1, Azad AM1. J Anaesthesiol Clin Pharmacol. 2016 Jan-Mar;32(1):29-32. doi: 10.4103/0970-9185.173382.
BACKGROUND AND AIMS: Myoclonus is a major side-effect following etomidate injection requiring use of medical intervention.
4.Astrocytes contribute to the effects of etomidate on synaptic transmission in rat primary somatosensory cortex.
Yang H1, Wang Y2, Zhang Y2, Zhang Y1, Xu MS1, Yuan J1, Yu T3. Brain Res. 2016 Apr 1. pii: S0006-8993(16)30190-1. doi: 10.1016/j.brainres.2016.03.052. [Epub ahead of print]
Little is known about the mechanisms of unconsciousness induced by general anesthetics. Previous studies have shown that the primary somatosensory cortex (S1) is a sensitive region to a variety of intravenous general anesthetics. Etomidate is a widely used intravenous anesthetic that can influence synaptic transmission. Recently, there are some evidences suggesting that astrocytes, a type of glia cell, also contribute to information transmission in the brain, and modulate synaptic function by releasing neuroactive substances. However, it is unknown whether astrocytes influence the effects of etomidate on information transmission in S1 pyramidal neurons. In the present study, the role of astrocytes in etomidate-induced unconsciousness was investigated by using the whole-cell patch clamp technique. We observed etomidate at clinically relevant concentrations inhibited the spontaneous postsynaptic currents (sPSCs) of rat S1 pyramidal neurons in a concentration-dependent manner, and the EC50 value of etomidate for inhibiting sPSCs from the concentration-effect curve was 6.
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CAS 33125-97-2 Etomidate

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