Etofenamate - CAS 30544-47-9
Catalog number: B0084-065631
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C18H18F3NO4
Molecular Weight:
369.34
COA:
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Targets:
Others
Description:
Medication used to alleviate joint and muscle pain.
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Purity:
>98%
Synonyms:
2-[[3-(Trifluoromethyl)phenyl]amino]benzoic Acid 2-(2-Hydroxyethoxy)ethyl Ester; 2-(2-Hydroxyethoxy)ethyl Fufenamate; Bayrogel; Reumon; Rheumon; Traumon Gel
MSDS:
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1.Analytical Quality by Design Approach in RP-HPLC Method Development for the Assay of Etofenamate in Dosage Forms.
Peraman R1, Bhadraya K2, Reddy YP3, Reddy CS3, Lokesh T3. Indian J Pharm Sci. 2015 Nov-Dec;77(6):751-7.
By considering the current regulatory requirement for an analytical method development, a reversed phase high performance liquid chromatographic method for routine analysis of etofenamate in dosage form has been optimized using analytical quality by design approach. Unlike routine approach, the present study was initiated with understanding of quality target product profile, analytical target profile and risk assessment for method variables that affect the method response. A liquid chromatography system equipped with a C18 column (250×4.6 mm, 5 μ), a binary pump and photodiode array detector were used in this work. The experiments were conducted based on plan by central composite design, which could save time, reagents and other resources. Sigma Tech software was used to plan and analyses the experimental observations and obtain quadratic process model. The process model was used for predictive solution for retention time. The predicted data from contour diagram for retention time were verified actually and it satisfied with actual experimental data.
2.Development of etofenamate-loaded semisolid sln dispersions and evaluation of anti-inflammatory activity for topical application.
Badilli U, Sengel-Turk CT1, Onay-Besikci A, Tarimci N. Curr Drug Deliv. 2015;12(2):200-9.
Dermal application of various active substances is widely preferred for topical or systemic delivery. SLNs consist of biocompatible and non-toxic lipids and have a great potential for topical application in drugs. In this study, semisolid SLN formulations were successfully prepared by a novel one-step production method as a topical delivery system of etofenamate, an anti-inflammatory drug. Compritol 888 ATO and Precirol ATO 5 were chosen as lipid materials for the fabrication of the formulations. In-vitro evaluation of the formulations was performed in terms of encapsulation efficiency, particle size, surface charge, thermal behavior, rheological characteristics, in vitro drug release profile, kinetics, mechanisms, stability, and anti-inflammatory activity. The colloidal size and spherical shape of the particles were proved. According to the results of the rheological analysis, it was demonstrated that the semisolid SLN formulations have a gel-like structure.
3.[Acute inferior myocardial infarction after injection of etofenamate].
Tekin YK1, Tekin G. Turk Kardiyol Dern Ars. 2012 Dec;40(8):733-5. doi: 10.5543/tkda.2012.03592.
Allergic symptoms accompanied by myocardial ischemic symptoms are defined as Kounis syndrome. Etofenamate is a safe and effective non-steroidal antiinflammatory drug that has widespread utilization. We hereby present a 71-year-old man with Kounis syndrome. Following intramuscular 1 g etofenamate injection, the clinical presentation when admitted to the emergency department (ED) was erythematous rash, pruritus, nausea and vomiting, dizziness, diaphoresis, and chest pain resulting in cardiopulmonary arrest. After 10 minutes of successful cardiopulmonary resuscitation, the electrocardiogram revealed acute inferior myocardial infarction. Patients who admit to the ED with allergic symptoms accompanied by chest pain should consider Kounis syndrome for prompt management. Electrocardiographic examination should be an essential part of the initial evaluation in such patients.
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CAS 30544-47-9 Etofenamate

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