Ethyl β-D-ribo-hex-3-ulopyranoside - CAS 104953-08-4
Catalog number: 104953-08-4
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C8H14O6
Molecular Weight:
206.19
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Purity:
95%
Appearance:
Powder
Synonyms:
(2R,3S,5R,6R)-2-ethoxy-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-4H-pyran-4-one
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Quality Standard:
Enterprise Standard
Quantity:
Milligrams-Grams
1.Photochemical synthesis and anticancer activity of barbituric acid, thiobarbituric acid, thiosemicarbazide, and isoniazid linked to 2-phenyl indole derivatives.
Laxmi SV1, Rajitha G2, Rajitha B2, Rao AJ3. J Chem Biol. 2015 Nov 17;9(2):57-63. doi: 10.1007/s12154-015-0148-y. eCollection 2016.
2-Phenyl-1H-indole-3-carbaldehyde-based barbituric acid, thiobarbituric acid, thiosemicarbazide, isoniazid, and malononitrile derivatives were synthesized under photochemical conditions. The antitumor activities of the synthesized compounds were evaluated on three different human cancer cell lines representing prostate cancer cell line DU145, Dwivedi (DWD) cancer cell lines, and breast cancer cell line MCF7. All the screened compounds possessed moderate anticancer activity, and out of all the screened compounds, 5-{1[2-(4-chloro-phenyl)2-oxo-ethyl]-2-phenyl-1H-indole-3-ylmethylene}-2-thioxo-dihydro-pyrimidine-4,6-dione (2b) and 5-{1[2-(4-methoxy-phenyl)2-oxo-ethyl]-2-phenyl-1H-indole-3-ylmethylene}-2-thioxo-dihydro-pyrimidine-4,6-dione (2d) exhibited marked antitumor activity against used cell lines. Additionally, barbituric acid derivatives were selective to inhibit cell line DWD and breast cancer cell lines.
2.Ethyl Pyruvate Ameliorates The Damage Induced by Cyclophosphamide on Adult Mice Testes.
Bakhtiary Z1, Shahrooz R1, Ahmadi A1, Soltanalinejad F1. Int J Fertil Steril. 2016 Apr-Jun;10(1):79-86. Epub 2016 Apr 5.
BACKGROUND: Cyclophosphamide (CP) is a chemotherapy drug which causes deleterious effects on testicular tissue and increases free radicals in the body. The aim of this study is to investigate the protective effects of ethyl pyruvate (EP) on testicular improvement in CP treated animals.
3.Biocatalytic properties and structural analysis of eugenol oxidase from Rhodococcus jostii RHA1: a versatile oxidative biocatalyst.
Nguyen QT1, De Gonzalo G2, Binda C3, Rioz A4, Mattevi A5, Fraaije M6. Chembiochem. 2016 Apr 28. doi: 10.1002/cbic.201600148. [Epub ahead of print]
Eugenol oxidase (EUGO) from Rhodococcus jostii RHA1 was previously shown to convert only a limited set of phenolic compounds. In this study, we have explored the biocatalytic potential of this flavoprotein oxidase resulting in a broadened substrate scope and a deeper insight into its structural properties. In addition to the oxidation of vanillyl alcohol and hydroxylation of eugenol, EUGO can efficiently perform the dehydrogenation of various phenolic ketones and the selective oxidation of a racemic secondary alcohol, 4-(hydroxy-1-ethyl)-2-methoxyphenol. EUGO was also found to perform the kinetic resolution of a racemic secondary alcohol. Crystal structures of the enzyme in complex with isoeugenol, coniferyl alcohol, vanillin, and benzoate have been determined. The catalytic center is a remarkable solvent-inaccessible cavity on the si side of the flavin cofactor. Structural comparison with vanillyl-alcohol oxidase from Penicillium simplicissimum highlights a few localized changes that correlate with the selectivity of EUGO for phenolic substrates bearing relatively small p-substituents while allowing o-methoxy substituents.
4.Roles of subunit NuoL in the proton pumping coupling mechanism of NADH:ubiquinone oxidoreductase (complex I) from Escherichia coli.
Narayanan M1, Sakyiama JA1, Elguindy MM1, Nakamaru-Ogiso E2. J Biochem. 2016 Apr 26. pii: mvw027. [Epub ahead of print]
Respiratory complex I has an L-shaped structure formed by the hydrophilic arm responsible for electron transfer and the membrane arm that contains protons pumping machinery. Here, to gain mechanistic insights into the role of subunit NuoL, we investigated the effects of Mg2+, Zn2+, and the Na+/H+ antiporter inhibitor 5-(N-ethyl-N-isopropyl)-amiloride (EIPA) on proton pumping activities of various isolated NuoL mutant complex I after reconstitution into E. coli double knockout (DKO) membrane vesicles lacking complex I and the NADH dehydrogenase type 2. We found that Mg2+ was critical for proton pumping activity of complex I. At 2 μM Zn2+, proton pumping of the wild-type was selectively inhibited without affecting electron transfer; no inhibition in proton pumping of D178N and D400A were observed, suggesting the involvement of these residues in Zn2+ binding. 15 μM EIPA caused up to ~40% decrease in the proton pumping activity of the wild-type, D303A and D400A/E, while no significant change was detected in D178N, indicating its possible involvement in the EIPA binding.
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CAS 104953-08-4 Ethyl β-D-ribo-hex-3-ulopyranoside

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