Ethamsylate - CAS 2624-44-4
Catalog number:
2624-44-4
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C6H6O5S.C4H11N
Molecular Weight:
263.31
COA:
Inquire
Targets:
Prostaglandin Receptor
Description:
Ethamsylate is a haemostatic drug, which inhibits biosynthesis and action of prostaglandins, and increases capillary endothelial resistance as and platelet adhesion.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Synonyms:
Etamsylate
MSDS:
Inquire
1.Recombinant factor VIIa use in patients with the rarest forms of inherited coagulation-factor deficiencies: a study of cases from the www.haemostasis.com registry
P. Smejkal & M. Hassan & J. Ingerslev. Comp Clin Pathol (2006) 15:203–210
During the second bleeding episode that occurred 5 days later, two doses of 80 μg/kg body weight rFVIIa were administered at an interval of 4 h (total dose: 160 μg/kg body weight) and bleeding markedly decreased 1 h after the second dose. Etamsylate and vitamin K were also given at unspecified doses. Additional treatments comprised Ringer’s lactate (500 ml) and 2 U of PRBCs in the 24-h period before rFVIIa administration and Ringer’s lactate (1,000 ml) and 2 U FFP in the 24-h period after rFVIIa administration. The patient’s outcome after the second bleeding episode was described as “excellent”, and the case provider commented that the treatment was “life saving”.
2.Successful therapeutic management of canine Isosporosis in puppies
Nishiswapna Garanayak • A. R. Gupta • R. C. Patra. J Parasit Dis
The puppies were administered with trimethoprime and sulphamethoxazole @ 40 mg/kg body weight in combination with metronidazole @ 10 mg/kg body weight twice daily for 5 days. As supportive therapy plasma expander @ 5 ml/kg body weight for 3 days along with Ringer’s Lactate @ 30 ml/kg body weight twice daily for 5 days were given. Dextrose was administerd to the puppies to provide the energy @ 0.5 mg/kg body wt. Antiemetic metoclo- pramide @ 0.4 mg/kg body weight and haemocoagulase etamsylate @ 250 mg twice daily was given for 2 days.
3.PREFORMULATION COMPATIBILITY STUDIES OF ETAMSYLATE AND FLUCONAZOLE DRUGSWITH LACTOSE BY DSC
S. R. Desai, M. M. Shaikh and S. R. Dharwadkar*. Journal of Thermal Analysis and Calorimetry, Vol. 71 (2003) 651–658
It can be seen from this table that in the case of etamsylate–lactose mixture an additional prominent endothermic peak appeared at 118.5 and the main peak at 136.7°C in original etamsylate shifted to lower temperature of 131.4°C, probably due to solid solubility of lactose in etamsylate. Similarly, the mixture of fluconazole and lactose showed additional peaks at 86.1 and 136.4°C respectively in addition to the peak corresponding to the melting of pure drug at 140.2°C indicating partial interaction of the drug with the excipient. The additional DSC peaks observed for the mixtures which are not present in the DSC patterns recorded for pure drugs and excipients could have resulted from the chemical interaction of the drugs with excipients.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Prostaglandin Receptor Products


GSK-345931A
(CAS: 869534-13-4)

GSK-345931A is an EP(1) receptor antagonist. It is efficient in preclinical models of inflammatory pain.

PF-4217329
(CAS: 1005549-94-9)

PF-04217329 is a potent and selective EP2 receptor agonist on intraocular pressure in preclinical models of glaucoma. It is a prodrug of CP-544326. It is well t...

CAS 571170-77-9 Laropiprant

Laropiprant
(CAS: 571170-77-9)

Laropiprant is a potent, selective DP1 receptor antagonist (Ki=0.57 nM) used in combination with niacin to reduce blood cholesterol (LDL and VLDL).

CAS 1006036-87-8 MK-2894

MK-2894
(CAS: 1006036-87-8)

MK-2894, a nonacylsulfonamide analogue, is a high affinity full antagonist against the EP4 receptor. It is found to have conceivable potency and selectivity for...

CAS 752187-80-7 CP 544326

CP 544326
(CAS: 752187-80-7)

CP 544326, also known as taprenepag, is a potent and selective EP(2) receptor agonist. Its EC50 value is 2.8 nM. It is the active acid metabolite of the prodrug...

Omidenepag
(CAS: 1187451-41-7)

This active molecular is a prostaglandin receptor agonist and detailed information has not been published yet.

CAS 1175526-27-8 AM-211

AM-211
(CAS: 1175526-27-8)

This active molecular is a potent Prostaglandin D2 receptor antagonists and has been in phase I clinical trials for both COPD (chronic obstructive pulmonary dis...

MF592
(CAS: 1064195-48-7)

MF592 is a potent and selective antagonists of the EP4 receptor. It has good functional potency and potent inhibition of PGE2 modulated TNFa release in LPS stim...

CAS 851204-35-8 EP1-antanoist-1

EP1-antanoist-1
(CAS: 851204-35-8)

A EP1 antagonist (pKi= 7.54) (pIC50= 8.5)

CAS 892549-43-8 Mf-63

Mf-63
(CAS: 892549-43-8)

Mf-63 is a selective Microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor. Its IC50 value is 0.9 nM and 1.3 nM for pig mPGES-1 and human mPGES-1 enzyme, r...

CAS 1369489-71-3 E7046

E7046
(CAS: 1369489-71-3)

E7046 is an orally bioavailable and specific type 4 prostaglandin E2 (PGE2) receptor EP antagonist (IC50= 13.5 nM) (Ki= 23.14 nM), with anti-tumor activities.

CAS 72814-32-5 BW 245C

BW 245C
(CAS: 72814-32-5)

BW 245C, a prostaglandin analogue, is a selective prostanoid DP-receptor (DP1)agonist used to treat stroke where the Ki for the inhibition of [3H]-PGD2 binding ...

CAS 143443-90-7 Ifetroban

Ifetroban
(CAS: 143443-90-7)

Ifetroban is a selective Prostaglandin receptor and Thromboxane A2 receptor antagonist under the development of Bristol-Myers Squibb. Phase II clinical trials f...

GSK-345931A sodium
(CAS: 869499-38-7)

GSK-345931A is an EP(1) receptor antagonist. It is efficient in preclinical models of inflammatory pain.

CAS 55028-72-3 Cloprostenol sodium

Cloprostenol sodium
(CAS: 55028-72-3)

Cloprostenol sodium is a synthetic and water-soluble aryl-oxymethyl analog of prostaglandin F2α. lt is also a potent inhibitor of rat adipose precursor differen...

AM-211 sodium
(CAS: 1263077-74-2)

This active molecular is a potent Prostaglandin D2 receptor antagonists and has been in phase I clinical trials for both COPD (chronic obstructive pulmonary dis...

CAS 402473-54-5 ONO-AE3-208

ONO-AE3-208
(CAS: 402473-54-5)

ONO-AE3-208 is an EP4 antagonist (Ki values are 1.3, 30, 790 and 2400 nM for EP4, EP3, FP and TP receptors respectively), which less potently affects EP3, FP, a...

CAS 62561-03-9 (+)-Cloprostenol sodium salt

(+)-Cloprostenol sodium salt
(CAS: 62561-03-9)

(+)-Cloprostenol sodium salt is the d-enantiomer of Cloprostenol, which is an aryl-oxymethyl analog of prostaglandin F2α. It has luteolytic effects and is used ...

PF-04418948
(CAS: 1078166-57-0)

PF-04418948 is a potent and selective prostaglandin EP₂ receptor antagonist with IC50 of 16 nM. Phase 1. PF-04418948 antagonizes the effects of butaprost and PG...

Terutroban
(CAS: 165538-40-9)

Terutroban is a potent, orally active antagonist of the thromboxane/prostaglandin A2(TP) receptor (IC50 = 16.4 nM). In guinea pigs it also inhibits U 46619 indu...

Chemical Structure

CAS 2624-44-4 Ethamsylate

Quick Inquiry

Verification code

Featured Items