Ethacridine lactate monohydrate - CAS 6402-23-9
Catalog number: 6402-23-9
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C15H15N3O·C3H6O3·H2O
Molecular Weight:
361.39
COA:
Inquire
Targets:
Antifungal
Description:
Ethacridine lactate monohydrate is an aromatic organic compound based on acridine used as an antiseptic agent.
Purity:
>98%
Synonyms:
AMN-107; AMN107; AMN107
MSDS:
Inquire
InChIKey:
NYEPHMYJRNWPLA-UHFFFAOYSA-N
InChI:
InChI=1S/C15H15N3O.C3H6O3.H2O/c1-2-19-10-4-6-13-12(8-10)15(17)11-5-3-9(16)7-14(11)18-13;1-2(4)3(5)6;/h3-8H,2,16H2,1H3,(H2,17,18);2,4H,1H3,(H,5,6);1H2
Canonical SMILES:
CCOC1=CC2=C(C3=C(C=C(C=C3)N)N=C2C=C1)N.CC(C(=O)O)O.O
1.Kinetic and mechanistic analyses of new classes of inhibitors of two-component signal transduction systems using a coupled assay containing HpkA-DrrA from Thermotoga maritima.
Foster JE;Sheng Q;McClain JR;Bures M;Nicas TI;Henry K;Winkler ME;Gilmour R Microbiology. 2004 Apr;150(Pt 4):885-96.
Two-component signal transduction systems (TCSs) play fundamental roles in bacterial survival and pathogenesis and have been proposed as targets for the development of novel classes of antibiotics. A new coupled assay was developed and applied to analyse the kinetic mechanisms of three new kinds of inhibitors of TCS function. The assay exploits the biochemical properties of the cognate HpkA-DrrA histidine kinase-response regulator pair from Thermotoga maritima and allows multiple turnovers of HpkA, linear formation of phosphorylated DrrA, and Michaelis-Menten analysis of inhibitors. The assay was validated in several ways, including confirmation of competitive inhibition by adenosine 5'-beta,gamma-imidotriphosphate (AMP-PNP). The coupled assay, autophosphorylation and chemical cross-linking were used to determine the mechanisms by which several compounds inhibit TCS function. A cyanoacetoacetamide showed non-competitive inhibition with respect to ATP concentration in the coupled assay. The cyanoacetoacetamide also inhibited autophosphorylation of histidine kinases from other bacteria, indicating that the coupled assay could detect general inhibitors of histidine kinase function. Inhibition of HpkA autophosphorylation by this compound was probably caused by aggregation of HpkA, consistent with a previous model for other hydrophobic compounds.
2.Ethodin: pharmacological evidence of the interaction between smooth muscle and mast cells in the myometrium.
Rudolph MI;de los Angeles García M;Sepulveda M;Brandan E;Reinicke K;Nicovani S;Villan L J Pharmacol Exp Ther. 1997 Jul;282(1):256-61.
Ethodin has been used to induce labor through a mechanism that does not involve the estrogen-preparatory process being postulated as necessary for ensuring the events in a normal labor. The cellular mechanisms involved in that process are unknown. We used an isolated organ bath preparation for mouse uterine horns and a primary culture of mouse myometrial smooth muscle cells to analyze the cellular mechanisms involved in the contractile action of this drug in the myometrium. Ethodin at a concentration of 10 microM and Compound 48/80 (1 microg/ml) evoked contractions of uterine horns in an isolated organ bath preparation. Uterine contractile responses showed a transient increase in contractile tension that lasted 2 to 3 min. Tachyphylaxis was observed after four or five successive stimuli, which consisted in additions and washings of the drug at an interval of 10 min. The primary smooth muscle mouse myometrium cells contained a high proportion of relaxed cells that varied widely in length (5-160 microm). Cell lengths decreased in response to the application of serotonin (10 microM) and oxytocin (0.1 microM) but were not affected after the addition of ethodin (10 microM). However, the cells contracted after a purified fraction of mast cells that had been degranulated by the action of the drug ethodin, which was added to the culture medium.
3.Effects of vesicular acetylcholine uptake blockers on frequency augmentation-potentiation in frog neuromuscular transmission.
Maeno T;Enomoto K Neuroscience. 1994 Mar;59(2):487-93.
Vesamicol inhibits the vesicular loading of acetylcholine molecules. The effects of vesamicol and similarly acting compounds on neuromuscular transmission in frogs were investigated to determine whether these inhibitors-inhibit the frequency augmentation-potentiation of transmitter release. Various vesicular acetylcholine transport blockers suppressed the stimulation frequency-related release parameter, k, in a dose-dependent manner. Artane, cetiedil, chloroquine, ethodin, quinacrine, vesamicol and its benzyl-analogue, 2-(4-benzylpiperidino)cyclohexanol, had strong effects, while those of aminacrine, chlorpromazine, fluphenazine, imipramine, pyrilamine and thioridazine were weak. A significant correlation was observed between the biochemically reported values of IC50 and the electrophysiological inhibitory potencies on k at 20 microM. Contrary to expectations from the biochemical data, however, vesamicol and its benzyl-analogue showed equipotent inhibitory actions on the electrophysiological frequency augmentation-potentiation relation. Low sensitivity and low selectivity of the frequency augmentation-potentiation for vesamicol and its benzyl-analogue lead us to conclude that the vesicular acetylcholine transporter is not the site of the electrophysiological action of vesamicol and similarly acting chemicals.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Antifungal Products


CAS 38083-17-9 Climbazole

Climbazole
(CAS: 38083-17-9)

Climbazole is a topical antifungal agent commonly used in the treatment of human fungal skin infections such as dandruff and eczema. Climbazole has shown a high...

CEF3

CEF3 (SIIPSGPLK) corresponds to aa 13-21 of the influenza A virus M1 protein, and was first described in the yeast Saccharomyces cerevisiae and has subsequently...

CAS 211867-47-9 Flumorph

Flumorph
(CAS: 211867-47-9)

Flumorph did not inhibit the synthesis of cell wall materials, but disturbed the polar deposition of newly synthesized cell wall materials during cystospore ger...

CAS 104987-12-4 Ascomycin (FK520)

Ascomycin (FK520)
(CAS: 104987-12-4)

Ascomycin, isolated from Streptomyces, suppresses immune response in vitro with IC50 of 0.55 nM for mouse mixed lymphocyte.

CAS 110588-57-3 R66905

R66905
(CAS: 110588-57-3)

R66905, also known as saperconazole, is a broad-spectrum antifungal triazole.

CAS 22832-87-7 Miconazole Nitrate

Miconazole Nitrate
(CAS: 22832-87-7)

Miconazole is an imidazole antifungal agent, developed by Janssen Pharmaceutica, commonly applied topically to the skin or to mucous membranes to cure fungal in...

CAS 65473-14-5 Naftifine HCl

Naftifine HCl
(CAS: 65473-14-5)

Naftifine is an allylamine antifungal drug for the topical treatment of tinea pedis, tinea cruris, and tinea corporis, probably involves selectively blocking st...

CAS 208538-73-2 Micafungin Sodium

Micafungin Sodium
(CAS: 208538-73-2)

Micafungin Sodium is an inhibitor of 1, 3-beta-D-glucan synthesis, used as an antifungal drug.

Chemical Structure

CAS 6402-23-9 Ethacridine lactate monohydrate

Quick Inquiry

Verification code

Featured Items