|Description||Eszopiclone is an active stereoisomer of zopiclone with hypnotic and sedative activity and without significant anxiolytic activity. Eszopiclone is a GABA A receptor agonist. It is able to bind to and activate the omega-1 subtype of the alpha subunit of the GABA receptor complex. This leads to the opening of chloride channels, causing hyperpolarization, inhibition of neuronal firing, and enhancement of the inhibitory effect of GABA. Eszopiclone is an approved for the treatment of insomnia. It is a controlled substance (depressant) in the US but not in Canada.|
|Appearance||White To Pale Yellow Solid|
|Synonyms||Lunesta; (S)-Zopiclone; Estorra; Esopiclone;[(7S)-6-(5-chloropyridin-2-yl)-5-oxo-7H-pyrrolo[3,4-b]pyrazin-7-yl] 4-methylpiperazine-1-carboxylate|
|Solubility||Acetone, Chloroform, Ethanol, Phosphate Buffer (pH 3.2),|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Boiling Point||No Data Available|
|Current Developer||Eisai Co Ltd; Sepracor; Sunovion Pharmaceuticals|
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