Estriol - CAS 50-27-1
Catalog number:
B0084-093184
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C18H24O3
Molecular Weight:
288.387
COA:
Inquire
Targets:
Estrogen Receptor/ERR
Description:
Estriol is a metabolite of 17β-estradiol with much lower biological activity. It is the primary estrogen found in the urine. Large quantities of estriol and estrone are produced by the placenta during pregnancy. These are also the primary estrogens produced by adipose tissue in men and in post-menopausal women.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-093184 20 g $199 In stock
Bulk Inquiry
Publictions citing BOC Sciences Products
  • >> More
Brife Description:
metabolite of 17β-estradiol
Purity:
0.98
Synonyms:
16α-hydroxy-17β-estradiol; 1,3,5(10)-Estratriene-3,16α, 17β-triol; E3; Oestriol; Ovestin; Estratriol; Ovestrion
Solubility:
Water: 27.34 mg/L
MSDS:
Inquire
Melting Point:
282 °C
InChIKey:
PROQIPRRNZUXQM-ZXXIGWHRSA-N
InChI:
InChI=1S/C18H24O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-17,19-21H,2,4,6-7,9H2,1H3/t13-,14-,15+,16-,17+,18+/m1/s1
Canonical SMILES:
CC12CCC3C(C1CC(C2O)O)CCC4=C3C=CC(=C4)O
1. A direct competitive inhibition time-resolved fluoroimmunoassay for the detection of unconjugated estriol in serum of pregnant women
Yong-ping Tang, Su-qing Zhao,* Ying-song Wu, Jian-wei Zhouc and Ming Li*. Anal. Methods, 2013, 5, 4068–4073
E3-3-carboxymethyl ether (E3-3-CME) was prepared by alkylation of estriol with bromoacetic acid. To a solution of estriol (100mg, 0.34 mmol) in 2.0 mL of DMSO (dimethylsulfoxide), dry powdered KOH was added (0.34mg, 6mmol). After stirring for 5 minutes, bromoacetic acid (100 mg, 0.715 mmol) was added. Stirring was continued for 2 hours and the reaction mixture was poured into ice cold water (17 mL). It was extracted with ethyl acetate to recover unreacted estriol. The aqueous solution was cooled and acidified with dilute HCl (2 M) and the resulting precipitate was filtered. The precipitate was washed with water till neutral.
2. The A-CD analogue of 16β,17α-estriol is a potent and highly selective estrogen receptorβagonist
Claire Sauvee, Anja Schafer, oger Olsson*. Med. Chem. Commun., 2013, 4, 1439–1442
Estriol shows neuroprotection in mice and clinical phase II and III studies are ongoing in humans for MS. However, we were more attracted by the 16β,17α-isomer of estriol (16,17-epi-estriol) because it had been reported to have a higher ERb selectivity both in a functional assay (EC50:ERα 72 nM; ERβ:11nM) and in binding affinity (RBA ERα: 1%; ERβ: 13%). The two other estriol hydroxyl isomers, 17-epiestriol and 16-epi-estriol, both display equal affinity to ERβ and ERα.
3. cis-Diol functional group recognition by reactive desorption electrospray ionization (DESI)
Hao Chen, Ismael Cotte-Rodrıguez and R. Graham Cooks*. Chem. Commun., 2006, 597–599
Other biologically-active aliphatic diols examined were 1,3,5(10)-estratrien-3,16α,17α-triol (cis-estriol) and 1,3,5(10)-estratrien-3,16α,17β-triol (trans-estriol). Differentiation of cis- and trans-diols by conventional ion/molecule reactions with phosphenium ions and trimethyl-Group 14 cations in the mass spectrometer has been reported. The major difference in the present reactive DESI study from the previous reports is that the estriol sample was present as the solid on a surface and the reaction was performed under ambient conditions, making it easier to manipulate the sample and perform the practical application.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Estrogen Receptor/ERR Products


CAS 95167-41-2 DY131

DY131
(CAS: 95167-41-2)

DY131 is a novel selective agonist of ERRβ and ERRγ, which displays minimal activity at ERRα, ERα and ERβ at concentrations up to 30 μM. It could potentiate the...

CAS 524684-52-4 ERB-041

ERB-041
(CAS: 524684-52-4)

ERB 041 is a highly selective agonist of the ERβ subtype of the estrogen receptor, displays >200-fold selectivity for ERβ over Erα.

CAS 725247-18-7 XCT 790

XCT 790
(CAS: 725247-18-7)

XCT-790 is a potent, selective ERRα antagonist/inverse agonist (IC50 = ~400 nM), displaying no antagonist activity at ERRγ or ERα at concentrations below 10 μM.

CAS 50-41-9 Clomifene citrate

Clomifene citrate
(CAS: 50-41-9)

Clomifene Citrate is a selective estrogen receptor modulator used in the treatment of ovulation induction. It is used to treat breast cancer for its antineoplas...

Elacestrant S enantiomer dihydrochloride

Elacestrant S enantiomer dihydrochloride is an low activity enantiomer of elacestrant dihydrochloride. Elacestrant, also referred to RAD1901, is a selective and...

CAS 112093-28-4 Endoxifen

Endoxifen
(CAS: 112093-28-4)

Endoxifen, a significant metamolite of Tamoxifen, is a regulator of estrogen receptor and could be effective in the treatment of estrogen-dependent breast cance...

CAS 1428-67-7 Diarylpropionitrile

Diarylpropionitrile
(CAS: 1428-67-7)

Diarylpropionitrile, also called as DPN, is a selective agonist of estrogen receptor β (ERβ) with a 70-fold higher relative binding affinity for ERβ(18%) versus...

CAS 434-03-7 Ethisterone

Ethisterone
(CAS: 434-03-7)

Ethisterone is a progestogen hormone being considered to treat prostate cancer.It was the first orally-active progestin.

CAS 198481-33-3 Bazedoxifene acetate

Bazedoxifene acetate
(CAS: 198481-33-3)

Bazedoxifene acetate, also called as TSE424 or WAY-140424, with antiosteoporotic it is a selective nonsteroidal estrogen receptor modulator (SERM) (ERα: IC50= 2...

CAS 50-50-0 Estradiol Benzoate

Estradiol Benzoate
(CAS: 50-50-0)

Estradiol benzoate is an estradiol analog which binds to the human, murine and chicken ERα with IC50 of 22-28 nM.

CAS 569-57-3 Chlorotrianisene

Chlorotrianisene
(CAS: 569-57-3)

Chlorotrianisene is a powerful synthetic, non-steroidal estrogenic compound which is metabolized by liver microsomal enzymes primarily to the mono-O-demethylate...

SNG-1153
(CAS: 1446712-19-1)

SNG-1153, derived from icaritin which is purified from Epimedium Genus, modulates ER-α36 and induces β-catenin phosphorylation and then down-regulates β-catenin...

BHPI
(CAS: 56632-39-4)

BHPI is an antagonist of estrogen receptor α (ERα), for it elicits sustained ERα-dependent activation of the endoplasmic reticulum (EnR) stress sensor.

CAS 50-27-1 Estriol

Estriol
(CAS: 50-27-1)

Estriol is a metabolite of 17β-estradiol with much lower biological activity. It is the primary estrogen found in the urine. Large quantities of estriol and est...

CAS 50-28-2 Estradiol

Estradiol
(CAS: 50-28-2)

Estradiol, or more precisely, 17β-estradiol, is a human sex hormone and steroid, and the primary female sex hormone. It is essential for the maintenance of fert...

CAS 722533-56-4 Elacestrant

Elacestrant
(CAS: 722533-56-4)

Elacestrant, also referred to RAD1901, is a selective and orally available estrogen receptor (ERR) degrader (IC50= 48 and 870 nM for ERα and ERβ, respectively) ...

AZD9496
(CAS: 1639042-08-2)

AZD9496 is a potent and orally bioavailable selective estrogen receptor downregulator and antagonist. AZD9496 can induce ERα degradation in breast cancer cell l...

CAS 7280-37-7 Estropipate

Estropipate
(CAS: 7280-37-7)

Estropipate is an estrogen receptor agonist used in post-menopausal women for hormonal replacement therapy, with benefits to improved cognition and prevention o...

CAS 57-63-6 Ethinyl Estradiol

Ethinyl Estradiol
(CAS: 57-63-6)

Ethinyl Estradiol is a derivative of 17β-estradiol (E2), the major endogenous estrogen in humans. EE2 is an orally bioactive estrogen used in many formulations ...

CAS 26538-44-3 α-Zearalanol

α-Zearalanol
(CAS: 26538-44-3)

α-Zearalanol, derived from fungi in the Fusarium family, is a non-steroidal estrogen agonist that increases cancer cell proliferation in already existing breast...

Chemical Structure

CAS 50-27-1 Estriol

Quick Inquiry

Verification code

Featured Items