Estramustine - CAS 2998-57-4
Catalog number:
2998-57-4
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C23H31Cl2NO3
Molecular Weight:
440.4
COA:
Inquire
Targets:
Others
Description:
Estramustine, a derivative of estradiol, is an alkylating antineoplastic agent that is used in the treatment of prostate cancer throughout the world.
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Purity:
≥98%
Appearance:
Crystalline solid
Synonyms:
[(8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl] N,N-bis(2-chloroethyl)carbamate;
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
Used treatment of breast cancer. Also used in the treatment of prostate cancer.
Quality Standard:
Enterprise standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly.
Quantity:
Milligrams-Grams
InChIKey:
FRPJXPJMRWBBIH-RBRWEJTLSA-N
InChI:
1S/C23H31Cl2NO3/c1-23-9-8-18-17-5-3-16(29-22(28)26(12-10-24)13-11-25)14-15(17)2-4-19(18)20(23)6-7-21(23)27/h3,5,14,18-21,27H,2,4,6-13H2,1H3/t18-,19-,20+,21+,23+/m1/s1
Canonical SMILES:
CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)OC(=O)N(CCCl)CCCl
1.Androgen-deprivation therapy plus chemotherapy in metastatic hormone-sensitive prostate cancer. A systematic review and meta-analysis of randomized clinical trials.
Ramos-Esquivel A1, Fernández C2, Zeledón Z3. Urol Oncol. 2016 Apr 1. pii: S1078-1439(16)00085-5. doi: 10.1016/j.urolonc.2016.03.003. [Epub ahead of print]
OBJECTIVE: To assess the efficacy and toxicity of androgen-deprivation therapy (ADT) plus chemotherapy in patients with hormone-sensitive metastatic prostate cancer.
2.Effective and Safe Administration of Low-Dose Estramustine Phosphate for Castration-Resistant Prostate Cancer.
Inoue T1, Ogura K2, Kawakita M3, Tsukino H4, Akamatsu S1, Yamasaki T1, Matsui Y1, Segawa T5, Sugino Y3, Kamoto T4, Kamba T1, Tanaka S6, Ogawa O7. Clin Genitourin Cancer. 2016 Feb;14(1):e9-e17. doi: 10.1016/j.clgc.2015.08.008. Epub 2015 Sep 2.
BACKGROUND: We evaluated the efficacy and safety of low-dose estramustine phosphate (EMP) in Japanese patients with castration-resistant prostate cancer (CRPC).
3.Concurrent chemoradiation for high-risk prostate cancer.
Cooper BT1, Sanfilippo NJ1. World J Clin Oncol. 2015 Aug 10;6(4):35-42. doi: 10.5306/wjco.v6.i4.35.
There are estimated to be 220800 cases of prostate cancer diagnosed in 2015, making up 26% of all cancer diagnoses. Fortunately, adenocarcinoma of the prostate is often a highly treatable malignancy. Even though the majority of prostate cancer patients present with localized disease, prostate cancer still accounts for over 27000 deaths a year. There is a subset of patients that are likely to recur after locoregional treatment that is thought of as a "high-risk" population. This more aggressive subset includes patients with clinical stage greater than T2b, Gleason score greater than 7, and prostate specific antigen greater than 20 ng/dL. The rate of biochemical relapse in this high risk group is 32%-70% within five years of definitive focal therapy. Given these discouraging outcomes, attempts have been made to improve cure rates by radiation dose escalation, addition of androgen depravation therapy, and addition of chemotherapy either sequentially or concurrently with radiation.
4.A Phase 3 Trial of 2 Years of Androgen Suppression and Radiation Therapy With or Without Adjuvant Chemotherapy for High-Risk Prostate Cancer: Final Results of Radiation Therapy Oncology Group Phase 3 Randomized Trial NRG Oncology RTOG 9902.
Rosenthal SA1, Hunt D2, Sartor AO3, Pienta KJ4, Gomella L5, Grignon D6, Rajan R7, Kerlin KJ8, Jones CU9, Dobelbower M10, Shipley WU11, Zeitzer K12, Hamstra DA13, Donavanik V14, Rotman M15, Hartford AC16, Michalski J17, Seider M18, Kim H19, Kuban DA20, Mou Int J Radiat Oncol Biol Phys. 2015 Oct 1;93(2):294-302. doi: 10.1016/j.ijrobp.2015.05.024. Epub 2015 Jul 21.
PURPOSE: Long-term (LT) androgen suppression (AS) with radiation therapy (RT) is a standard treatment of high-risk, localized prostate cancer (PCa). Radiation Therapy Oncology Group 9902 was a randomized trial testing the hypothesis that adjuvant combination chemotherapy (CT) with paclitaxel, estramustine, and oral etoposide plus LT AS plus RT would improve overall survival (OS).
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CAS 2998-57-4 Estramustine

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