Estradiol - CAS 50-28-2
Catalog number: B0084-093185
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Estrogen Receptor/ERR
Estradiol, or more precisely, 17β-estradiol, is a human sex hormone and steroid, and the primary female sex hormone. It is essential for the maintenance of fertility and secondary sexual characteristics in females.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-093185 25 g $188 In stock
Bulk Inquiry
Publictions citing BOC Sciences Products
  • >> More
Brife Description:
human sex hormone, primary female sex hormone
White crystalline powder
Beta-Estradiol; 17beta-Estradiol; Oestradiol; Dihydrofolliculin
Water: 3.6 mg/L
human sex hormone
Melting Point:
178.5 °C
Canonical SMILES:
1. Fluorescence resonance energy transfer based aptasensor for the sensitive and selective detection of 17β-estradiol using a quantum dot-bioconjugate as a nano-bioprobe
Feng Long,* Hanchang Shi and Hongchen Wang. RSC Adv.,2014, 4,2935–2941
Accordingly, the storage stability of the proposed QD nano-bioprobe was investigated. When the QD nano-bioprobe was stored in a refrigerator at 4 oC and measured at 3 day intervals, the decrease in the average maximum signal response in the absence of the analyte was <10% for the 17β-estradiol aptamer after 45 days of storage. Meanwhile, even when the average signal response for the 17β-estradiol specific aptamer slightly decreased, the QD nano-biosensor specific response was unaffected because all measurements were normalized with respect to the blank signal at the beginning of the daily analysis, and the signal shifts in the blank and sample measurements were generally the same. Thus, the developed QD-based aptasensor had sufficient stability. The stability and robustness of the QD nano-bioprobe was highly advantageous compared with other assays reported for 17β-estradiol, which also indicated the reliability of the proposed aptasensor for 17β-estradiol measurements.
2. From "hemoabzymes" to "hemozymes": towards new biocatalysts for selective oxidations
J.-P. Mahy,* J.-D. Marechal and R. Ricoux. Chem. Commun., 2015, 51, 2476—2494
The four metalloporphyrin–estradiol conjugates bound to the antibody 7A3 with a 2/1 stoichiometry, showing that, despite the bulky porphyrin, the estradiol anchor was still well accommodated by the antibody. The dissociation constants for the 4 metalloporphyrin–estradiol–7A3 complexes remained quite good, when compared to the affinity of the antibody for estradiol (KD ≈ 10-9M), with respective KD values of 4× 10-7M and 2 × 10-6M for the Fe- and Mn(TMPyP)–estradiol–7A3 complexes and 2 × 10-6 M and 9 × 10-6M for the Fe– and Mn(TpSPP)–estradiol–7A3 complexes. The nature of the porphyrin (cationic or anionic), as well as that of the metal inserted had thus little influence on the association of the cofactor with the antibody.
3. A metabolomics study of the inhibitory effect of 17-beta-estradiol on osteoclast proliferation and differentiation
Xiaoyan Liu, Yanqiu Liu, Mengchun Cheng, Xiaozhe Zhanga and Hongbin Xiao*. Mol. BioSyst., 2015, 11,635—646
However, metabolomics studies on osteoporosis models mainly focus on the effect of estrogen deficiency on the metabolome, and the effects of estradiol intervention is little researched. In addition, current biofluid (blood, urine etc.)metabolomics studies could merely provide downstream consequences caused by estradiol exposure, while lack of site and cell-specific effects evaluation. Evaluation of site- and cell-specific effects is particularly important for understanding the interaction mechanism between stimulus and targets. Using well-designed in vitro assays would provide complementary evidence for the in vivo studies, and give an insight into the specific interaction mechanism between estradiol and osteoporosis-related cells.
4. Interfacial nano-biosensing in microfluidic droplets for high-sensitivity detection of low-solubility molecules
Maowei Dou, JoseMireles Garcıa Jr., Sihui Zhan* and XiuJun Li*. Chem. Commun., 2016, 52, 3470—3473
Recently, aptamer-based electrochemical biosensors and aptamer-based optical biosensors have been developed for simple estradiol detection. However, because 17b-estradiol is almost insoluble in water, watermiscible organic solvents are required in these methods to dissolve estradiol, and the distribution ratio of each component needs to be carefully optimized to ensure that estradiol is completely dissolved. Thus, these assays usually require multi-step complicated procedures. These limitations compromise the advantages of detection simplicity fromaptamers, and hinder the extensive application of such detection approaches.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Estrogen Receptor/ERR Products

CAS 89778-27-8 Toremifene citrate

Toremifene citrate
(CAS: 89778-27-8)

Toremifene citrate is a selective estrogen receptor modulator (SERM) that binds to estrogen receptors to inhibit the estrogen activity.

CAS 198481-33-3 Bazedoxifene acetate

Bazedoxifene acetate
(CAS: 198481-33-3)

Bazedoxifene acetate, also called as TSE424 or WAY-140424, with antiosteoporotic it is a selective nonsteroidal estrogen receptor modulator (SERM) (ERα: IC50= 2...

CAS 129453-61-8 Fulvestrant

(CAS: 129453-61-8)

Fulvestrant is an effective inhibitor of the growth of ER-positive MCF-7 (with IC50 of 0.29 nM) but with no effect on the growth of ER-negative BT-20 human brea...

CAS 68047-06-3 (Z)-4-Hydroxytamoxifen

(CAS: 68047-06-3)

(Z)-4-Hydroxytamoxifen is a metabolite of Tamoxifen and acts as an estrogen receptor antagonist. It exhibits more than 100-fold affinity over Tamoxifen. (Z)-4-H...

CAS 138090-06-9 (R,R)-THC

(CAS: 138090-06-9)

(R,R)-THC is a non-steroidal and selective estrogen receptor ligand. (R,R)-THC exhibits agonist activity at ERα receptor (Ki = 9.0 nM) and antagonist activity a...

CAS 82640-04-8 Raloxifene HCl

Raloxifene HCl
(CAS: 82640-04-8)

Raloxifene is an oral selective estrogen receptor modulator (SERM) that has estrogenic actions on bone and anti-estrogenic actions on the uterus and breast. It ...

CAS 434-03-7 Ethisterone

(CAS: 434-03-7)

Ethisterone is a progestogen hormone being considered to treat prostate cancer.It was the first orally-active progestin.

CAS 1428-67-7 Diarylpropionitrile

(CAS: 1428-67-7)

Diarylpropionitrile, also called as DPN, is a selective agonist of estrogen receptor β (ERβ) with a 70-fold higher relative binding affinity for ERβ(18%) versus...

CAS 524684-52-4 ERB-041

(CAS: 524684-52-4)

ERB 041 is a highly selective agonist of the ERβ subtype of the estrogen receptor, displays >200-fold selectivity for ERβ over Erα.

AZD9496 maleate
(CAS: 1639042-28-6)

AZD9496 maleate is potent downregulator of estrogen receptor in breast carcinoma cells and also antagonise ERα with good oral pharmacokinetic properties. It is ...

CAS 15690-57-0 trans-Clomiphene

(CAS: 15690-57-0)

Trans-Clomiphene, a stilbenes derivative, has been found to be an estrogen receptor antagonist as well as testosterone agonist. It has been developed for hypogo...

CAS 101574-65-6 GSK 4716

GSK 4716
(CAS: 101574-65-6)

GSK 4716 is a selective agonist of estrogen-related receptors ERRβ and ERRγ displaying selectivity over ERRα and the classical estrogen receptors. Activation of...

CAS 569-57-3 Chlorotrianisene

(CAS: 569-57-3)

Chlorotrianisene is a powerful synthetic, non-steroidal estrogenic compound which is metabolized by liver microsomal enzymes primarily to the mono-O-demethylate...

CAS 88431-47-4 Clomoxir

(CAS: 88431-47-4)

Clomoxir is a carnitine O-palmitoyltransferase inhibitor.

CAS 486-66-8 Daidzein

(CAS: 486-66-8)

Daidzein belongs to the group of isoflavones.Daidzein can be converted to its end metabolite S-equol in some humans based on the presence of certain intestinal ...

CAS 313-06-4 Estradiol Cypionate

Estradiol Cypionate
(CAS: 313-06-4)

Estradiol cypionate is the 17 β-cyclopentylpropinate ester of estradiol, which inhibits ET-1 synthesis via estrogen receptor.

CAS 343248-86-2 ERA63

(CAS: 343248-86-2)

A selective agonist of estrogen receptor α

(CAS: 1639042-08-2)

AZD9496 is a potent and orally bioavailable selective estrogen receptor downregulator and antagonist. AZD9496 can induce ERα degradation in breast cancer cell l...

CAS 50-28-2 Estradiol

(CAS: 50-28-2)

Estradiol, or more precisely, 17β-estradiol, is a human sex hormone and steroid, and the primary female sex hormone. It is essential for the maintenance of fert...

CAS 57-63-6 Ethinyl Estradiol

Ethinyl Estradiol
(CAS: 57-63-6)

Ethinyl Estradiol is a derivative of 17β-estradiol (E2), the major endogenous estrogen in humans. EE2 is an orally bioactive estrogen used in many formulations ...

Chemical Structure

CAS 50-28-2 Estradiol

Quick Inquiry

Verification code

Featured Items