|Description||ESI-09 is a specific exchange protein directly activated by cAMP (EPAC) inhibitor with IC50 of 3.2 μM and 1.4 μM for EPAC1 and EPAC2, respectively, >100-fold selectivity over PKA.ESI-09 is a novel noncyclic nucleotide EPAC antagonist that is capable of specifically blocking intracellular EPAC-mediated Rap1 activation and Akt phosphorylation, as well as EPAC-mediated insulin secretion in pancreatic β cells. EPAC1 plays an important role in pancreatic cancer cell migration and invasion, and thus represents a potential target for developing novel therapeutic strategies for pancreatic cancer.|
666-15 is a potent and selective inhibitor of CREB-mediated gene transcription (IC50= 81 nM) with efficacious in vitro and in vivo anti-breast cancer activity w...
Trelanserin is a serotonin receptor antagonist.
Amitraz is a non-systemic acaricide and insecticide, as an antiparasitic used to control red spider mites, leaf miners and scale insects.
A bioassay-guided isolation of the chloroform fraction of the I. britannica using an in vitro melanogenesis inhibition assay led to the isolation of sesquiterpe...
Gynostemma Extract is a saponins extract derived from the Gynostemma pentaphyllum.
Cloxyfonac is a plant growth regulator and a chemical transformation product.
Astragalus polysaccharide is one kind of biological macromolecule extracted from Astragalus. It has antiviral activities.
Azelaic acid, produced by ozone cracking of unsaturated fatty acid, could be commonly used in grease, cosmetics and pharmaceuticals.
Emodepside, also known as PF 1022-221, a semisynthetic derivative of PF1022A, is efficacious against a variety of gastrointestinal nematodes and used as an anth...
PROTO-1, a benzothiophene carboxamide, shows significant protection of hair cells over a broad range of neomycin concentrations, from 25 μM to 400 μM.
Adozelesin is an experimental antitumor drug of the duocarmycin class. It is the first of a class of DNA-sequence-selective alkylating agents. It binds to and a...
Glibenclamide potassium salt
Glibenclamide potassium salt is a salt form of Glibenclamide, a KATP channel blocker used for the treatment of type 2 diabetes. Glibenclamide binds to and inhib...
Sorbitol is a sugar alcohol and a sugar substitute.
Balsalazide is an anti-inflammatory drug used in the treatment of Inflammatory Bowel Disease. It is a new 5-aminosalicylic acid (5-ASA) containing prodrug. It i...
EN460 is a small molecule inhibitor by EN460 binding to ERO1α to promote the loss of flavin adenine dinucleotide (FAD) from the holoenzyme(IC50=1.9 uM) .
Albiflorin and Oxypaeoniflorin in rat plasma and was successfully applied to pharmacokinetic study.
Nicotinamide, a water-soluble vitamin, is an active component of coenzymes NAD and NADP, and also act as an activator of sirtuins.
ELN 484228 is an α-Synuclein blocker with activity in cellular models of α-synuclein-mediated dysfunction such as Parkinson’s Disease. Study showed that ELN4842...
Sipeimine, a natural product isolated from Fritillaria ussuriensis., can make Kaba cholinergic induced contraction of tracheal strips of the dose-response curve...
EL102, a HIF1α inhibitor, has been found to have potential effect in restraining polymerisation of tubulin and influencing the stability of microtubule. IC50: 2...