|Description||ESI-09 is a specific exchange protein directly activated by cAMP (EPAC) inhibitor with IC50 of 3.2 μM and 1.4 μM for EPAC1 and EPAC2, respectively, >100-fold selectivity over PKA.ESI-09 is a novel noncyclic nucleotide EPAC antagonist that is capable of specifically blocking intracellular EPAC-mediated Rap1 activation and Akt phosphorylation, as well as EPAC-mediated insulin secretion in pancreatic β cells. EPAC1 plays an important role in pancreatic cancer cell migration and invasion, and thus represents a potential target for developing novel therapeutic strategies for pancreatic cancer.|
Schisandrin B(Wuweizisu-B) is a dibenzocyclooctadiene derivative isolated from Fructus Schisandrae, has been shown to produce antioxidant effect on rodent liver...
NVP-231 is a potent, specific, and reversible CerK inhibitor that competitively inhibits binding of ceramide to CerK. NVP-231 is active in the low nanomolar ran...
Pipazetate, as a cough suppressant, is a non-narcotic oral antitussive agent acting centrally on the medullary cough center.
Cefpirome Sulfate is a fourth generation cephalosporin antibiotic. It was developed by German company Hoechst and France Roussel company together.
Bavachalcone inhibited osteoclast formation from precursor cells with the IC(50) of approximately 1.5 microg ml(-1). The activation of MEK, ERK, and Akt by rece...
Bialomicol is a synthetic bio-active chemical.
MK-0493 is a novel, potent, and selective agonist of MC4R( melanocortin receptor 4) , which is one of the best-validated genetic targets and considered one of t...
Gemilukast disodium salt
4'-Hydroxyphenyl carvedilol, as a metabolite of Carvedilol it is a nonselective beta blocker/alpha-1 blocker.
PLP(139-151), a synthetic myelin proteolipid protein (PLP) fragment, induces experimental autoimmune encephalomyelitis (EAE).
MCHr1 antagonist 1
A selective antagonist of melanin concentrating hormone-1 (MCH1) receptor
PF-1355 is a selective, mechanism-based inhibitor of myeloperoxidase (MPO) (IC50 = 1.5 μM in LPS-stimulated human whole blood) with excellent selectivity for MP...
3,3,5-Triiodo-L-thyronine(T3), an active metabolite of Thyroxine, could be effective in agonizing both thyroid hormone receptors TRα and TRβ so that might help ...
BPH-652, also known as BMS-187745, has been found to be a SQS inhibitor that could probably be effective against S. aureus infections.
CGP 71683 hydrochloride
CGP 71683 hydrochloride is a highly selective non-peptide antagonist of the NPY Y(5) receptor (IC50= 1.4 nM) with > 1000-fold selectivity over Y1 (IC50= 2765 nM...
Kaempferide is an O-methylated flavonol. It can be found in Kaempferia galanga (aromatic ginger). The enzyme kaempferol 4'-O-methyltransferase uses S-adenosyl-L...
Hydrocarbon chain derivative 1
Hydrocarbon chain derivative 1 shows inhibitory effect on lipid synthesis (IC50= 11 μM).
Ocaphane is a strong antitumor agent used on a number of animal tumors along with fairly toxic to hemopoietic organs.
Fenofibric acid is a lipid regulating agent available as delayed release capsules for oral administration.
Aluminum phthalocyanine tetrasulfonate t
Aluminum phthalocyanine disulfonate is a mixture of regional isomers, in which sulfonate group can be in 3- or 4- position of phenyl ring. It is a potent photos...