|Description||ESI-09 is a specific exchange protein directly activated by cAMP (EPAC) inhibitor with IC50 of 3.2 μM and 1.4 μM for EPAC1 and EPAC2, respectively, >100-fold selectivity over PKA.ESI-09 is a novel noncyclic nucleotide EPAC antagonist that is capable of specifically blocking intracellular EPAC-mediated Rap1 activation and Akt phosphorylation, as well as EPAC-mediated insulin secretion in pancreatic β cells. EPAC1 plays an important role in pancreatic cancer cell migration and invasion, and thus represents a potential target for developing novel therapeutic strategies for pancreatic cancer.|
Benzoylpaeoniflorin was found to be active against cyclooxygenase-1 and cyclooxygenase-2 enzymes.
PMX 464, a thiol-reactive quinol and putative thioredoxin inhibitor, is a putative inhibitor of the thioredoxin-thioredoxin reductase (Trx-TrxR) system, which s...
FCE 26644, also known as PNU-145156E, has been found to be a angiogenesis inhibitor that could have probable effect against solid tumours. It has already been d...
all cis-5,8,11,14,17-Eicosapentaenoic Ac
all cis-5,8,11,14,17-Eicosapentaenoic Acid Ethyl Ester is an omega-3 fatty acid agent. It is important polyunsaturated fatty acid of the marine food chain. It s...
CFI-400936 is a selective proteine kinase TTK inhibitor with IC50 value of 3.6nM. It demonstrates good activity in cell based assay and selectivity against a pa...
HIF-2a Translation Inhibitor 76
A cell-permeable HIF-2a translation inhibitor (IC50 value 5 µM). It inhibits HIF-2a translation via enhancing the binding of IRP1 (Iron-Regulatory Protein 1) to...
Schisanhenol, isolated from Schisandra rubriflora, has antioxidative effect on human LDL oxidation. The mechanism of Schisanhenol against LDL oxidation may be t...
ACV 1 has been found to be a neuronal nicotinic receptor antagonist and could probably alleviate neuropathic pain.
Levobunolol is a nonselective beta-adrenoceptor antagonist used in the treatment of glaucoma.
Eliglustat is a glucosylceramide synthase inhibitor indicated for the long-term treatment of type 1 Gaucher disease in patients who are CYP2D6 extensive metabol...
Clortermine hydrochloride is a new non-amphetamine anorexigenic agent. It is used as an anti-obesity drug.
CGP-62198A, a piperidine derivative, could probably be useful in some biological studies.
GI 254023X is a selective ADAM10 metalloprotease inhibitor with over 100-fold higher potency at ADAM10 than ADAM17. GI 254023X inhibits the proliferation of H92...
Docusate Sodium is a laxative used to treat constipation by absorbing into the bloodstream and excreted via the gallbladder after undergoing extensive metabolis...
DM4, a chemical derivative of maytansine, is an intermediate used to prepare semisynthetic maytansine analogs which can be conjugated with antibodies for the ta...
187-1, N-WASP inhibitor
187-1, N-WASP inhibitor can inhibit neural Wiskott-Aldrich syndrome protein by stabilizing the autoinhibited state of the protein. It can also block phosphatidy...
OMDM-2 is a selective inhibitor of anandamide cellular uptake. It can inhibit the cellular uptake of tritiated AEA with IC50 value of 3 µM,
A metabolite of Gleevec, a tyrosine kinase inhibitor.
ST-193 hydrochloride is the hydrochloride salt of ST-193 which is a potent, broad-spectrum small-molecule inhibitor of arenavirus entry and exhibits submicromol...