Esculetin - CAS 305-01-1
Catalog number: B0005-464319
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C9H6O4
Molecular Weight:
178.14
COA:
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Chemical Family:
Coumarins
Description:
Esculetin isolated from the peel of Aesculus hippocastanum L. It can quench the inner fluorescence of bovine serum albumin.
Ordering Information
Catalog Number Size Price Stock Quantity
B0005-464319 10 g $199 In stock
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Purity:
0.985
Appearance:
Powder
Synonyms:
6,7-DIHYDROXY-CHROMEN-2-ONE
MSDS:
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Application:
anticoagulant effect; antifungal; antiinflammatory;
Quality Standard:
Enterprise Standard
Quantity:
Grams-Kilograms
Density:
1.6±0.1 g/cm3
1.Studies on the hepatocyte protective activity and the structure-activity relationships of quinic acid and caffeic acid derivatives from the flower buds of Lonicera bournei.
Xiang T;Xiong QB;Ketut AI;Tezuka Y;Nagaoka T;Wu LJ;Kadota S Planta Med. 2001 Jun;67(4):322-5.
13 quinic acid derivatives along with caffeic acid, methyl caffeate, myo-inositol, bis[5-formylfurfuryl] ether and 6,7-dihydroxycoumarin were isolated from the ethanol extract of the flower buds of Lonicera bournei Hemsl., among which 8 compounds were firstly obtained from this genus. The effects of different solvent soluble fractions of the ethanol extract and the pure compounds on heptocyte death induced by D-galactosamine (D-GalN)/tumor necrosis factor alpha (TNF-alpha) were studied, and the structure-activity relationships were also discussed.
2.An Overview of Chemical Profiles, Antioxidant and Antimicrobial Activities of Commercial Vegetable Edible Oils Marketed in Japan.
Xuan TD;Gangqiang G;Minh TN;Quy TN;Khanh TD Foods. 2018 Feb 10;7(2). pii: E21. doi: 10.3390/foods7020021.
This study analyzed chemical components and investigated the antioxidant and antimicrobial activities of fourteen vegetable edible oils marketed in Japan. High-performance liquid chromatography (HPLC) was used to identify and quantify principal phenolic acids and flavonoids. In the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay, sunflower, safflower, canola, soybean, Inca inchi, sesame, and rice bran showed markedly greater activity, whilst the percentage of lipid peroxidation inhibition (LPI%) in sunflower, canola, cotton, grape, flax, perilla, Inca inchi, perillartine, and rice bran were significantly higher than other oils. Maximum total phenol content (TPC) was recorded in flax, followed by perillartine, rice bran, and perilla, whereas total flavonoid content (TFC) was the greatest in Inca inchi and sesame. Benzoic acid was the most common constituent, followed by vanillic acid, ;p;-hydroxybenzoic acid, ferulic acid, and ;p;-coumaric acid. On the other hand, luteolin was the most abundant flavonoid, followed by esculetin, myricetin, isoquercetin, and kaempferol, while fisetin was detected only in sunflower. In general, all of the edible oils showed antimicrobial activity, but the growth inhibition of ;Staphylococcus aureus; and ;Escherichia coli; of cotton, grape, chia, sesame, and rice bran were greater than other oils.
3.Separation and determination of coumarins including furanocoumarins using micellar electrokinetic capillary chromatography.
Dresler S;Bogucka-Kocka A;Kováčik J;Kubrak T;Strzemski M;Wójciak-Kosior M;Rysiak A;Sowa I Talanta. 2018 Sep 1;187:120-124. doi: 10.1016/j.talanta.2018.05.024. Epub 2018 May 8.
The conditions of micellar electrokinetic capillary chromatography for separation and simultaneous measurement of coumarins (coumarin, scoparone, isoscopoletin, esculin, esculetin, umbelliferone) including furanocoumarins (xanthotoxin, byakangelicin, isopimpinellin, bergapten, phellopterin, xanthotoxol) have been elaborated. The influence of different parameters, such as the pH of the buffer, sodium cholate (SC) or methanol concentration in the buffer, on the migration time, peak resolution, peak asymmetry, and number of theoretical plates was investigated. The optimum separation of the compounds was achieved using 50-µm i.d. capillaries with a total length of 64.5 cm (56 cm effective length) and a buffer system at pH 9.00 consisting of 50 mM sodium tetraborate, 45 mM SC, and 20% of methanol (v/v). The developed method ensured good repeatability of corrected peak areas and migration times (the relative standard deviations were in the range of 2.8-6.1% and 0.8-4.0%, respectively). The average limit of detection for all studied compounds was below 1.3 µg mL. Moreover, good linearity of the relationship between the peak corrected area and the concentration of the compounds was observed (correlation coefficient >0.
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CAS 305-01-1 Esculetin

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