erythro-Guaiacylglycerol - CAS 38916-91-5
Catalog number: 38916-91-5
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erythro-Guaiacylglycerol isolated from the barks of Eucommia ulmoides Oliver.
> 95%
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1.Promotion of mammalian angiogenesis by neolignans derived from soybean extracellular fluids.
Kordbacheh F;Carruthers TJ;Bezos A;Oakes M;Du Fall L;Hocart CH;Parish CR;Djordjevic MA PLoS One. 2018 May 8;13(5):e0196843. doi: 10.1371/journal.pone.0196843. eCollection 2018.
Excessive or insufficient angiogenesis is associated with major classes of chronic disease. Although less studied, small molecules which can promote angiogenesis are being sought as potential therapeutics for cardiovascular and peripheral arterial disease and stroke. Here we describe a bioassay-directed discovery approach utilising size exclusion and liquid chromatography to purify components of soybean xylem sap that have pro-angiogenic activity. Using high resolution accurate mass spectrometry and nuclear magnetic resonance spectroscopy, the structure of two pro-angiogenic molecules (FK1 and FK2) were identified as erythro-guaiacylglycerol-8-O-4'-(coniferyl alcohol) ether (eGGCE), and threo-guaiacylglycerol-8-O-4'-(coniferyl alcohol) ether (tGGCE). These two molecules, which are coniferyl neolignan stereoisomers, promoted in vitro angiogenesis in the μM to nM range. Independently sourced samples of eGGCE and tGGCE exhibited comparable pro-angiogenic activity to the soybean derived molecules. The cellular mode of action of these molecules was investigated by studying their effect on endothelial cell proliferation, migration, tube formation and adhesion to the extracellular matrix (ECM) components, fibronectin and vitronectin.
2.[Lignans from stems of Sambucus williamsii].
Ouyang F;Liu Y;Xiao H;Yu H;Wang N;Yao X Zhongguo Zhong Yao Za Zhi. 2009 May;34(10):1225-7.
OBJECTIVE: ;To study the chemical constitutents of the 60% ethanol extract of the stems of Sambucus williamsii.;METHOD: ;Compounds were isolated and purified by Diaion D101, silica gel,Sephadex LH-20, ODS column chromatography and preparative HPLC. Their structures were identified by spectroscopic methods.;RESULT: ;Seven lignans were isolated and identified as erythro-guaiacylglycerol-beta-O-4'-sinapyl ether (1), 1-( 4'-hydroxy-3'-methoxyphenyl) -2- [4"-( 3-hydroxypropyl) -2", 6"-dimethoxyphenoxy] propane-1,3-diol (2), isolariciresinol (3), burselignan (4), lyoniresinol (5), 5-methoxy-isolariciresinol (6), cycloolivil (7).;CONCLUSION: ;All these compounds were obtained from this genus for the first time.
3.[Chemical constituents from stems of Aquilaria sinensis].
Li W;Mei WL;Wang H;Zuo WJ;Yang DL;Dai HF Zhongguo Zhong Yao Za Zhi. 2013 Sep;38(17):2826-31.
OBJECTIVE: ;To study the constituents from the stems of Aquilaria sinensis.;METHOD: ;The chemical constituents were isolated by various column chromatographic methods. The structures were identified by spectral analysis including NMR and MS data.;RESULT: ;Sixteen compounds were isolated and identified as threo-buddlenol C (1), thero-ficusesquilignan A (2), erythro-buddlenol C (3), (+/-) buddlenol D (4), (-) medioresinol (5), (-) pinoresinol (6), 5'-methoxy lariciresinol (7), erythro-guaiacylglycerol-beta-coniferyl ether (8), thero-guaiacylglycerol-beta-coniferyl ether (9), herpetin (10), (+) syringaresinol (11), curuilignan (12), ciwujiatone (13), coniferyl alcohol (14), 3, 4, 5-trimethoxyphenol (15) and cucurbitacin (16).;CONCLUSION: ;All the compounds, except for 11-13 were obtained from A. sinensis for the first time.
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CAS 38916-91-5 erythro-Guaiacylglycerol

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