Erdosteine - CAS 84611-23-4
Catalog number: 84611-23-4
Category: Inhibitor
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Molecular Formula:
Molecular Weight:
Erdosteine is a mucolytic which is used in treatment of excessive viscous mucus.
Erdosteine; PV 144; PV144; PV-144; RV 144; RV144; RV-144
Canonical SMILES:
1.Antioxidant effect of erdosteine and lipoic acid in ovarian ischemia-reperfusion injury.
Dokuyucu R1, Karateke A2, Gokce H3, Kurt RK4, Ozcan O5, Ozturk S5, Tas ZA3, Karateke F6, Duru M7. Eur J Obstet Gynecol Reprod Biol. 2014 Dec;183:23-7. doi: 10.1016/j.ejogrb.2014.10.018. Epub 2014 Oct 24.
OBJECTIVE: To investigate the effects of erdosteine and alpha lipoic acid (ALA) in a rat model of ovarian ischaemia-reperfusion injury.
2.Protective effects of erdosteine against nephrotoxicity caused by gamma radiation in male albino rats.
Elkady AA1, Ibrahim IM2. Hum Exp Toxicol. 2016 Jan;35(1):21-8. doi: 10.1177/0960327115574919. Epub 2015 Feb 24.
The aim of this study was focused on investigating the possible protective effect of erdosteine against gamma radiation-induced renal lesions in male albino rats. Twenty-eight albino rats were divided into four equal groups as follows: control group, irradiated group (animals subjected to whole-body gamma irradiation at a dose of 5 Gy), treated group (each rat received 100 mg/kg body weight once daily, orally by gastric tube, erdosteine for 1 week), and treated irradiated group (each rat received 100 mg/kg body weight once daily, orally by gastric tube, erdosteine for 1 week, then exposed to whole-body gamma irradiation at a dose of 5 Gy). The results revealed that the administration of erdosteine to rats before irradiation significantly ameliorated the changes occurred in kidney function (creatinine and urea) compared with irradiated group. Also the changes in serum tumor necrosis factor α, interleukin 1β, and interleukin 6 activities were markedly improved compared with the corresponding values of irradiated group.
3.Investigation of the protective effect of erdosteine against cyclosporine-induced injury in rat liver with histological and biochemical methods.
Nacar A, Karaboğa I, Okuyan HM, Sefil NK, Nacar E, Motor S, Akküçük S, Ozkan OV. Turk J Med Sci. 2015;45(6):1390-5.
BACKGROUND/AIM: In the present study, the protective effect of erdosteine against cyclosporine-induced injury in rat liver was investigated with histological and biochemical methods.
4.Erdosteine protects HEI-OC1 auditory cells from cisplatin toxicity through suppression of inflammatory cytokines and induction of Nrf2 target proteins.
Kim SJ1, Park C2, Lee JN1, Lim H3, Hong GY3, Moon SK2, Lim DJ2, Choe SK4, Park R5. Toxicol Appl Pharmacol. 2015 Oct 15;288(2):192-202. doi: 10.1016/j.taap.2015.07.014. Epub 2015 Jul 18.
Cisplatin has many adverse effects, which are a major limitation to its use, including ototoxicity, neurotoxicity, and nephrotoxicity. This study aims to elucidate the protective mechanisms of erdosteine against cisplatin in HEI-OC1 cells. Pretreatment with erdosteine protects HEI-OC1 cells from cisplatin-medicated apoptosis, which is characterized by increase in nuclear fragmentation, DNA laddering, sub-G0/G1 phase, H2AX phosphorylation, PARP cleavage, and caspase-3 activity. Erdosteine significantly suppressed the production of reactive nitrogen/oxygen species and pro-inflammatory cytokines such as tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 in cisplatin-treated cells. Studies using pharmacologic inhibitors demonstrated that phosphatidylinositol-3-kinases (PI3K) and protein kinase B (Akt) have protective roles in the action of erdosteine against cisplatin in HEI-OC1 cells. In addition, pretreatment with erdosteine clearly suppressed the phosphorylation of p53 (Ser15) and expression of p53-upregulated modulator of apoptosis.
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CAS 84611-23-4 Erdosteine

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