Ercalcidiol - CAS 21343-40-8
Catalog number: 21343-40-8
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C28H44O2
Molecular Weight:
412.65
COA:
Inquire
Targets:
VD/VDR
Description:
A metabolite of Vitamin D2
Purity:
>98%
Synonyms:
25-hydroxy Vitamin D2
MSDS:
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InChIKey:
KJKIIUAXZGLUND-ICCVIKJNSA-N
InChI:
InChI=1S/C28H44O2/c1-19-10-14-24(29)18-23(19)13-12-22-8-7-17-28(6)25(15-16-26(22)28)20(2)9-11-21(3)27(4,5)30/h9,11-13,20-21,24-26,29-30H,1,7-8,10,14-18H2,2-6H3/b11-9+,22-12+,23-13-/t20-,21+,24+,25-,26+,28-/m1/s1
Canonical SMILES:
CC(C=CC(C)C(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CCC3=C)O)C
1.Relation of serum 25-hydroxyvitamin D status with skeletal muscle mass by sex and age group among Korean adults.
Ko MJ1, Yun S2, Oh K2, Kim K3. Br J Nutr. 2015 Dec 14;114(11):1838-44. doi: 10.1017/S0007114515003633. Epub 2015 Sep 30.
The objective of this study was to examine whether high serum 25-hydroxyvitamin D (25(OH)D) concentration was associated with high skeletal muscle mass, taking into account the effects of sex and age among the participants of the Korea National Health and Nutrition Examination Survey (KNHANES) aged 40 years or older. This was a cross-sectional study using data from the 2009 to 2010 KNHANES; a total of 8406 subjects (3671 men and 4735 women) were included. The appendicular skeletal muscle mass index (ASMMI, kg/m2) was estimated to measure the skeletal muscle mass. Hypovitaminosis was classified when the level of serum 25(OH)D was <20 ng/ml. The general linear model adjusted for confounding factors was used to determine differences in means of ASMMI by 25(OH)D status. The mean values of ASMMI were higher for men when compared with women. Women had a greater proportion of hypovitaminosis (71·1%) compared with men (53·2%). After adjusting for multiple factors, men were seen to have significant differences in ASMMI based on 25(OH)D status regardless of age, showing a lower mean value of ASSMI in those with hypovitaminosis.
2.No increase in risk of hip fracture at high serum retinol concentrations in community-dwelling older Norwegians: the Norwegian Epidemiologic Osteoporosis Studies.
Holvik K1, Ahmed LA2, Forsmo S3, Gjesdal CG4, Grimnes G5, Samuelsen SO6, Schei B7, Blomhoff R8, Tell GS9, Meyer HE10. Am J Clin Nutr. 2015 Nov;102(5):1289-96. doi: 10.3945/ajcn.115.110528. Epub 2015 Sep 16.
BACKGROUND: Norway has the highest hip fracture rates worldwide and a relatively high vitamin A intake. Increased fracture risk at high intakes and serum concentrations of retinol (s-retinol) have been observed in epidemiologic studies.
3.Standardizing 25-hydroxyvitamin D values from the Canadian Health Measures Survey.
Sarafin K1, Durazo-Arvizu R2, Tian L3, Phinney KW4, Tai S5, Camara JE5, Merkel J6, Green E7, Sempos CT6, Brooks SP8. Am J Clin Nutr. 2015 Nov;102(5):1044-50. doi: 10.3945/ajcn.114.103689. Epub 2015 Sep 30.
BACKGROUND: The Canadian Health Measures Survey (CHMS) is an ongoing cross-sectional national survey that includes a measure of 25-hydroxyvitamin D [25(OH)D] by immunoassay. For cycles 1 and 2, the collection period occurred approximately every 2 y, with a new sample of ∼5600 individuals.
4.Calcium-Vitamin D Co-supplementation Affects Metabolic Profiles, but not Pregnancy Outcomes, in Healthy Pregnant Women.
Asemi Z1, Samimi M2, Siavashani MA3, Mazloomi M4, Tabassi Z2, Karamali M4, Jamilian M5, Esmaillzadeh A6. Int J Prev Med. 2016 Mar 1;7:49. doi: 10.4103/2008-7802.177895. eCollection 2016.
BACKGROUND: Pregnancy is associated with unfavorable metabolic profile, which might in turn result in adverse pregnancy outcomes. The current study was designed to evaluate the effects of calcium plus Vitamin D administration on metabolic status and pregnancy outcomes in healthy pregnant women.
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