ERB-041 - CAS 524684-52-4
Catalog number: 524684-52-4
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C15H10FNO3
Molecular Weight:
271.24
COA:
Inquire
Targets:
Estrogen Receptor/ERR
Description:
ERB 041 is a highly selective agonist of the ERβ subtype of the estrogen receptor, displays >200-fold selectivity for ERβ over Erα.
Publictions citing BOC Sciences Products
  • >> More
Purity:
≥98%
Appearance:
Off-White to Pale Yellow Solid
Synonyms:
Prinaberel; 2-(3-Fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol; WAY-202041; (4Z)-4-(7-ethenyl-5-hydroxy-3H-1,3-benzoxazol-2-ylidene)-2-fluorocyclohexa-2,5-dien-1-one
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
Potent ERβ agonist
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
Melting Point:
149-152°C
InChIKey:
FCXYSEXZEGPLGG-DHDCSXOGSA-N
InChI:
1S/C15H10FNO3/c1-2-8-5-10(18)7-12-14(8)20-15(17-12)9-3-4-13(19)11(16)6-9/h2-7,17-18H,1H2/b15-9-
Canonical SMILES:
C=CC1=CC(=CC2=C1OC(=C3C=CC(=O)C(=C3)F)N2)O
Current Developer:
Wyeth
1.Efficacy and safety of a selective estrogen receptor β agonist, ERB-041, in patients with rheumatoid arthritis: a 12-week, randomized, placebo-controlled, phase II study.
Roman-Blas JA1, Castañeda S, Cutolo M, Herrero-Beaumont G. Arthritis Care Res (Hoboken). 2010 Nov;62(11):1588-93. doi: 10.1002/acr.20275. Epub 2010 Jun 15.
OBJECTIVE: Selective estrogen receptor β (ERβ) agonists have demonstrated relevant antiinflammatory effects in different animal models. This study aimed to compare the efficacy and safety of one of these agonists, ERB-041, in subjects with rheumatoid arthritis (RA).
2.Erb-041, an estrogen receptor-β agonist, inhibits skin photocarcinogenesis in SKH-1 hairless mice by downregulating the WNT signaling pathway.
Chaudhary SC1, Singh T, Talwelkar SS, Srivastava RK, Arumugam A, Weng Z, Elmets CA, Afaq F, Kopelovich L, Athar M. Cancer Prev Res (Phila). 2014 Feb;7(2):186-98. doi: 10.1158/1940-6207.CAPR-13-0276. Epub 2013 Nov 11.
Estrogen receptors (ER), including ER-α and ER-β, are known to regulate multiple biologic responses in various cell types. The expression of ER-β is lost in various cancers. ER-β agonists were shown to modulate inflammation, cancer cell proliferation, and differentiation. Here, we investigated the cancer chemopreventive properties of Erb-041, an ER-β agonist, using a model of UVB-induced photocarcinogenesis in SKH-1 mice. Erb-041 significantly reduced UVB-induced carcinogenesis. Tumor numbers and volume were reduced by 60% and 84%, respectively, in the Erb-041-treated group as compared with UVB (alone) control. This inhibition in tumorigenesis was accompanied by the decrease in proliferating cell nuclear antigen (PCNA), cyclin D1, VEGF, and CD31, and an increase in apoptosis. The lost ER-β expression in squamous cell carcinomas (SCC) was significantly recovered by Erb-041 treatment. In addition, the UVB-induced inflammatory responses were remarkably reduced.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Estrogen Receptor/ERR Products


CAS 529-59-9 Genistin

Genistin
(CAS: 529-59-9)

Genistin is a derivative of Genistein, which is a PTK inhibitor. Genistin acts as a selective estrogen receptor modulator (SERM). It increases growth of breast ...

CAS 53-16-7 Estrone

Estrone
(CAS: 53-16-7)

Estrone is one of the three naturally occurring estrogens, the others being estradiol and estriol. Estrone is synthesized from androstenedione by the aromatase ...

CAS 82640-04-8 Raloxifene HCl

Raloxifene HCl
(CAS: 82640-04-8)

Raloxifene is an oral selective estrogen receptor modulator (SERM) that has estrogenic actions on bone and anti-estrogenic actions on the uterus and breast. It ...

CAS 50-50-0 Estradiol Benzoate

Estradiol Benzoate
(CAS: 50-50-0)

Estradiol benzoate is an estradiol analog which binds to the human, murine and chicken ERα with IC50 of 22-28 nM.

CAS 54965-24-1 Tamoxifen Citrate

Tamoxifen Citrate
(CAS: 54965-24-1)

Tamoxifen Citrate is an antagonist of the estrogen receptor by competitive inhibition of estrogen binding, leading to a reduction in DNA synthesis and cellular ...

CAS 57-63-6 Ethinyl Estradiol

Ethinyl Estradiol
(CAS: 57-63-6)

Ethinyl Estradiol is a derivative of 17β-estradiol (E2), the major endogenous estrogen in humans. EE2 is an orally bioactive estrogen used in many formulations ...

CAS 1853279-29-4 ZB716

ZB716
(CAS: 1853279-29-4)

ZB716 is a steroidal and orally bioactive selective estrogen receptor downregulator (SERD) with antiestrogenic activity. In both tamoxifen-naive and tamoxifen-r...

BHPI
(CAS: 56632-39-4)

BHPI is an antagonist of estrogen receptor α (ERα), for it elicits sustained ERα-dependent activation of the endoplasmic reticulum (EnR) stress sensor.

CAS 7280-37-7 Estropipate

Estropipate
(CAS: 7280-37-7)

Estropipate is an estrogen receptor agonist used in post-menopausal women for hormonal replacement therapy, with benefits to improved cognition and prevention o...

CAS 1197194-41-4 Endoxifen hydrochloride

Endoxifen hydrochloride
(CAS: 1197194-41-4)

Endoxifen hydrochloride is a metabolite of Tamoxifen and a selective estrogen receptor modulator (SERM) that inhibits the growth of estrogen-stimulated BT474 ce...

CAS 50-41-9 Clomifene citrate

Clomifene citrate
(CAS: 50-41-9)

Clomifene Citrate is a selective estrogen receptor modulator used in the treatment of ovulation induction. It is used to treat breast cancer for its antineoplas...

CAS 1845-11-0 Nafoxidine

Nafoxidine
(CAS: 1845-11-0)

Nafoxidine, a triphenylethylene nonsteroidal agent, is a partial estrogen antagonist.

CAS 112093-28-4 Endoxifen

Endoxifen
(CAS: 112093-28-4)

Endoxifen, a significant metamolite of Tamoxifen, is a regulator of estrogen receptor and could be effective in the treatment of estrogen-dependent breast cance...

CAS 198481-33-3 Bazedoxifene acetate

Bazedoxifene acetate
(CAS: 198481-33-3)

Bazedoxifene acetate, also called as TSE424 or WAY-140424, with antiosteoporotic it is a selective nonsteroidal estrogen receptor modulator (SERM) (ERα: IC50= 2...

CAS 7599-79-3 trans-Clomiphene Citrate

trans-Clomiphene Citrate
(CAS: 7599-79-3)

Enclomiphene citrateis a non-steroidal estrogen receptor antagonist. It can be used for secondary hypogonadism in overweight men wishing to restore normal testi...

CAS 524684-52-4 ERB-041

ERB-041
(CAS: 524684-52-4)

ERB 041 is a highly selective agonist of the ERβ subtype of the estrogen receptor, displays >200-fold selectivity for ERβ over Erα.

CHF-4227
(CAS: 444643-64-5)

CHF-4227 is a selective estrogen receptor modulator, binds with high affinity to the human estrogen receptor-alpha and -beta (dissociation constant K(i) = 0.017...

AZD9496
(CAS: 1639042-08-2)

AZD9496 is a potent and orally bioavailable selective estrogen receptor downregulator and antagonist. AZD9496 can induce ERα degradation in breast cancer cell l...

CAS 77599-17-8 Panomifene

Panomifene
(CAS: 77599-17-8)

Panomifene is an Estrogen receptor antagonist under the development of Egis Pharmaceuticals. Phase II clinical trials for the treatment of breast cancer was dis...

CAS 190791-29-8 Lasofoxifene tartrate

Lasofoxifene tartrate
(CAS: 190791-29-8)

Lasofoxifene tartrate is the tartrate salt form of Lasofoxifene. Lasofoxifene is a third-generation selective estrogen receptor modulators (SERMs).

Chemical Structure

CAS 524684-52-4 ERB-041

Quick Inquiry

Verification code

Featured Items