EPZ015866 - CAS 1616391-87-7
Catalog number:
1616391-87-7
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C22H28N4O2
Molecular Weight:
380.48
COA:
Inquire
Targets:
HMTase
Description:
EPZ015866,also called as GSK591, is a chemical probe for PRMT5 which has a role in diverse cellular processes including tumorigenesis. It exhibits excellent selectivity against a panel of methyltransferases. Inhibits the PRMT5/MEP50 complex from methylati
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Appearance:
Solid powder
Synonyms:
2-(cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]pyridine-4-carboxamide EPZ015866 GSK591 GTPL8954 SCHEMBL16220740 GSK3203591 2-(cyclobutylamino)-N-[(2S)-2-hydroxy-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]pyridine-4-carbo
Solubility:
DMSO,76 mg/mL (199.74 mM); Ethanol, 76 mg/mL (199.74 mM); Water, <1 mg/mL (<1 mM);
Storage:
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -28℃ for long term (months to years).
MSDS:
Inquire
Shelf Life:
2 years
Quantity:
Grams-Kilos
Boiling Point:
648.4±55.0 °C | Condition: Press: 760 Torr
Density:
1.252±0.06 g/cm3
InChIKey:
TWKYXZSXXXKKJU-FQEVSTJZSA-N
InChI:
1S/C22H28N4O2/c27-20(15-26-11-9-16-4-1-2-5-18(16)14-26)13-24-22(28)17-8-10-23-21(12-17)25-19-6-3-7-19/h1-2,4-5,8,10,12,19-20,27H,3,6-7,9,11,13-15H2,(H,23,25)(H,24,28)/t20-/m0/s1
Canonical SMILES:
C1CC(C1)NC2=NC=CC(=C2)C(=O)NCC(CN3CCC4=CC=CC=C4C3)O
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