|Description||EPZ015866，also called as GSK591, is a chemical probe for PRMT5 which has a role in diverse cellular processes including tumorigenesis. It exhibits excellent selectivity against a panel of methyltransferases. Inhibits the PRMT5/MEP50 complex from methylati|
|Synonyms||2-(cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]pyridine-4-carboxamide EPZ015866 GSK591 GTPL8954 SCHEMBL16220740 GSK3203591 2-(cyclobutylamino)-N-[(2S)-2-hydroxy-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]pyridine-4-carbo|
|Solubility||DMSO,76 mg/mL (199.74 mM); Ethanol, 76 mg/mL (199.74 mM); Water, <1 mg/mL (<1 mM);|
|Storage||Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -28℃ for long term (months to years).|
|Shelf Life||2 years|
|Boiling Point||648.4±55.0 °C | Condition: Press: 760 Torr|
Amodiaquin dihydrochloride dihydrate
Amodiaquine, a 4-aminoquinoquinoline compound, has is a histamine N-methyltransferase inhibitor, used as an antimalarial and anti-inflammatory agent been used a...
MI-3 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 648 nM.
BAY-598 R-isomer is the R-isomer of BAY589 which is a potent, peptide-competitive chemical probe for SET and MYND domain-containing protein 2 (SMYD2), IC50 valu...
UNC1215 is a potent, selective antagonist of L3MBTL3 with cellular activity. UNC1215 has an IC50 of 20 nM and > 100-fold selectivity over 13 HMTs and selected r...
MI-503 is a potent, selective and orally bioavailable Menin-MLL inhibitor (IC50= 14.7 nM). It is used in the pharmacological inhibition of menin-MLL interaction...
AZ505 is a potent and highly selective inhibitor of the oncogenic protein SMYD2(IC50=0.12 μM) with potential anticancer activity.
LLY-507, a lysine N-methyltransferase, is a cell-active, small molecule, and selective inhibitor of Protein-lysine Methyltransferase SMYD2 (IC50 = 15 nM), with ...
UNC0379 trifluoroacetate is a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8 with IC50 of 7.3±1.0 uM; selective over 15...
SGC2085, also called as GTPL9259, is a potent and selective Coactivator Associated Arginine Methyltransferase 1 (CARM1), which has an IC50 of 50 nM for CARM1 an...
A highly potent and selective EZH2 inhibitor (biochemical IC50=2 nM, cellular EC50=32 nM)
AZ505 ditrifluoroacetate is a potent and highly selective inhibitor of the oncogenic protein SMYD2(IC50=0.12 μM) with potential anticancer activity.
UNC0321 is the first G9a inhibitor with picomolar potency and the most potent G9a inhibitor to date. Protein lysine methyltransferase G9a, which catalyzes methy...
AMI-1 is a potent and specific Histone Methyltransferase (HMT) inhibitor with IC50 of 3.0 μM and 8.8 μM for yeast Hmt1p and human PRMT1, respectively.
BIX-01294, a diazepin-quinazolinamine derivative, is a selective inhibitor of G9a histone methyl transferase (G9a HMTase) that impairs G9a HMTase and generation...
EPZ-5676 is a small molecule inhibitor of histone methyltransferase with potential antineoplastic activity. Upon intravenous administration, EPZ-5676 specifical...
UNC-0646 is a novel G9a inhibitor with excellent potency in a variety of cell lines and excellent separation of functional potency versus cell toxicity.
C7280948 is a novel PRMT1 inhibitor ( IC50=12.75 μM).
BCI-121, a SMYD3 inhibitor, induces a significant reduction in SMYD3 activity both in vitro and in CRC cells.
UNC0379 is a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8. UNC0379 is active in multiple biochemical assays. Its affinity t...