Epothilone B - CAS 152044-54-7
Catalog number:
152044-54-7
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C27H41NO6S
Molecular Weight:
507.68
COA:
Inquire
Targets:
Microtubule/Tubulin
Description:
Epothilone B, also called Patupilone, is a microtubule stabilization agent (EC0.01= 1.8 μM). It induces mitotic arrest at the G2-M transition in Hs578T (IC50 = 3nM) and HeLa cells (IC50 = 32nM).
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Brife Description:
A microtubule stabilization agent (EC0.01= 1.8 μM)
Appearance:
White solid
Synonyms:
Epothilone B; Patupilone; 152044-54-7; (-)-Epothilone B; EpoB; EPO906; Epo B; EPO 906; UEC0H0URSE; UNII-UEC0H0URSE
Solubility:
Soluble to 10 mM in DMSO
Storage:
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -58℃ for long term (months to years).
MSDS:
Inquire
Boiling Point:
680.188ºC at 760 mmHg
Density:
1.137 g/cm3
InChIKey:
QXRSDHAAWVKZLJ-PVYNADRNSA-N
InChI:
1S/C27H41NO6S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)33-23(30)13-21(29)26(5,6)25(32)17(3)24(15)31/h11,14-15,17,20-22,24,29,31H,8-10,12-13H2,1-7H3/b16-11+/t15-,17+,20-,21-,22-,24-,27+/m0/s1
Canonical SMILES:
CC1CCCC2(C(O2)CC(OC(=O)CC(C(C(=O)C(C1O)C)(C)C)O)C(=CC3=CSC(=N3)C)C)C
1. Radiosensitizing effect of epothilone B on human epithelial cancer cells
T.Baumgart, G.Klautke, S.Kriesen, S.A.Kuznetsov. Strahlenther Onkol 2012 • 188:177–184
Epothilone B induced a concentration- and application-dependent antiproliferative effect on the cells, with IC50 values in the low nanomolar range. Colony forming assays showed a synergistic radiosensitive effect on both cell lines which was dependent on incubation time and applied concentration of epothilone B. The γH2AX assays demonstrated that ionizing radiation combined with the drug resulted in a concentration-dependent increase in the number of double-strand breaks and suggested a reduction in DNA repair capacity. Epothilone B produced enhanced microtubule bundling and abnormal spindle formation as revealed by immunofluo-rescence microscopy and caused microtubule formation from purified tubulin.
2. A Ph-responsive High Density Lipoprotein-like Nanoparticle of Epothilone B
Ji-Chun Lee, Byoung-Jae Kong, Jae Yoon Shin. Biotechnology and Bioprocess Engineering 20: 249-258 (2015
Therefore, various pH-responsive drug delivery systems have been designed to release enclosed drugs at the target site before lysosomal degradation occurs. Recently, we have shown that rHDL can be composed to release paclitaxel (PTX) in a pH-responsive manner. Perhaps because endosomal escape of the PTX was facilitated, the pH-responsive PTX-rHDL was more potent than normal PTX-rHDL. Inspired by this success, we determined to assemble the pH-responsive rHDL of epothilone B (EpoB), which is extremely more potent than PTX. epothilone B (EpoB) is a member of the epothilone class, which is a group of microtubule-stabilizing agents. epothilone B (EpoB) binds to β-tubulin subunits of microtubules with higher affinity than other taxanes. Most cancer cells overexpressing human epidermal growth factor receptor 2 (HER2) are resistant to taxane chemotherapy.
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CAS 152044-54-7 Epothilone B

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