|Description||Epinastine is a second-generation antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis. It is highly selective for the H1 receptor and does not cross the blood-brain-barrier. It shows a high affinity to H1-receptors in receptor binding studies in the guinea pig ileum. It inhibits histamine-induced reactions in the skin or the lung of rats, dogs and guinea pigs. It is able to displace specific [3H]NC-5Z binding at low concentrations in the locust nervous tissue. It antagonises octopamine-induced cAMP formation in the insect brain. It is effective in inhibiting not only Ca2+ uptake into lung mast cells in actively sensitized guinea pigs but also Ca2+ release from the intracellular Ca store of rat peritoneal mast cells exposed to both compound 48/80 and substance. It is produced by Allergan and marketed by Inspire in the United States.|
|Appearance||White to yellow crystalline powder|
|Synonyms||9,13b-Dihydro-1H-dibenz[c,f]imidazo[1,5-a]azepin-3- amine;3-Amino-9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepine;Apinastine Base;WAL 801|
|Solubility||DMSO 57 mg/mL; Water 57 mg/mL|
|Application||Epinastine is used in eye drops to treat allergic conjunctivitis. It is highly selective for the H1 receptor and does not cross the blood-brain-barrier.|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Quantity||Grams to Kilograms|
|Boiling Point||428.0±55.0 °C | Condition: Press: 760 Torr|
|Melting Point||205-208 °C|
|Density||1.32±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr|
|Current Developer||Epinastine is produced by Allergan and marketed by Inspire in the United States.|
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