(-)-Epigallocatechin - CAS 970-74-1
Catalog number: 970-74-1
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
(-)-Epigallocatechin is the most abundant flavonoid in green tea. It is a major green tea polyphenol with antioxidant, anti-inflammatory, and anticancer activities. It can bind to unfolded native polypeptides and prevent conversion to amyloid fibrils. It is a potent inhibitor of amyloidogenic cystatin I66Q amyloid fibril formation in vitro. It prevents amyloidogenic cystatin fibril formation by stabilizing the molecule in its native-like state as opposed to redirecting aggregation to disordered, amorphous aggregates. It induced the formation of hydroxyl radicals in E. faecalis. It has been shown to scavenge DPPH radicals and prevent the growth of several different AML cell lines at micromolar concentrations.
Publictions citing BOC Sciences Products
  • >> More
EGC; Epigallocatechin; l-Epigallocatechin; epi-Gallocatechin
1.A-type dimeric epigallocatechin-3-gallate (EGCG) is a more potent inhibitor against the formation of insulin amyloid fibril than EGCG monomer.
Nie RZ1, Zhu W1, Peng JM1, Ge ZZ1, Li CM2. Biochimie. 2016 Apr 12. pii: S0300-9084(16)30038-4. doi: 10.1016/j.biochi.2016.03.011. [Epub ahead of print]
Because fibrillary protein aggregates is regarded to be closely associated with many diseases such as Alzheimer's disease, diabetes, and Parkinson's disease, growing interest and researches have been focused on finding potential fibrillation inhibitors. In the present study, the inhibitory effects of epigallocatechin-3-gallate (EGCG) and A-type dimeric epigallocatechin-3-gallate (A-type EGCG dimer) on the formation of insulin fibrillation were compared by multi-dimensional approaches including thioflavin-T (ThT) fluorescence assay, 1-anilinonaphthalene-8-sulfonic (ANS) fluorescence assay, dynamic light scattering (DLS), transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectroscopy and circular dichroism (CD) spectroscopy. Our results confirmed that A-type EGCG dimer is a more potent inhibitor against the formation of bovine insulin amyloid fibril than EGCG. In addition, A-type EGCG dimer could not only inhibit insulin amyloid fibril formation, but also change the aggregation pathway and induce bovine insulin into amorphous aggregates.
2.Hypolipidemic effects of flavonoids extracted from Lomatogonium rotatum.
Bao L1, Hu L2, Zhang Y3, Wang YI1. Exp Ther Med. 2016 Apr;11(4):1417-1424. Epub 2016 Jan 29.
Contained in the Mongolian volumes of Chinese Materia Medica, Lomatogonium rotatum Fries ex Nym. may reduce blood lipid levels and prevent obesity; however, its exact mechanism of action remains unclear. The present study investigated the hypolipidemic and obesity-inhibiting effects of four similarly structured flavonoids extracted from L. rotatum. According to a well-established method, flavonoids such as decussatin were extracted from the whole herb of L. rotatum, and male Wistar rats were subsequently fed a high-fructose diet supplemented with flavonoids (20 mg/kg) for 12 weeks. The levels of total cholesterol, triglyceride (TG), low-density lipoprotein-cholesterol and high-density lipoprotein-cholesterol (HDL-C) were detected. In addition, hepatic and epididymal adipose tissues were weighed, and levels of blood glucose, alanine aminotransferase, aspartate aminotransferase, non-esterified fatty acid, insulin and leptin were determined.
3.Epigallocatechin-3-gallate ameliorates erectile function in aged rats via regulation of PRMT1/DDAH/ADMA/NOS metabolism pathway.
Chen D, Zhang KQ, Li B, Sun DQ, Zhang H, Fu Q1. Asian J Androl. 2016 Apr 15. doi: 10.4103/1008-682X.178486. [Epub ahead of print]
Aging-related ED is predominantly attributed to neurovascular dysfunction mediated by NO suppression and increased oxidative stress in penis. The alterations of protein arginine methyltransferases 1 (PRMT1)/dimethylarginine dimethylaminohydrolase (DDAH)/asymmetrical dimethylarginine (ADMA)/NO synthase (NOS) pathway regulate NO production in the vascular endothelium. Epigallocatechin-3-gallate (EGCG) is one of the most abundant and antioxidative ingredients isolated from green tea. In the present study, 40 Sprague-Dawley rats were randomly distributed into four groups: one young rat group and three aged rat groups treated with daily gavage feedings of EGCG at doses of 0, 10 mg kg-1 and 100 mg kg-1 for 12 weeks, respectively. Erectile function was assessed by electrical stimulation of the cavernous nerves with intracavernous pressure (ICP) measurement. After euthanasia, penile tissue was investigated using Western blot and ELISA to assess the PRMT1/DDAH/ADMA/NOS metabolism pathway.
4.Does supplementation with green tea extract improve acne in post-adolescent women? A randomized, double-blind, and placebo-controlled clinical trial.
Lu PH1, Hsu CH2. Complement Ther Med. 2016 Apr;25:159-63. doi: 10.1016/j.ctim.2016.03.004. Epub 2016 Mar 7.
BACKGROUND: Green tea is believed to have beneficial effects in the prevention and treatment of acne.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products

CAS 24584-09-6 Dexrazoxane

(CAS: 24584-09-6)

Dexrazoxane is a cardioprotective compound against anthracyclines. It is highly protective in reducing anthracycline-induced cardiotoxicity and extravasation in...

CAS 116539-59-4 Duloxetine

(CAS: 116539-59-4)

Duloxetine is a serotonin-norepinephrine reuptake inhibitor (Ki=4.6 nM), used for major depressive disorder, generalized anxiety disorder, fibromyalgia and neur...

CAS 3184-59-6 Alipamide

(CAS: 3184-59-6)

Alipamide is a bio-active chemical with a sequence-specific threading tetra-intercalator with an extremely slow dissociation rate constant.

CAS 1208313-97-6 Ketone Ester

Ketone Ester
(CAS: 1208313-97-6)

a ketone ester given orally as R,S-1,3-butanediol acetoacetate diester (BD-AcAc(2)) would delay CNS-OT seizures in rats breathing hyperbaric oxygen (HBO(2)). Ad...

CAS 141433-60-5 Berberine chloride hydrate

Berberine chloride hydrate
(CAS: 141433-60-5)

The plant-based alkaloid berberine has potential therapeutic applications for breast cancer, although a better understanding of the genes and cellular pathways ...

CAS 6893-02-3 3,3,5-Triiodo-L-thyronine

(CAS: 6893-02-3)

3,3,5-Triiodo-L-thyronine(T3), an active metabolite of Thyroxine, could be effective in agonizing both thyroid hormone receptors TRα and TRβ so that might help ...

CAS 600-57-7 11beta-Hydroxyprogesterone

(CAS: 600-57-7)

11beta-Hydroxyprogesterone is a potent inhibitors of 11β-Hydroxysteroid dehydrogenase and can confer mineralocorticoid activity on corticosterone in the rat in ...

CAS 4204-99-3 MK190

(CAS: 4204-99-3)

MK190 is a synthetic bio-active chemical.

CP74725 sodium salt
(CAS: 111477-48-6)

CP74725 sodium salt is a bio-active chemical compound.

CAS 58546-55-7 Schisantherin B

Schisantherin B
(CAS: 58546-55-7)

Schisantherin B, source from the seeds of Schisandra chinensis (Turcz.) Baill., shows good effect in lowering the serum glutamic-pyruvic transaminase level of t...

(CAS: 1652591-81-5)

GSK-484, a benzoimidazole derivative, has been found to be an effective reversible PAD-4 inhibitor that could be significant in some inflammation and immune res...

(CAS: 865608-11-3)

CMPD101 is a selective GRK2/3 inhibitor with IC50 value is 54 nM for GRK3 and 32 nM for GRK2. It shows selectivity for GRK2/3 over GRK1/5. It can also reduce DA...

CAS 10331-57-4 Niclofolan

(CAS: 10331-57-4)

Niclofolan is a biphenyl anthelmintic compound. It is used orally towards the treatment of Fasciola hepatica infection. It is used for the control of cattle and...

CAS 141625-93-6 Dronedarone  HCl

Dronedarone HCl
(CAS: 141625-93-6)

Dronedarone HCl is a therapy for the treatment of patients with paroxysmal and persistent atrial fibrillation or atrial flutter.

(CAS: 1309783-00-3)

Remeglurant is a selective Metabotropic glutamate receptor 5 antagonist originated by Merz Pharmaceuticals. Phase-I for Drug-induced dyskinesia in USA was on-go...

CAS 113962-61-1 Cgp 13231

Cgp 13231
(CAS: 113962-61-1)

Cgp 13231 is the N-oxide metabolite of amocarzine

CAS 465-11-2 Gamabufotalin

(CAS: 465-11-2)

Gamabufotalin is a major bufadienolide of Chansu and has been used for cancer therapy due to its desirable metabolic stability and less adverse effect.

CAS 18623-44-4 iCRT5

(CAS: 18623-44-4)

iCRT5 is a Potent and cell-permeable β-catenin-responsive transcription (CRT) inhibitor (IC50 value of 18 nM for Wnt responsive STF16 luciferase). iCRT5 disrupt...

CAS 137624-14-7 Mesatlantin C

Mesatlantin C
(CAS: 137624-14-7)

Mesatlantin C is a natural compound.

CAS 1156-19-0 Tolazamide

(CAS: 1156-19-0)

Tolazamide, a sulphonylurea derivative, could be a hypoglycemic agent which is commonly used in Type 2 diabetes.

Chemical Structure

CAS 970-74-1 (-)-Epigallocatechin

Quick Inquiry

Verification code

Featured Items