(-)-Epigallocatechin - CAS 970-74-1
Catalog number:
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
(-)-Epigallocatechin is the most abundant flavonoid in green tea. It is a major green tea polyphenol with antioxidant, anti-inflammatory, and anticancer activities. It can bind to unfolded native polypeptides and prevent conversion to amyloid fibrils. It is a potent inhibitor of amyloidogenic cystatin I66Q amyloid fibril formation in vitro. It prevents amyloidogenic cystatin fibril formation by stabilizing the molecule in its native-like state as opposed to redirecting aggregation to disordered, amorphous aggregates. It induced the formation of hydroxyl radicals in E. faecalis. It has been shown to scavenge DPPH radicals and prevent the growth of several different AML cell lines at micromolar concentrations.
Publictions citing BOC Sciences Products
  • >> More
EGC; Epigallocatechin; l-Epigallocatechin; epi-Gallocatechin
1.A-type dimeric epigallocatechin-3-gallate (EGCG) is a more potent inhibitor against the formation of insulin amyloid fibril than EGCG monomer.
Nie RZ1, Zhu W1, Peng JM1, Ge ZZ1, Li CM2. Biochimie. 2016 Apr 12. pii: S0300-9084(16)30038-4. doi: 10.1016/j.biochi.2016.03.011. [Epub ahead of print]
Because fibrillary protein aggregates is regarded to be closely associated with many diseases such as Alzheimer's disease, diabetes, and Parkinson's disease, growing interest and researches have been focused on finding potential fibrillation inhibitors. In the present study, the inhibitory effects of epigallocatechin-3-gallate (EGCG) and A-type dimeric epigallocatechin-3-gallate (A-type EGCG dimer) on the formation of insulin fibrillation were compared by multi-dimensional approaches including thioflavin-T (ThT) fluorescence assay, 1-anilinonaphthalene-8-sulfonic (ANS) fluorescence assay, dynamic light scattering (DLS), transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectroscopy and circular dichroism (CD) spectroscopy. Our results confirmed that A-type EGCG dimer is a more potent inhibitor against the formation of bovine insulin amyloid fibril than EGCG. In addition, A-type EGCG dimer could not only inhibit insulin amyloid fibril formation, but also change the aggregation pathway and induce bovine insulin into amorphous aggregates.
2.Hypolipidemic effects of flavonoids extracted from Lomatogonium rotatum.
Bao L1, Hu L2, Zhang Y3, Wang YI1. Exp Ther Med. 2016 Apr;11(4):1417-1424. Epub 2016 Jan 29.
Contained in the Mongolian volumes of Chinese Materia Medica, Lomatogonium rotatum Fries ex Nym. may reduce blood lipid levels and prevent obesity; however, its exact mechanism of action remains unclear. The present study investigated the hypolipidemic and obesity-inhibiting effects of four similarly structured flavonoids extracted from L. rotatum. According to a well-established method, flavonoids such as decussatin were extracted from the whole herb of L. rotatum, and male Wistar rats were subsequently fed a high-fructose diet supplemented with flavonoids (20 mg/kg) for 12 weeks. The levels of total cholesterol, triglyceride (TG), low-density lipoprotein-cholesterol and high-density lipoprotein-cholesterol (HDL-C) were detected. In addition, hepatic and epididymal adipose tissues were weighed, and levels of blood glucose, alanine aminotransferase, aspartate aminotransferase, non-esterified fatty acid, insulin and leptin were determined.
3.Epigallocatechin-3-gallate ameliorates erectile function in aged rats via regulation of PRMT1/DDAH/ADMA/NOS metabolism pathway.
Chen D, Zhang KQ, Li B, Sun DQ, Zhang H, Fu Q1. Asian J Androl. 2016 Apr 15. doi: 10.4103/1008-682X.178486. [Epub ahead of print]
Aging-related ED is predominantly attributed to neurovascular dysfunction mediated by NO suppression and increased oxidative stress in penis. The alterations of protein arginine methyltransferases 1 (PRMT1)/dimethylarginine dimethylaminohydrolase (DDAH)/asymmetrical dimethylarginine (ADMA)/NO synthase (NOS) pathway regulate NO production in the vascular endothelium. Epigallocatechin-3-gallate (EGCG) is one of the most abundant and antioxidative ingredients isolated from green tea. In the present study, 40 Sprague-Dawley rats were randomly distributed into four groups: one young rat group and three aged rat groups treated with daily gavage feedings of EGCG at doses of 0, 10 mg kg-1 and 100 mg kg-1 for 12 weeks, respectively. Erectile function was assessed by electrical stimulation of the cavernous nerves with intracavernous pressure (ICP) measurement. After euthanasia, penile tissue was investigated using Western blot and ELISA to assess the PRMT1/DDAH/ADMA/NOS metabolism pathway.
4.Does supplementation with green tea extract improve acne in post-adolescent women? A randomized, double-blind, and placebo-controlled clinical trial.
Lu PH1, Hsu CH2. Complement Ther Med. 2016 Apr;25:159-63. doi: 10.1016/j.ctim.2016.03.004. Epub 2016 Mar 7.
BACKGROUND: Green tea is believed to have beneficial effects in the prevention and treatment of acne.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products

LY 54761
(CAS: 18381-60-7)

CAS 81066-45-7 Kauniolide

(CAS: 81066-45-7)

Kauniolide is a natural compound.

CAS 1141777-14-1 Emixustat

(CAS: 1141777-14-1)

Emixustat, a novel visual cycle modulator, is a nonretinoid compound that directly inhibits RPE65, but does not bind to RAR/<br/>RXR retinoid receptors or antag...

CAS 15299-99-7 Napropamid

(CAS: 15299-99-7)

Napropamid is a selective systemic amide herbicide which is used against a number of annual grasses and broad-leaved weeds for inhibiting root development and g...

CAS 3055-99-0 Polidocanol

(CAS: 3055-99-0)

A nonionic surfactant.

CAS 1613695-14-9 SGC-CBP30

(CAS: 1613695-14-9)

SGC-CBP30 is a potent and selective inhibitor of CREBBP (CBP) and EP300; which are general transcriptional co-activators. Mutations of CREBBP and EP300 lead to...

CAS 58-46-8 Tetrabenazine

(CAS: 58-46-8)

Tetrabenazine is a VMAT-inhibitor used for treatment of hyperkinetic movement disorder. It is a monoamine-depleting and a dopamine-receptor-blocking drug and is...

CAS 75621-03-3 CHAPS

(CAS: 75621-03-3)

CHAPS is a zwitterionic nondenaturing detergent for solubilizing membrane proteins. It is often used as a detergent in the solubilization and purification of me...

(CAS: 1159501-31-1)

This molecular is a prodrug of ACT-246475 which is a selective P2Y12 receptor antagonist with a wider therapeutic window in the rat model. ACT-281959 is the pho...

(CAS: 202822-23-9)

CAS 144092-28-4 Xenin

(CAS: 144092-28-4)

Xenin, a 25-amino acid peptide initially isolated from human gastric mucosa, has 6 C-terminal amino acids in common with amphibian xenopsin. Xenin may stimulate...

CAS 76494-51-4 Ligustrazine Hydrochloride

Ligustrazine Hydrochloride
(CAS: 76494-51-4)

Ligustrazine Hydrochloride is a natural product extracted from the rhizomes of Ligusticum chuanxiong Hort. It displayed a protection effect on injured ECV304 ce...

(CAS: 175556-12-4)

RO-46-8443, a benzenesulfonamide derivative, has been found to be a non-peptide endothelin ETB receptor antagonist and could probably be useful in some biologic...

CAS 483-34-1 (-)-Isocorypalmine

(CAS: 483-34-1)

(-)-Isocorypalmine is a alkaloid, as a metabolite of the isoquinoline.

LY 135114
(CAS: 126254-82-8)

LY 135114 is a metabolite of LY 195448. LY195448 is a Alpha adrenergic receptor originate by Eli Lilly. But clinical trials for the treatment of cancer had been...

(CAS: 202822-21-7)

CAS 481-72-1 Aloe-emodin

(CAS: 481-72-1)

Aloe-emodin is an interferon-inducing agent with IC50 of about 1 μg/mL for JEV and of about 0.33 μg/mL for EV71.

CAS 191282-48-1 C75 trans

C75 trans
(CAS: 191282-48-1)

trans-Tetrahydro-4-methylene-2-octyl-5-oxo-3-furancarboxylic Acid is a well-known fatty acid synthase (FAS) inhibitor. Studies show that trans-Tetrahydro-4-meth...

CAS 90-01-7 2-Hydroxybenzyl alcohol

2-Hydroxybenzyl alcohol
(CAS: 90-01-7)

2-Hydroxybenzyl alcohol could be extracted from salix bark. And this is the reason for 2-Hydroxybenzyl alcohol being named "Salicyl alcohol". It is an precursor...

CAS 6106-24-7 Disodium tartrate dihydrate

Disodium tartrate dihydrate
(CAS: 6106-24-7)

Disodium tartrate dihydrate is a Acid phosphatase inhibitor used in buffers for molecular biology and cell culture applications.

Chemical Structure

CAS 970-74-1 (-)-Epigallocatechin

Quick Inquiry

Verification code

Featured Items