Epiberberine - CAS 6873-09-2
Catalog number:
6873-09-2
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C20H18NO4
Molecular Weight:
336.36
COA:
Inquire
Targets:
Others
Description:
Epiberberine, a natural bioactive alkaloid, has anti-adipogenic effect and is found to have potential effect in blocking cox-2 to get a chemopreventive property against colon tumor.
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Purity:
>98%
Appearance:
Powder
Synonyms:
epiberberine;11,12-Dihydro-8,9-dimethoxybenzo[a]-1,3-benzodioxolo[4,5-g]quinolizinium;Epiberberine Chloride;BerbiniuM
Solubility:
10 mM in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
Epiberberine has been found to have anti-adipogenic effect and is found to have potential effect in blocking cox-2.
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
InChIKey:
FPJQGFLUORYYPE-UHFFFAOYSA-N
InChI:
InChI=1S/C20H18NO4/c1-22-18-8-13-5-6-21-10-15-12(3-4-17-20(15)25-11-24-17)7-16(21)14(13)9-19(18)23-2/h3-4,7-10H,5-6,11H2,1-2H3/q+1
Canonical SMILES:
COC1=C(C=C2C(=C1)CC[N+]3=C2C=C4C=CC5=C(C4=C3)OCO5)OC
1.Epiberberine reduces serum cholesterol in diet-induced dyslipidemia Syrian golden hamsters via network pathways involving cholesterol metabolism.
Zou ZY1, Hu YR1, Ma H1, Feng M2, Li XG3, Ye XL4. Eur J Pharmacol. 2016 Mar 5;774:1-9. doi: 10.1016/j.ejphar.2015.11.017. Epub 2015 Dec 1.
This study aimed to evaluate the cholesterol-lowering effect of epiberberine in dyslipidemia Syrian golden hamsters induced by high fat and high cholesterol (HFHC) diet and its regulation mechanism on some key genes involved in cholesterol metabolism. Hamsters were divided into six groups: normal control group (NC), HFHC group, simvastatin (Sim) and three doses of epiberberine group. The body weight, organs weight and serum lipid levels, as well as total cholesterol (TC) and total bile acids (TBA) levels in liver and feces were determined. Furthermore, the antidyslipidemia effect of epiberberine on key genes involved in cholesterol biosynthesis, uptake, conversion and elimination such as 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), low density lipoprotein receptor (LDL receptor), 7-alpha-hydroxylase (CYP7A1) and apical sodium dependent bile acid transporter (ASBT) were investigated. The results showed that epiberberine at high dosage significantly reduced serum TC, low density lipoprotein cholesterol (LDL-c) and TBA levels by 20.
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CAS 6873-09-2 Epiberberine

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