Epetraborole HCl - CAS 1234563-16-6
Catalog number:
1234563-16-6
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C11H17BClNO4
Molecular Weight:
373.52
COA:
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Targets:
Leucyl-tRNA synthetase
Description:
This active molecular is a selective leucyl-tRNA synthetase inhibitor under the development of Anacor Pharmaceuticals and GlaxoSmithKline as a novel boron-containing antibiotic. Epetraborole was applicated in treatment of infections caused by multidrug-resistant Gram-negative pathogens. All Clostridium perfringens strains had Epetraborole MICs of >32 μg/ml. In Oct 2012, Phase-II for Urinary tract infections in Russia was discontinued. In Mar 2013, Phase-II for Gram-negative infections in USA was Suspended.
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Purity:
98%
Appearance:
White to off-white solid powder
Synonyms:
UNII-MM0NZY12FA; MM0NZY12FA;SCHEMBL1980656; CHEMBL3527377;3-[[(3S)-3-(aminomethyl)-1-hydroxy-3H-2,1-benzoxaborol-7-yl]oxy]propan-1-ol;hydrochloride; AN-3365; GSK-052;
Solubility:
Soluble in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
Urinary tract infections;Gram-negative infections
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
InChIKey:
DADYQGIQOBJGIW-HNCPQSOCSA-N
InChI:
InChI=1S/C11H16BNO4.ClH/c13-7-10-8-3-1-4-9(16-6-2-5-14)11(8)12(15)17-10;/h1,3-4,10,14-15H,2,5-7,13H2;1H/t10-;/m1./s1
Canonical SMILES:
B1(C2=C(C=CC=C2OCCCO)C(O1)CN)O.Cl
Current Developer:
Anacor Pharmaceuticals; GlaxoSmithKline
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Epetraborole HCl
(CAS: 1234563-16-6)

This active molecular is a selective leucyl-tRNA synthetase inhibitor under the development of Anacor Pharmaceuticals and GlaxoSmithKline as a novel boron-conta...

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