ENMD-2076 - CAS 934353-76-1
Catalog number:
934353-76-1
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
COA:
Inquire
Targets:
Aurora Kinase
Description:
ENMD-2076 is an orally-active, Aurora A/angiogenic kinase inhibitor with a unique kinase selectivity profile and multiple mechanisms of action. ENMD-2076 has been shown to inhibit a distinct profile of angiogenic tyrosine kinase targets in addition to the Aurora A kinase. Aurora kinases are key regulators of mitosis (cell division), and are often over-expressed in human cancers. ENMD-2076 also targets the VEGFR, Flt-3 and FGFR3 kinases which have been shown to play important roles in the pathology of several cancers. ENMD-2076 has shown promising activity in Phase 1 clinical trials in solid tumor cancers, leukemia, and multiple myeloma. ENMD-2076 is currently in a Phase 2 trial for ovarian cancer, and preclinical and clinical activities are ongoing in assessing the compound's applicability for other forms of cancer.
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Appearance:
white solid powder
Synonyms:
ENMD-2076; ENMD 2076; ENMD2076.
MSDS:
Inquire
Current Developer:
EntreMed, Inc.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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CAS 934353-76-1 ENMD-2076

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