Enilconazole - CAS 35554-44-0
Catalog number:
35554-44-0
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C14H14Cl2N2O
Molecular Weight:
297.18
COA:
Inquire
Targets:
Antifungal
Description:
Enilconazole Is An Agricultiral Fungicide, particularly in the growing of citrus fruits, also used as a topical antimycotic.
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Purity:
≥95%
Appearance:
Solid powder
Synonyms:
Imazalil: 1-[2-(2,4-dichlorophenyl)-2-prop-2-enoxyethyl]imidazole;
Solubility:
Soluble in DMSO
Storage:
Store at 2-8 °C
MSDS:
Inquire
Application:
Used in agriculture, particularly in the growing of citrus fruits.
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
Boiling Point:
347 °C at 760 mmHg
Melting Point:
52~53.0 °C
Density:
1.348
InChIKey:
PZBPKYOVPCNPJY-UHFFFAOYSA-N
InChI:
1S/C14H14Cl2N2O/c1-2-7-19-14(9-18-6-5-17-10-18)12-4-3-11(15)8-13(12)16/h2-6,8,10,14H,1,7,9H2
Canonical SMILES:
C=CCOC(CN1C=CN=C1)C2=C(C=C(C=C2)Cl)Cl
Current Developer:
BASF
1.Azole resistance in canine and feline isolates of Aspergillus fumigatus.
Talbot JJ1, Kidd SE2, Martin P3, Beatty JA1, Barrs VR4. Comp Immunol Microbiol Infect Dis. 2015 Oct;42:37-41. doi: 10.1016/j.cimid.2015.08.002. Epub 2015 Aug 28.
Azole resistance is an emerging cause of treatment failure in humans with aspergillosis. The aim of this study was to determine if azole resistance is emerging in Aspergillus fumigatus isolates from canine and feline sino-nasal aspergillosis cases. Susceptibilities of isolates collected between 1988 and 2014 from 46 dogs and 4 cats to itraconazole, posaconazole, voriconazole, fluconazole and ketoconazole were assessed using Sensititre YeastOne microdilution trays; and to enilconazole and clotrimazole, following the CLSI M38-A2 standard. For the majority of isolates MICs were high for ketoconazole, low for enilconazole and clotrimazole, and less than established epidemiological cut-off values for itraconazole, posaconazole and voriconazole. One canine isolate from 1992 had multiazole resistance and on Cyp51A gene sequencing a mutation associated with azole resistance (F46Y) was detected. There is no evidence of emerging azole resistance among A.
2.Kennel Disinfectants for Microsporum canis and Trichophyton sp.
Moriello KA1. Vet Med Int. 2015;2015:853937. doi: 10.1155/2015/853937. Epub 2015 Feb 11.
The antifungal efficacy of commonly used kennel disinfectants for large surfaces was tested using naturally infective material from untreated animals (M. canis and Trichophyton sp.) soaked and macerated but unfiltered leaving visible fluorescing hairs and/or scales in the test inoculum to create a robust challenge. Disinfectants included sodium hypochlorite (1 : 32 and 1 : 100), enilconazole (1 : 100), accelerated hydrogen peroxide (1 : 16), potassium peroxymonosulfate (1% and 2%), and calcium hypochlorite "dry bleach." Disinfectants were tested at a 1 : 10, 1 : 5, and 1 : 1 dilution of test inoculum to disinfectant with a 10 min contact time. Good efficacy was defined as a disinfectant resulting in no growth. Control plates grew >300 colonies of each pathogen per plate. Enilconazole, sodium hypochlorite (all dilutions), accelerated hydrogen peroxide, and 2% potassium peroxymonosulfate (but not 1%) inhibited all growth of both pathogens at 1 : 10, 1 : 5, and 1 : 1 dilutions.
3.Enantioseparation of the fungicide imazalil in orange juice by chiral HPLC. Study on degradation rates and extractive/enrichment techniques.
Ruiz-Rodríguez L1, Aguilar A1, Díaz AN1, Sánchez FG2. Food Chem. 2015 Jul 1;178:179-85. doi: 10.1016/j.foodchem.2015.01.004. Epub 2015 Jan 12.
Imazalil ([1-(β-allyloxy-2,4-dichlorophenethyl)imidazole]) is a systemic chiral fungicide used in postharvest protection of citruses against fungi development for during storage and transportation. The chemical structure of imazalil shows an asymmetric carbon in the C7 position. These enantiomers may have different toxicity. A method for both chiral enantiomers extraction and determination in orange juice is developed in order to provide their concentration and to study the degradation rates in orange juice. Spiked imazalil was extracted from orange juice by dispersive liquid-liquid micro extraction and solid phase extraction. Recovery assays of imazalil enantiomers from spiked orange juice samples showed that solid phase extraction is a better choice in order to obtain higher recovery values. Obtained chromatographic data show that within 24h the (-)-imazalil enantiomer decreases from 0.548 to 0.471 (expressed as enantiomer fraction).
4.Equine Dermatophytosis due to Trichophyton bullosum, a Poorly Known Zoophilic Dermatophyte Masquerading as T. verrucosum.
Lyskova P1, Hubka V2,3,4, Petricakova A5, Dobias R6, Cmokova A7,8, Kolarik M7,8. Mycopathologia. 2015 Dec;180(5-6):407-19. doi: 10.1007/s11046-015-9931-0. Epub 2015 Aug 20.
Trichophyton bullosum is a zoophilic dermatophyte from the Arthroderma benhamiae complex with a poorly known distribution. In this study, we report a case of dermatophytosis caused by T. bullosum in a 6-year-old male horse who had a skin lesion located in a saddle area. The infection spread rapidly to the upper chest and to both sides of the trunk. The dermatophyte was isolated in culture and identified by sequence analysis of the internal transcribed spacer regions (ITS rDNA). To date, this is the first verified case of animal infection due to T. bullosum in Europe following the 2012 report of human infection in France. We hypothesize that this species can be relatively common in horses and donkeys, but it is confused with other zoophilic species responsible for infections with similar clinical manifestations, and when isolated in culture, it is misidentified as the phenotypically similar T. verrucosum. Previous cases of dermatophytosis caused by T.
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CAS 35554-44-0 Enilconazole

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