Endothelin 1 swine, human - CAS 117399-94-7
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Endothelin Receptor
Endothelin 1 (swine, human), a vasoconstrictor increased in plasma and explants of patients with uterine leiomyomas, is a synthetic peptide with the sequence of human and swine Endothelin 1 and acts through two types of receptors ETA and ETB.
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L-cysteinyl-L-seryl-L-cysteinyl-L-seryl-L-seryl-L-leucyl-L-methionyl-L-alpha-aspartyl-L-lysyl-L-alpha-glutamyl-L-cysteinyl-L-valyl-L-tyrosyl-L-phenylalanyl-L-cysteinyl-L-histidyl-L-leucyl-L-alpha-aspartyl-L-isoleucyl-L-isoleucyl-L-tryptophan (1->15),(3->11)-bis(disulfide); H-Cys(1)-Ser-Cys(2)-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys(2)-Val-Tyr-Phe-Cys(1)-His-Leu-Asp-Ile-Ile-Trp-OH
Store in a cool and dry place (or refer to the Certificate of Analysis).
Boiling Point:
2467.3±65.0 ℃ at 760 Torr
1.273±0.06 g/cm3
Canonical SMILES:
1.Plasma endothelin-1 in acute heart failure: pathophysiological and preanalytical considerations.
Monneret D1, Roche F2, Bonnefont-Rousselot D3. Eur J Heart Fail. 2016 Apr 12. doi: 10.1002/ejhf.528. [Epub ahead of print]
2.Evidence of substance P autocrine circuitry that involves TNF-α, IL-6, and PGE2 in endogenous pyrogen-induced fever.
Brito HO1, Barbosa FL1, Reis RC1, Fraga D1, Borges BS2, Franco CR2, Zampronio AR3. J Neuroimmunol. 2016 Apr 15;293:1-7. doi: 10.1016/j.jneuroim.2016.01.016. Epub 2016 Jan 27.
Substance P (SP) is involved in fever that is induced by lipopolysaccharide (LPS) but not by interleukin-1β or macrophage inflammatory protein-1α. Intracerebroventricular (i.c.v.) administration of the neurokinin-1 (NK1) receptor antagonist SR140333B in rats reduced fever that was induced by an i.c.v. injection of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), prostaglandin E2 (PGE2), corticotropin-releasing factor (CRF), endothelin-1 (ET-1), and morphine (MOR). Furthermore, an i.c.v. injection of SP induced a febrile response that was inhibited by indomethacin concomitant with an increase in PGE2 levels in cerebrospinal fluid. Lipopolysaccharide and PGE2 caused higher expression and internalization of NK1 receptors in the hypothalamus which were prevented by SR140333B. These data suggest that SP is an important mediator of fever, in which it induces a prostaglandin-dependent response and is released after TNF-α, IL-6, PGE2, CRF, endogenous opioids, and ET-1.
3.The heart and pulmonary arterial hypertension in systemic sclerosis.
Vandecasteele EH1, De Pauw M1, Brusselle G2, Decuman S3,4, Piette Y5, De Keyser F3,5, Smith V3,5. Acta Clin Belg. 2016 Feb 5:1-18. [Epub ahead of print]
Systemic sclerosis (SSc) is an autoimmune connective tissue disease characterized by vasculopathy and progressive fibrosis of the skin and visceral organs (gastrointestinal tract, heart, kidneys and lungs). Although the prevalence is low, SSc is a disease with high morbidity and mortality. Since pulmonary arterial hypertension (PAH) associated with SSc (SSc-PAH) and clinically evident cardiac involvement is associated with increased mortality, the cardiac complications and PAH in SSc are reviewed. Both diffuse cutaneous (DcSSc) and limited cutaneous (LcSSc) subgroups are at risk for cardiac involvement and SSc-PAH. Cardiac involvement can be divided in pericardial involvement, myocardial involvement and rhythm disturbances and mostly occurs asymptomatically. However, when symptomatic, it is associated with a poor prognosis. Screening for asymptomatic cardiac involvement should be considered in SSc in order to initiate treatment in an early stage.
4.Low-Level Blast Exposure Increases Transient Receptor Potential Vanilloid 1 (TRPV1) Expression in the Rat Cornea.
Por ED1, Choi JH1, Lund BJ1. Curr Eye Res. 2016 Apr 6:1-8. [Epub ahead of print]
BACKGROUND: Blast-related ocular injuries sustained by military personnel have led to rigorous efforts to elucidate the effects of blast exposure on neurosensory function. Recent studies have provided some insight into cognitive and visual deficits sustained following blast exposure; however, limited data are available on the effects of blast on pain and inflammatory processes. Investigation of these secondary effects of blast exposure is necessary to fully comprehend the complex pathophysiology of blast-related injuries. The overall purpose of this study is to determine the effects of single and repeated blast exposure on pain and inflammatory mediators in ocular tissues.
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CAS 117399-94-7 Endothelin 1 swine, human

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