Emodin - CAS 518-82-1
Catalog number: B0084-290905
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C15H10O5
Molecular Weight:
270.24
COA:
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Targets:
NF-κB
Description:
Emodin is a naturally occurring anthraquinone present in the roots and barks of numerous plants. It exerts antiproliferative effects in cancer cells that are regulated by different signaling pathways.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-290905 50 g $229 In stock
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Purity:
>98%
Synonyms:
Emodol; Frangula emodin
MSDS:
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InChIKey:
RHMXXJGYXNZAPX-UHFFFAOYSA-N
InChI:
InChI=1S/C15H10O5/c1-6-2-8-12(10(17)3-6)15(20)13-9(14(8)19)4-7(16)5-11(13)18/h2-5,16-18H,1H3
Canonical SMILES:
CC1=CC(=C2C(=C1)C(=O)C3=CC(=CC(=C3C2=O)O)O)O
1.[Research progress in anti-tumor effect of emodin].
Lin WF, Wang C, Ling CQ. Zhongguo Zhong Yao Za Zhi. 2015 Oct;40(20):3937-40.
Emodin is one of the main active ingredient of Rheum palmatum, and has anti-inflammatory, anti-bacterial, anti-viral and other effects. In recent years, it arouse concern since it has a significant anti-tumor effect with low toxicity. In this paper we mainly report the anti-cancer effects of emodin according to the studies of the past five years, including four parts such as inhibit tumor growth, inhibit migration and invasion, enhance the efficacy of combination therapy, increase chemosensitivity and attenuated side effects. We hope that our work may provide a reference for further study.
2.Erratum to "Aloe-Emodin Protects RIN-5F (Pancreatic β-cell) Cell from Glucotoxicity via Regulation of Pro-Inflammatory Cytokine and Downregulation of Bax and Caspase 3" [Biomol. Ther. 24 (2016) 49-56].
Alshatwi AA1, Subash-Babu P1. Biomol Ther (Seoul). 2016 May 1;24(3):346. doi: 10.4062/biomolther.2016.346.
The authors request to change the corresponding author's name as Ali A Alshatwi* from P. Subash-Babu in author list.
3.IDH2 knockdown sensitizes tumor cells to emodin cytotoxicity in vitro and in vivo.
Ku HJ1, Kwon OS1, Kang BS1, Lee DS1, Lee HS1, Park JW1. Free Radic Res. 2016 Apr 17:1-24. [Epub ahead of print]
Although reactive oxygen species (ROS) work as second messengers at sublethal concentrations, higher levels of ROS can kill cancer cells. Since cellular ROS levels are determined by a balance between ROS generation and removal, the combination of ROS generators and the depletion of reducing substances greatly enhance ROS levels. Emodin (1,3,8-trihydroxy-6-methyl anthraquinone), a natural anthraquinone derivative from the root and rhizome of numerous plants, is a ROS generator that induces apoptosis in cancer cells. The major enzyme to generate mitochondrial NADPH is the mitochondrial isoenzyme of NADP+-dependent isocitrate dehydrogenase (IDH2). In this report, we demonstrate that IDH2 knockdown effectively enhances emodin-induced apoptosis of mouse melanoma B16F10 cells through the regulation of ROS generation. Our findings suggest that suppression of IDH2 activity results in perturbation of the cellular redox balance and, ultimately, exacerbates emodin-induced apoptotic cell death in B16F10 cells.
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CAS 518-82-1 Emodin

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