Emedastine Difumarate - CAS 87233-62-3
Catalog number:
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Histamine Receptor
Emedastine is a H1 receptor antagonist. It is a second generation antihistamine. Emedastine can block the action of histamine that causes allergic symptoms. It can be used in eye drops to alleviate the symptoms of allergic conjunctivitis.
Publictions citing BOC Sciences Products
  • >> More
Emedastine fumarate; Rapimine; AL-3432A; DSSTox_CID_26911; KB 2413; KB-2413; KG 2413; KG-2413; Emadine; 1-(2-Ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)benzimidazole Difumarat
Soluble in DMSO
-20℃ Freezer
Allergic conjunctivitis; Allergic rhinitis; Atopic dermatitis; Dermatitis; Urticaria
Quality Standard:
Shelf Life:
2 month in rt, long tim
Canonical SMILES:
Current Developer:
1.Onset and duration of action of ketotifen 0.025% and emedastine 0.05% in seasonal allergic conjunctivitis : efficacy after repeated pollen challenges in the vienna challenge chamber.
Horak F1, Stübner P, Zieglmayer R, Kawina A, Moser M, Lanz R. Clin Drug Investig. 2003;23(5):329-37.
OBJECTIVE: To compare the efficacy, onset and duration of action, and the safety of ketotifen fumarate 0.025% ophthalmic solution and emedastine difumarate 0.05% ophthalmic solution in subjects with seasonal allergic conjunctivitis (SAC) induced by allergen exposure, using the Vienna Challenge Chamber model.
2.Efficacy of olopatadine HCI 0.1%, ketotifen fumarate 0.025%, epinastine HCI 0.05%, emedastine 0.05% and fluorometholone acetate 0.1% ophthalmic solutions for seasonal allergic conjunctivitis: a placebo-controlled environmental trial.
Borazan M1, Karalezli A, Akova YA, Akman A, Kiyici H, Erbek SS. Acta Ophthalmol. 2009 Aug;87(5):549-54. doi: 10.1111/j.1755-3768.2008.01265.x. Epub 2008 Jul 9.
PURPOSE: We aimed to compare the clinical efficacy and ocular surface variables of olopatadine, ketotifen fumarate, epinastine, emedastine and fluorometholone acetate ophthalmic solutions in preventing the signs and symptoms of seasonal allergic conjunctivitis (SAC).
3.Randomized, double-masked, placebo-controlled comparison of the efficacy of emedastine difumarate 0.05% ophthalmic solution and ketotifen fumarate 0.025% ophthalmic solution in the human conjunctival allergen challenge model.
D'Arienzo PA1, Leonardi A, Bensch G. Clin Ther. 2002 Mar;24(3):409-16.
BACKGROUND: Emedastine difumarate 0.05% ophthalmic solution and ketotifen fumarate 0.025% ophthalmic solution are 2 topical antiallergic agents available in the United States and other countries. Emedastine is indicated for the temporary relief of the signs and symptoms of allergic conjunctivitis. Ketotifen is indicated for the temporary relief of ocular itching caused by allergic conjunctivitis.
4.[Anti-allergic effects of 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)benzimidazole fumarate (KB-2413)].
Saito T, Nishimura N, Tajima S, Fukuda T, Ito K. Nihon Yakurigaku Zasshi. 1987 Feb;89(2):55-62.
The effects of KB-2413 on four types of allergic reactions classified by Coombs and Gell were investigated. KB-2413 inhibited homologous passive cutaneous anaphylaxis and passive anaphylactic bronchoconstriction in guinea pigs mediated by IgE-like antibody, and ED50 values were 0.0017 mg/kg, p.o., and 0.022 mg/kg, p.o., respectively. KB-2413 also inhibited IgG-mediated anaphylactic bronchoconstriction in guinea pigs actively sensitized with egg albumin. Both complement-dependent immune hemolysis and complement-independent hypotonic hemolysis were inhibited by KB-2413 in a concentration-dependent manner. KB-2413 had no effect on the Forssman systemic reaction. The passive Arthus reaction in guinea pigs sensitized with anti-egg albumin rabbit serum was unaffected by KB-2413. However, the early stage of the active Arthus reaction in rabbits sensitized with egg albumin was inhibited. KB-2413 had an inhibitory effect on the efferent phase of delayed-type hypersensitivity induced by picryl chloride (PC-DTH) in mice.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Histamine Receptor Products

CAS 34839-70-8 Metiamide

(CAS: 34839-70-8)

Metiamide is developed from another burimamide, used as a histamine H2 receptor antagonist.

CAS 113806-05-6 Olopatadine

(CAS: 113806-05-6)

This active molecular is an antihistamine, anticholinergic and mast cell stabilizer. Olopatadine blocks the action of endogenous histamine. It is used to treat ...

CAS 10246-75-0 Hydroxyzine pamoate

Hydroxyzine pamoate
(CAS: 10246-75-0)

Hydroxyzine pamoate, a derivative of hydroxyzine, is a histamine H1-receptor antagonist that has been used as anxiolytic and antihistaminic so that it is probab...

CAS 85604-00-8 Zaltidine

(CAS: 85604-00-8)

Zaltidine is an effective but hepatotoxic H2-receptor antagonist. It has higher incidence of hepatic damage than with commonly used H2-receptor antagonists. It ...

CAS 100981-43-9 Ebrotidine

(CAS: 100981-43-9)

Ebrotidine(FI 3542), a competitive H2-receptor antagonist, has gastroprotective activity under the condition of gastric mucosal damage caused by some stress res...

CAS 7456-24-8 Fonazine

(CAS: 7456-24-8)

Dimetotiazine is a histamine H1 receptor antagonist. It is a phenothiazine drug used for the treatment of migraine.

CAS 99291-25-5 Levodropropizine

(CAS: 99291-25-5)

Levodropropizine possess anti-allergic and inhibits histamine receptor, reduces cough by interfering with stimulus activation of peripheral endings of sensory n...

CAS 51-45-6 Histamine

(CAS: 51-45-6)

Histamine is an organic nitrogenous compound produced by basophils and by mast cells found in nearby connective tissues.

CAS 13461-01-3 aceprometazine

(CAS: 13461-01-3)

Aceprometazine is a Histamine H1 receptor antagonist as an approved drug. It can be used in combination with meprobamate for the treatment of sleep disorders su...

CAS 100299-08-9 Pemirolast potassium

Pemirolast potassium
(CAS: 100299-08-9)

Pemirolast potassium (BMY 26517) is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent.

CAS 83881-51-0 Cetirizine

(CAS: 83881-51-0)

Cetirizine, a second-generation antihistamine, is a major metabolite of hydroxyzine. It is a racemic selective H1 receptor inverse agonist. It is used in cutane...

CAS 1028327-66-3 VUF10460

(CAS: 1028327-66-3)

VUF10460 is a specific non-imidazole histamine H4 receptor agonist (pKi= 7.46, 8.22 for rat H4 receptor and human H4 receptor respectively) with 50-fold selecti...

CAS 5636-83-9 Dimethindene

(CAS: 5636-83-9)

Dimethindene is a selective histamine H1 antagonist. It binds to the histamine H1 receptor. It is an antiallergic drug and is used in hypersensitivity reactions...

CAS 2508-72-7 Antazoline hydrochloride

Antazoline hydrochloride
(CAS: 2508-72-7)

Antazoline HCl is a first generation antihistamine, binding to the histamine H1 receptor and blocking the action of endogenous histamine.

(CAS: 103294-47-9)

LY-150310 is a histamine H1-receptor antagonist. It could alter prostanoid concentrations in vitro and in vivo.

CAS 1163-36-6 Clemizole hydrochloride

Clemizole hydrochloride
(CAS: 1163-36-6)

The hydrochloride salt form of Clemizole that has hepatitis C antiviral effect through restraining NS4B function and could also be used as an anticonvulsant in ...

CAS 3978-86-7 Azatadine dimaleate

Azatadine dimaleate
(CAS: 3978-86-7)

Azatadine is an histamine and cholinergic inhibitor with IC50 of 6.5 nM and 10 nM, respectively.

CAS 59-33-6 Pyrilamine maleate salt

Pyrilamine maleate salt
(CAS: 59-33-6)

Pyrilamine maleate salt is a first generation antihistamine and binds with high affinity to G(q/11) protein. It is commonly utilized as a radioligand binding as...

Bavisant dihydrochloride
(CAS: 929622-09-3)

Bavisant dihydrochloride is the dihydrochloride form of Bavisant, which is a highly selective, orally active antagonist of the human H3 receptor. It may be used...

(CAS: 1905481-36-8)

KDM5A-IN-1, a pyrrolidine amide compound, is an inhibitor histone demethylases.

Chemical Structure

CAS 87233-62-3 Emedastine Difumarate

Quick Inquiry

Verification code

Featured Items