Elubrixin - CAS 688763-64-6
Catalog number:
688763-64-6
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C17H17Cl2FN4O4S
Molecular Weight:
463.30
COA:
Inquire
Targets:
CXCR
Description:
Elubrixin is a interleukin 8 inhibitor and CXCR2 selective antagonist. It is potentially useful for Inflammatory bowel disease therapies. It inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans. It may be an effective agent in neutrophil-predominant diseases. It was developed by GlaxoSmithKline and was in clinic phase 2 trials, but now it is terminated.
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Purity:
98%
Appearance:
Solid powder
Synonyms:
1-(2-Chloro-3-fluorophenyl)-3-(4-chloro-2-hydroxy-3-piperazin-1-ylsulfonylphenyl)urea;SB-656933;SB656933;SB-656933-AAF;SB-656933-AAA;SB656933AAA;SB656933AAF;1-(4-Chloro-2-hydroxy-3-(piperazin-1-ylsulfonyl)phenyl)-3-(2-chloro-3-fluorophenyl)urea
Solubility:
Soluble in DMSO, not in water
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
Elubrixin is potentially useful for Inflammatory bowel disease therapies. It may be an effective agent in neutrophil-predominant diseases.
Quality Standard:
In-house standard
Quantity:
Milligrams-Grams
Density:
1.609±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
YQYFEGTYCUQBEI-UHFFFAOYSA-N
InChI:
InChI=1S/C17H17Cl2FN4O4S/c18-10-4-5-13(23-17(26)22-12-3-1-2-11(20)14(12)19)15(25)16(10)29(27,28)24-8-6-21-7-9-24/h1-5,21,25H,6-9H2,(H2,22,23,26)
Canonical SMILES:
C1CN(CCN1)S(=O)(=O)C2=C(C=CC(=C2O)NC(=O)NC3=C(C(=CC=C3)F)Cl)Cl
Current Developer:
Elubrixin was developed by GlaxoSmithKline and was in clinic phase 2 trials, but now it is terminated.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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