|Description||Eltoprazine hydrochloride is the hydrochloride form of Eltoprazine which is a serenic or antiaggressive agent. It acts as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor with Ki values of 40, 52 and 81 nM for 5-HT1A, 5-HT1B and 5-HT2C receptors respectively. It has been shown to reduce L-DOPA-induced dyskinesias in experimental models of Parkinson′s Disease and in human patients, although this effect was accompanied by a partial worsening of the therapeutic effect of l-dopa in vivo. It is used as a novel drug for the treatment of anxiety as well as other neurological and mental disorders. It was developed by PsychoGenics and Amarantus Bioscience, Inc.. It is in clinical stage 3.|
|Appearance||White to beige powder|
|Synonyms||Piperazine, 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-, monohydrochloride;1-(2,3-dihydro-1,4-benzodioxin-5-yl)piperazine hydrochloride;DU-28853 hydrochloride;DU28853 hydrochloride|
|Solubility||DMSO: ≥ 31 mg/mL, H2O: ≥ 28 mg/mL|
|Application||Eltoprazine hydrochloride has been shown to reduce L-DOPA-induced dyskinesias in experimental models of Parkinson′s Disease and in human patients. It is used as a novel drug for the treatment of anxiety as well as other neurological and mental disorders.|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Quantity||Grams to Kilograms|
|Melting Point||256-258 °C|
|Current Developer||Eltoprazine hydrochloride was developed by PsychoGenics and Amarantus Bioscience, Inc.. It is in clinical stage 3.|
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