Eliprodil - CAS 119431-25-3
Catalog number: 119431-25-3
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
NMDA Receptor
Eliprodil, a NR2B-NMDA receptor antagonist, was found to have neuroprotective activity in study of ischemia.
Publictions citing BOC Sciences Products
  • >> More
-(4-Chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol, SL 820715
DMSO: 17 mg/mL
Eliprodil is a NR2B-NMDA receptor antagonist that was found to have neuroprotective activity in study of ischemia.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Boiling Point:
474.1ºC at 760 mmHg
1.205 g/cm3
Canonical SMILES:
1.Effect of a neuroprotective drug, eliprodil on cardiac repolarisation: importance of the decreased repolarisation reserve in the development of proarrhythmic risk.
Lengyel C1, Dézsi L, Biliczki P, Horváth C, Virág L, Iost N, Németh M, Tálosi L, Papp JG, Varró A. Br J Pharmacol. 2004 Sep;143(1):152-8. Epub 2004 Aug 9.
1. The aim of this study was to analyse the effects of eliprodil, a noncardiac drug with neuroprotective properties, on the cardiac repolarisation under in vitro circumstances, under normal conditions and after the attenuation of the 'repolarisation reserve' by blocking the inward rectifier potassium current (I(K1)) current with BaCl(2). 2. In canine right ventricular papillary muscle by applying the conventional microelectrode technique, under normal conditions, eliprodil (1 microm) produced a moderate reverse rate-dependent prolongation of the action potential duration (7.4+/-1.5, 8.9+/-2.1 and 9.9+/-1.8% at cycle lengths of 300, 1000 and 5000 ms, respectively; n=9). 3. This effect was augmented in preparations where I(K1) was previously blocked by BaCl(2) (10 microm). BaCl(2) alone lengthened APD in a reverse frequency-dependent manner (7.0+/-1.3, 14.2+/-1.6 and 28.1+/-2.1% at cycle lengths of 300, 1000 and 5000 ms, respectively; n=8).
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related NMDA Receptor Products

(CAS: 153322-05-5)

Lanicemine, also know as AZD6765, has been to be a NMDA receptor antagonist that was once studiedd as a neuroprotective agent which was discontinued in 2007 and...

(CAS: 117928-94-6)

Rapastinel, a brain penetrable tetrapeptide, could be a partial agonist of NMDA receptor. It was already finished the Phase II trial for acting as an antidepres...

CAS 126453-07-4 (R)-CPP

(CAS: 126453-07-4)

(R)-CPP, a piperazine derivative, has been found to be an effective NMDA receptor antagonist.

CAS 130798-51-5 MDL 29951

MDL 29951
(CAS: 130798-51-5)

CAS 2379-57-9 DNQX

(CAS: 2379-57-9)

DNQX is a selective non-NMDA receptor antagonist and could probably be useful in the treatment of Alzheimer's disease.

CAS 1312991-83-5 threo Ifenprodil hemitartrate

threo Ifenprodil hemitartrate
(CAS: 1312991-83-5)

Threo Ifenprodil hemitartrate is the hemitartrate salt of threo ifenprodil, which is a NR2B subunit-selective NMDA receptor antagonist, as well as a potent σ re...

(CAS: 138047-56-0)

CP-283097 is NR2B N-Methyl-D-Aspartate receptor antagonist originated by Pfizer. Preclinical trials for the treatment of Migraine and Neurodegenerative disorder...

(CAS: 496054-87-6)

Radiprodil is a orally active and selective NMDA NR2B antagonist with a potential therapeutic agent in treatment of neuropathic pain and possibly other chronic ...

CAS 127910-31-0 CGP 37849

CGP 37849
(CAS: 127910-31-0)

CGP 37849 is a potent, selective and competitive NMDA receptor antagonist (Ki = 35 nM). CGP 37849 exhibits an anticonvulsant effect following oral administratio...

CAS 59-47-2 Mephenesin

(CAS: 59-47-2)

Mephenesin is an NMDA receptor antagonist, is a centrally acting muscle relaxant.

CAS 1227675-52-6 MNI-caged-NMDA

(CAS: 1227675-52-6)

MNI-caged-NMDA, NMDA caged with the photosensitive 4-methoxy-7-nitroindolinyl group, is used as a ligand for glutamate receptor subtypes in the isolation of pos...

CAS 13861-03-5 (R)-3-Carboxy-4-hydroxyphenylglycine

(CAS: 13861-03-5)

(R)-3-Carboxy-4-hydroxyphenylglycine has been found to be an antagonist of NMDA and AMPA/kainate receptor.

CAS 6384-92-5 NMDA

(CAS: 6384-92-5)

NMDA is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. Unlike glutamate, NM...

CAS 3106-85-2 Spaglumic acid

Spaglumic acid
(CAS: 3106-85-2)

Spaglumic acid is the most abundant peptide neurotransmitter in the mammalian CNS. Spaglumic acid is a weak activator of NMDA receptors and a highly selective a...

CAS 174575-40-7 SDZ 220-040

SDZ 220-040
(CAS: 174575-40-7)

SDZ 220-040 is a potent competitive antagonist at the NMDA receptor (pKi = 8.5).

Felbamate hydrate
(CAS: 1177501-39-1)

The hydrate of Felbamate which is an effective anticonvulsant agent. It was found to be clinically active for probably restraining the effectivity of NMDA.

CAS 684283-16-7 PPDA

(CAS: 684283-16-7)

PPDA is a subtype-selective NMDA receptor antagonist that preferentially binds to GluN2C/GluN2D (formally NR2C/NR2D) containing receptors (Ki= 0.096, 0.125, 0.3...

CAS 6893-26-1 D-Glutamic acid

D-Glutamic acid
(CAS: 6893-26-1)

D-Glutamic acid is a non-essential amino acid acting at NMDA receptors. D-Glutamic is less active than the L-isomer.

CAS 100828-16-8 (RS)-CPP

(CAS: 100828-16-8)

(RS)-CPP, a piperazin derivative, has been found to be an effective NMDA antagonist.

CAS 492-27-3 Kynurenic acid

Kynurenic acid
(CAS: 492-27-3)

Kynurenic acid is a product of L-Tryptophan metabolism. It is a non-selective antagonist at NMDA and AMPA/kainate receptors. It could block kainic acid neurotox...

Chemical Structure

CAS 119431-25-3 Eliprodil

Quick Inquiry

Verification code

Featured Items