|Description||Eletriptan induces concentration-dependent contractions of meningeal artery, coronary artery, and saphenous vein. The potency of Eletriptan is higher in meningeal artery than in coronary artery (86-fold) or saphenous vein (66-fold).|
SB 242084 is a brain-penetrant antagonist of 5-HT2C receptor which exhibits 158-fold selectivity for 5-HT2C (pKi= 9.0) over 5-HT2A receptor (pKi= 6.1-6.8) and 1...
Asenapine hydrochloride, also called Org 5222 and HSDB 8061, shows high affinity for numerous receptors including 5-HT receptor and adrenergic receptor. (pKi: 5...
SB 271046 Hydrochloride
SB 271046 Hydrochloride is the hydrochloride salt form of SB 271046. SB 271046 is an orally-available and selective antagonist of the serotonin (5-hydroxytrypta...
Vortioxetine is a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT with IC50 of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, r...
Tianeptine sodium is a selective serotonin reuptake enhancer (SSRE), used for treating major depressive episodes.
Cisapride is a drug that increases motility in the upper gastrointestinal tract and is used as a Gastroprokinetic. It acts directly as a serotonin 5-HT4 recepto...
SB269970 HCl is a hydrochloride salt form of SB-269970, which is a 5-HT7 receptor antagonist with pKi of 8.3, exhibits >50-fold selectivity against other recept...
Lisuride, an indoloquinoline derivative, has been found to be a dopamine D2 receptor agonist and could probably be effective in antimigraine as well as antipark...
Sarpogrelate is a drug under the development of Mitsubishi Chemical as 5HT2A and 5-HT2B receptor. antagonists. It is used as an antiplatelet agent and has been ...
8-OH-DPAT (8-Hydroxy-DPAT) is an agonist that has selectivity for 5-HT1A receptor (pIC50 = 8.19). It was subsequently found to be a serotonin reuptake inhibitor...
Rupatadine, with the potential to treat allergic rhinitis and urticaria, is a potent and long-lasting dual antagonist of PAF/H1. in vitro: Without affecting con...
Naratriptan, a 5-HT1B/1D receptor agonist, could be used in the treatment of migraine.
Quetiapine Fumarate is an atypical antipsychotic used in the treatment of schizophrenia, bipolar I mania, bipolar II depression, bipolar I depression.
Flibanserin, a benzimidazole derivative, has been found to be a Serotonin 1A/2A receptor agonist that was once studied as antidepressant as well as anxiolytic a...
Ferulic acid sodium
Ferulic acid sodium is one of the most abundant phenolic acids ubiquitously existing in plants. Free ferulic acid is a good antioxidant since it forms a resonan...
Loxapine Succinate is a D2DR and D4DR inhibitor, serotonergic receptor antagonist and also a dibenzoxazepine anti-psychotic agent.oxapine is a typical antipsych...
Dolasetron, a pseudopelletierine derivative, is a 5-HT3 receptor antagonist that could be used to relieve the nausea and vomiting caused by chemotherapy.
Granisetron is an antagonist of serptpmom 5-HT3 receptor and could be used to relieve the nausea and vomiting symptom after receving chemotherapy by decreasing ...
Bromperidol, a derivative of butyrophenone, is an antipsychotic commonly used in the treatment of schizophrenia as it could bind to the D2 dopamine and 5-HT2A s...
Iloperidone displays high affinity (Ki < 10 nM) for norepinephrine alpha(1)-adrenoceptors, dopamine D(3) and serotonin 5-HT(2A) receptors.