Eledoisin - CAS 69-25-0
Catalog number: 69-25-0
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Eledoisin is an undecapeptide of mollusk origin and it belongs to the tachykinin family of neuropeptides. It was first isolated from the posterior salivary glands of two mollusk species Eledone muschata and Eledone aldovandi. Eledoisin has the amino acid sequence pGlu-Pro-Ser-Lys-Asp-Ala-Phe-Ile-Gly-Leu-Met-NH2. It is the Potent natural tachykinin receptor ligand.
Publictions citing BOC Sciences Products
  • >> More
White lyophilised solid
eledonepeptide;ELEDOISIN;GLP-PRO-SER-LYS-ASP-ALA-PHE-ILE-GLY-LEU-MET-NH2;5-oxo-l-prolyl-l-prolyl-l-seryl-l-lysyl-l-aspartyl-l-alanyl-l-phenylalanyl-l-isoleucylglycyl-l-leucyl-l-methioninamide;PYR-PRO-SER-LYS-ASP-ALA-PHE-ILE-GLY-LEU-MET-NH2;PYR-PSKDAFIGLM;(3S)-3-[[(2S)-6-amino-2-[[(2S)-3-hydroxy-2-[[(2S)-1-[(2S)-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]propanoyl]amino]hexanoyl]amino]-4-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoic acid
Soluble to 0.20 mg/ml in water
-20℃ Freezer
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
1.289 g/cm3
Canonical SMILES:
1.Structural heterogeneity of doubly-charged peptide b-ions.
Li X1, Huang Y, O'Connor PB, Lin C. J Am Soc Mass Spectrom. 2011 Feb;22(2):245-54. doi: 10.1007/s13361-010-0036-1. Epub 2011 Jan 29.
Performing collisionally activated dissociation (CAD) and electron capture dissociation (ECD) in tandem has shown great promise in providing comprehensive sequence information that was otherwise unobtainable by using either fragmentation method alone or in duet. However, the general applicability of this MS(3) approach in peptide sequencing may be undermined by the formation of non-direct sequence ions, as sometimes observed under CAD, particularly when multiple stages of CAD are involved. In this study, varied-sized doubly-charged b-ions from three tachykinin peptides were investigated by ECD. Sequence scrambling was observed in ECD of all b-ions from neurokinin A (HKTDSFVGLM-NH(2)), suggesting the presence of N- and C-termini linked macro-cyclic conformers. On the contrary, none of the b-ions from eledoisin (pEPSKDAFIGLM-NH(2)) produced non-direct sequence ions under ECD, as it does not contain a free N-terminal amino group. ECD of several b-ions from Substance P (RPKPQQFFGLM-NH(2)) showed series of c(m)-Lys fragment ions which suggested that the macro-cyclic structure may also be formed by connecting the C-terminal carbonyl group and the ε-amino group of the lysine side chain.
2.Characterization of receptors for two Xenopus gastrointestinal tachykinin peptides in their species of origin.
Johansson A1, Liu L, Holmgren S, Burcher E. Naunyn Schmiedebergs Arch Pharmacol. 2004 Jul;370(1):35-45. Epub 2004 Jul 2.
Two tachykinin peptides, bufokinin and Xenopus neurokinin A (X-NKA) were recently isolated from Xenopus laevis. In this study we investigated the tachykinin receptors in the Xenopus gastrointestinal tract. In functional studies using stomach circular muscle strips, all peptides had similar potencies (EC50 values 1-7 nM). The rank order of potency to contract the intestine was physalaemin (EC50 1 nM)> or =bufokinin (EC50 3 nM)>substance P (SP)> or =cod SP>NKA>>X-NKA (EC50 1,900 nM). No maximum response could be obtained for [Sar9,Met(O2)11]SP, eledoisin and kassinin. In stomach strips, the mammalian tachykinin receptor antagonists RP 67580 (NK1) and MEN 10376 (NK2) had agonistic effects but did not antagonize bufokinin or X-NKA. In intestinal strips, RP 67580 (1 microM) reduced the maximal response to X-NKA but not bufokinin, while MEN 10376 was ineffective. [125I]BH-bufokinin bound with high affinity to a single class of sites, of KD 213+/-35 (stomach) and 172+/-9.
3.Eledoisin and Kassinin, but not Enterokassinin, stimulate ion transport in frog skin.
Lippe C1, Bellantuono V, Ardizzone C, Cassano G. Peptides. 2004 Nov;25(11):1971-5.
In frog skin, tachykinins stimulate the ion transport, estimated by measuring the short-circuit current (SCC) value, by interacting with NK1-like receptors. In this paper we show that Kassinin (NK2 preferring in mammals) increases the SCC, while Enterokassinin has no effect. Therefore, either 2 Pro residues or 1 Pro and 1 basic amino acid must be present in the part exceeding the C-terminal pentapeptide. Eledoisin (NK3 preferring in mammals) stimulation of SCC is reduced by CP99994 and SR48968 (NK1 and NK2 antagonists) and not affected by SB222200 (NK3 antagonist). None of the three antagonists affects Kassinin stimulation of SCC.
4.Iatrogenic dry eye disease: an eledoisin/carnitine and osmolyte drops study.
Nebbioso M1, Evangelista M, Librando A, Plateroti AM, Pescosolido N. Biomed Pharmacother. 2013 Sep;67(7):659-63. doi: 10.1016/j.biopha.2013.07.001. Epub 2013 Jul 12.
BACKGROUND: To evaluate the effects of an eye drop containing eledoisin and carnitine in patients suffering from primary open-angle glaucoma (POAG) and ocular discomfort syndrome secondary to a chronically treated with eye drops containing benzalkonium chloride (BAK) as preservative. The dry eye disease was defined as a multifactorial drop disease concerning tears and ocular surface, which brings to discomfort symptoms and visual disorders with potential damage to the ocular surface. Several studies underlined the beneficial effects of secretagogues drugs, such as eledoisin. It is a neuro-peptide extracted from the salivary glands of some shellfishes. Recently, it has been also showed the protective role of carnitine in respect of the ocular surface exposed to the tear film hyperosmolarity.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products

CAS 173352-39-1 Afobazole hydrochloride

Afobazole hydrochloride
(CAS: 173352-39-1)

Fabomotizole (brand name Afobazole) is an anxiolytic drug launched in Russia in the early 2000s. It produces anxiolytic and neuroprotective effects without any ...

CAS 355129-15-6 Eprotirome

(CAS: 355129-15-6)

Eprotirome is a synthetic thyroid hormone mimetic as a thyroid hormone receptor beta agonists, lowers total and low-density lipoprotein cholesterol up to 40% wi...

CAS 22494-42-4 Diflunisal

(CAS: 22494-42-4)

Diflunisal, a salicylic acid derivative, is a non-steroidal anti-inflammatory drug with analgesic and anti-inflammatory activity.

CAS 98753-19-6 Cefpirome Sulfate

Cefpirome Sulfate
(CAS: 98753-19-6)

Cefpirome Sulfate is a fourth generation cephalosporin antibiotic. It was developed by German company Hoechst and France Roussel company together.

CAS 125-03-1 Hydrocortamate hydrochloride

Hydrocortamate hydrochloride
(CAS: 125-03-1)

This active molecular is a synthetic glucocorticoid with immunosuppressive and anti-inflammatory properties. Hydrocortamate hydrochloride is applicated for the ...

CAS 78-28-4 Emylcamate

(CAS: 78-28-4)

Emylcamateis an anxiolytic and muscle relaxant. It can be used for the treatment of anxiety and tension.

CAS 55750-63-5 EMCS

(CAS: 55750-63-5)

ECMS is a useful protective group in antibody drug conjugates as a ADCs Linker.

CAS 11056-06-7 Bleomycin

(CAS: 11056-06-7)

Bleomycin is complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It forms complexes with iron that redu...

CAS 140898-91-5 Hexyl 5-aminolevulinate

Hexyl 5-aminolevulinate
(CAS: 140898-91-5)

CAS 103628-46-2 Sumatriptan

(CAS: 103628-46-2)

Sumatriptan is a Serotonin-1b and Serotonin-1d Receptor Agonist that acts selectively at 5HT1 receptors. It is a sulfonamide triptan with vasoconstrictor activi...

CAS 1613695-14-9 SGC-CBP30

(CAS: 1613695-14-9)

SGC-CBP30 is a potent and selective inhibitor of CREBBP (CBP) and EP300; which are general transcriptional co-activators. Mutations of CREBBP and EP300 lead to...

CAS 58546-56-8 Schisantherin A

Schisantherin A
(CAS: 58546-56-8)

Schisantherin A, source from the seeds of Schisandra chinensis (Turcz.) Baill., is a mechanism-based inhibitor that not only competitively inhibits but irrevers...

CAS 110642-44-9 Epmedin C

Epmedin C
(CAS: 110642-44-9)

Epmedin C, a lavonoids natural product extracted from Herbal Epimedium, has been found to have immunostimulatory and anticancer effect. It also has potential ac...

CAS 51-55-8 Atropine

(CAS: 51-55-8)

Atropine is an alkaloid as an nerve agent that occurs naturally in plants of the nightshade family.

CAS 10206-21-0 Cefacetrile

(CAS: 10206-21-0)

Cefacetrile, a derivative of 7-aminocephalosporanic acid, is a broad-spectrum first generation cephalosporin with antibiotic and antibacterial activity. It is e...

(CAS: 105424-59-7)

FR-900490 is a new type of immunoactive substance isolated from Disocia sp. F-11809. It is effective in reversing the damage to bone marrow caused by mitomycin ...

(CAS: 77573-44-5)

Ingenol-3,4:5,20-diacetonide is a natural compound extracted from the seeds of Euphorbia lathyris L. It is an analogue of Ingenol 3-Angelate.

CAS 1218942-37-0 GKT137831

(CAS: 1218942-37-0)

GKT137831 attenuates hypoxia-induced H(2)O(2) release, cell proliferation, and TGF-β1 expression and blunted reductions in PPARγ in HPAECs and HPASMCs.

Ritobegron ethyl hydrochloride
(CAS: 476333-91-2)

Ritobegron is a potential Bladder selectivity of the novel β₃-agonist.

CAS 370893-06-4 Ancriviroc

(CAS: 370893-06-4)

Ancriviroc, an oximino-piperidino-piperidine-amide, is a CCR5 receptor antagonist.

Chemical Structure

CAS 69-25-0 Eledoisin

Quick Inquiry

Verification code

Featured Items