Eleclazine - CAS 1443211-72-0
Catalog number: 1443211-72-0
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C21H16F3N3O3
Molecular Weight:
415.37
COA:
Inquire
Targets:
Sodium Channel
Description:
Eleclazine is a selective Sodium channel antagonist. Eleclazin showed a shortening of the QTc interval (the time interval between the start of the Q-wave and end of the T-wave in the heart’s electrical cycle) in patients with long QT-3 (LQT3) syndrome. Phase III clinical trilas for the treatment of Long QT syndrome, Phase II/III clinical trilas for the treatment of Hypertrophic cardiomyopathy and Phase II clinical trilas for the treatment of Ventricular arrhythmias are on-going.
Publictions citing BOC Sciences Products
  • >> More
Purity:
98%
Appearance:
Powder
Synonyms:
GS 6615; 4-[(pyrimidin-2-yl)methyl]-7-[4-(trifluoromethoxy)phenyl]- 3,4-dihydro-1,4-benzoxazepin-5(2H)-one
Solubility:
Soluble in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
Long QT syndrome;Hypertrophic cardiomyopathy;Ventricular arrhythmias
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
InChIKey:
YNUAEEJQYHYLMS-UHFFFAOYSA-N
InChI:
1S/C21H16F3N3O3/c22-21(23,24)30-16-5-2-14(3-6-16)15-4-7-18-17(12-15)20(28)27(10-11-29-18)13-19-25-8-1-9-26-19/h1-9,12H,10-11,13H2
Canonical SMILES:
c1cnc(nc1)CN2CCOc3ccc(cc3C2=O)c4ccc(cc4)OC(F)(F)F
Current Developer:
Originator Gilead Sciences
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Sodium Channel Products


CAS 536-43-6 Dyclonine Hydrochloride

Dyclonine Hydrochloride
(CAS: 536-43-6)

Dyclonine HCl is a hydrochloride salt form of dyclonine which is an oral anaesthetic.

CAS 5370-01-4 Mexiletine Hydrochloride

Mexiletine Hydrochloride
(CAS: 5370-01-4)

Mexiletine HCl belongs to Class IB anti-arrhythmic group of medicines, inhibits sodium channels to reduce the inward sodium current.

CAS 1315451-25-2 Nav1.7 blocker 24

Nav1.7 blocker 24
(CAS: 1315451-25-2)

Nav1.7 blocker 24 is a sodium channel blocker with selectivity for the voltage-gated Nav1.7 (pIC50 = 6.75).

CAS 2016-88-8 Amiloride HCl

Amiloride HCl
(CAS: 2016-88-8)

Amiloride HCl is a relatively selective inhibitor of the epithelial sodium channel (ENaC), used in the management of hypertension and congestive heart failure.

AZD-3161
(CAS: 1369501-46-1)

AZD 3161 is a Nav1.7-voltage-gated-sodium-channel-inhibitor originated by AstraZeneca. Phase-I clinical trials in Pain and Neuropathic pain was discontinued.

CAS 6108-05-0 Lidocaine hydrochloride monohydrate

Lidocaine hydrochloride monohydrate
(CAS: 6108-05-0)

Lidocaine hydrochloride monohydrate is the hydrochloride monohydrate form of lidocaine, which is an aminoethylamide and a prototypical member of the amide class...

CAS 1432913-36-4 GX-674

GX-674
(CAS: 1432913-36-4)

GX-674 is a Nav1.7 antagonist in the aryl sulfonamide class with higher selectivity for Nav1.7 (IC50= 0.1nM) over other Nav subtypes. Nav1.7 is commonly express...

CAS 4368-28-9 Tetrodotoxin

Tetrodotoxin
(CAS: 4368-28-9)

Tetrodotoxin, frequently abbreviated as TTX, is a potent neurotoxin. Its name derives from Tetraodontiformes, an order that includes pufferfish, porcupinefish, ...

VX-150

VX-150 is a NaV1.8 blocker which is currently in a phase II clinical trial for the treatment of patients with acute pain. Study shows that VX-150 significantly ...

CAS 31883-05-3 Moricizine

Moricizine
(CAS: 31883-05-3)

Moricizine, a Phenothiazine derivative, is effective in suppressing premature ventricular contractions, couplets, and nonsustained ventricular tachycardia. And ...

CAS 550-83-4 Propoxycaine hydrochloride

Propoxycaine hydrochloride
(CAS: 550-83-4)

Propoxycaine hydrochloride is the hydrochloride salt form of Propoxycaine used to control the pain of intramuscular injection of penicillin as well as in dentis...

CAS 84057-84-1 Lamotrigine

Lamotrigine
(CAS: 84057-84-1)

Lamotrigine is an anticonvulsant, inhibiting glutamate release, possibly through inhibition of Na+, K+ and Ca2+ currents.

CAS 298-46-4 Carbamazepine

Carbamazepine
(CAS: 298-46-4)

Carbamazepine (Carbatrol) is a sodium channel blocker with IC50 of 131 μM in rat brain synaptosomes.Carbamazepine (CBZ), first marketed under the tradename Tegr...

Nav1.7 inhibitor
(CAS: 1355631-24-1)

Nav1.7 inhibitor is a Voltage-gated sodium channel inhibitor that have probable effect in pain therapy and local anaesthesia.

CAS 396-01-0 Triamterene

Triamterene
(CAS: 396-01-0)

Triamterene blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner with IC50 of 4.5 μM.

CAS 50-12-4 Mephenytoin

Mephenytoin
(CAS: 50-12-4)

Mephenytoin is known to target sodium channel protein type 5 subunit alpha. It is a hydantoin-derivative anticonvulsant used to control various partial seizures...

GSK-1014802 hydrochloride
(CAS: 934240-31-0)

GSK-1014802 hydrochloride is the hydrochloride form of GSK-1014802, which is a novel analgesic for the treatment of lumbosacral radiculopathy (sciatica) and tri...

CAS 74517-78-5 Indecainide

Indecainide
(CAS: 74517-78-5)

Indecainide is a Sodium channel antagonists originated by Eli Lilly. Treatment for Arrhythmias and Ventricular arrhythmias was discontinued.

CAS 28721-07-5 Oxcarbazepine

Oxcarbazepine
(CAS: 28721-07-5)

Oxcarbazepine inhibits the binding of [3H]BTX to sodium channels with IC50 of 160 μM and also inhibits the influx of 22Na+ into rat brain synaptosomes with IC50...

CAS 6160-12-9 (-)-Sparteine sulfate pentahydrate

(-)-Sparteine sulfate pentahydrate
(CAS: 6160-12-9)

(-)-Sparteine sulfate pentahydrate is an alkaloid compound which could be used as in the treatment of antiarrhythmic by blocking sodium channel.

Quick Inquiry

Verification code

Featured Items