Eleclazine - CAS 1443211-72-0
Catalog number:
1443211-72-0
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C21H16F3N3O3
Molecular Weight:
415.37
COA:
Inquire
Targets:
Sodium Channel
Description:
Eleclazine is a selective Sodium channel antagonist. Eleclazin showed a shortening of the QTc interval (the time interval between the start of the Q-wave and end of the T-wave in the heart’s electrical cycle) in patients with long QT-3 (LQT3) syndrome. Phase III clinical trilas for the treatment of Long QT syndrome, Phase II/III clinical trilas for the treatment of Hypertrophic cardiomyopathy and Phase II clinical trilas for the treatment of Ventricular arrhythmias are on-going.
Publictions citing BOC Sciences Products
  • >> More
Purity:
98%
Appearance:
Powder
Synonyms:
GS 6615; 4-[(pyrimidin-2-yl)methyl]-7-[4-(trifluoromethoxy)phenyl]- 3,4-dihydro-1,4-benzoxazepin-5(2H)-one
Solubility:
Soluble in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
Long QT syndrome;Hypertrophic cardiomyopathy;Ventricular arrhythmias
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
InChIKey:
YNUAEEJQYHYLMS-UHFFFAOYSA-N
InChI:
1S/C21H16F3N3O3/c22-21(23,24)30-16-5-2-14(3-6-16)15-4-7-18-17(12-15)20(28)27(10-11-29-18)13-19-25-8-1-9-26-19/h1-9,12H,10-11,13H2
Canonical SMILES:
c1cnc(nc1)CN2CCOc3ccc(cc3C2=O)c4ccc(cc4)OC(F)(F)F
Current Developer:
Originator Gilead Sciences
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Sodium Channel Products


CAS 536-43-6 Dyclonine Hydrochloride

Dyclonine Hydrochloride
(CAS: 536-43-6)

Dyclonine HCl is a hydrochloride salt form of dyclonine which is an oral anaesthetic.

CAS 132112-35-7 Ropivacaine Hydrochloride

Ropivacaine Hydrochloride
(CAS: 132112-35-7)

Ropivacaine hydrochloride is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly.

CAS 1234365-97-9 Tenapanor HCl

Tenapanor HCl
(CAS: 1234365-97-9)

Tenapanor, also known as AZD-1722 and RDX 5791, is a first-in-class, small-molecule inhibitor of the gastrointestinal sodium/hydrogen exchanger NHE3. Tenapanor ...

CAS 57-41-0 Phenytoin

Phenytoin
(CAS: 57-41-0)

Phenytoin is believed to protect against seizures by causing voltage-dependent block of voltage gated sodium channels.

CAS 944261-79-4 A-803467

A-803467
(CAS: 944261-79-4)

A-803467 is a sodium channel blocker that potently blocks tetrodotoxin-resistant currents (IC50=140 nM).

CAS 22059-60-5 Disopyramide phosphate

Disopyramide phosphate
(CAS: 22059-60-5)

Disopyramide phosphate is an oral antiarrhythmic agent for the treatment of cardiac arrhythmias. Disopyramide is a sodium channel blocker and therefore classifi...

PF-05241328
(CAS: 1387633-03-5)

PF-05241328, a purely acidic molecule, is a selective inhibitor of human Nav1. 7 voltage-dependent sodium channels (IC50= 31nM) for the treatment of pain. But P...

XEN907
(CAS: 912656-34-9)

XEN907 is a novel spirooxindole NaV1.7 blocker with IC50 of 3 nM. It shows a further 10-fold increase in potency, which represents a promising structure for fur...

CAS 66794-74-9 Encainide Hydrochloride

Encainide Hydrochloride
(CAS: 66794-74-9)

Encainide Hydrochloride is a sodium channel blocker and class Ic antiarrhythmic agent. It is a non-chiral and benzanilide derivative. It blocks voltage-gated so...

AM-36
(CAS: 199467-52-2)

AM-36 is a potent blocker of batrachotoxinin (BTX)-sensitive Na+ channel binding in rat brain homogenates with an IC50 of 0.28 microM. As a unique neuroprotecti...

CAS 42971-09-5 Vinpocetine

Vinpocetine
(CAS: 42971-09-5)

Vinpocetine is a Phosphodiesterase inhibitor and selective for PDE1. It also blocks voltage-gated Na+ channels.

CAS 159138-80-4 Cariporide

Cariporide
(CAS: 159138-80-4)

Cariporide, also known as HOE-642, is a selectiveNa+/H+exchange inhibitor, also known as the Na+/H+ antiporter, which functions to improve cellular integrity fo...

Funapide
(CAS: 1259933-16-8)

Funapide is a Nav1.7 and Nav1.8 voltage-gated sodium channel inhibitor under the development by Xenon Pharmaceuticals and Teva Pharmaceutical Industries. It is ...

CAS 630-93-3 Phenytoin Sodium

Phenytoin Sodium
(CAS: 630-93-3)

Phenytoin Sodium is a potent multi-channel blocker, which blocks Na+, K+ and Ca 2+ channels and selectively blocks persistent INaP over shorter INaP actions.

CAS 550-83-4 Propoxycaine hydrochloride

Propoxycaine hydrochloride
(CAS: 550-83-4)

Propoxycaine hydrochloride is the hydrochloride salt form of Propoxycaine used to control the pain of intramuscular injection of penicillin as well as in dentis...

CAS 212778-82-0 Elpetrigine

Elpetrigine
(CAS: 212778-82-0)

Elpetrigine, also known as GW 273293 and JZP-4, has a blocking effect on calcium channels and potassium channels which has been in clinical bipolar disorders an...

PF-04856264
(CAS: 1235397-05-3)

This active molecular is a human Nav1.7 voltage gated sodium channel inhibitor with the IC50 value of 28 nM. PF-04856264 inhibits the Nav channel by interacting...

CAS 84057-84-1 Lamotrigine

Lamotrigine
(CAS: 84057-84-1)

Lamotrigine is an anticonvulsant, inhibiting glutamate release, possibly through inhibition of Na+, K+ and Ca2+ currents.

CAS 85-79-0 Dibucaine

Dibucaine
(CAS: 85-79-0)

Dibucaine is an anesthetic of the amide type. It is mainly used for surface anesthesia and now restricted to use in spinal and topical anesthesia. It reduced th...

PD 122860
(CAS: 122576-86-7)

This active molecular is a calcium channel antagonist with sodium channel stimulating property as a dihydropyridine. PD 122860 can increase left ventricular con...

Quick Inquiry

Verification code

Featured Items