Eldacimibe - CAS 141993-70-6
Catalog number: 141993-70-6
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C39H58N2O5
Molecular Weight:
634.89
COA:
Inquire
Targets:
Others
Description:
Eldacimibe is a Sterol O-acyltransferase inhibitor originated by Wyeth. No development was reported for Atherosclerosis and Hypercholesterolaemia in USA.
Purity:
98%
Appearance:
Powder
Synonyms:
ACA 147; ANA 147; WAY 125147; WAY ACA 147; 1,3-Dioxane-4,6-dione, 5-(((3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)amino)(((4-(2,2-dimethylpropyl)phenyl)-methyl)hexylamino)methylene-2,2-dimethyl
Solubility:
Soluble in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
Atherosclerosis; Hypercholesterolaemia
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
InChIKey:
HGLFNRGXRCKGSW-UHFFFAOYSA-N
InChI:
1S/C39H58N2O5/c1-13-14-15-16-21-41(25-27-19-17-26(18-20-27)24-36(2,3)4)33(31-34(43)45-39(11,12)46-35(31)44)40-28-22-29(37(5,6)7)32(42)30(23-28)38(8,9)10/h17-20,22-23,40,42H,13-16,21,24-25H2,1-12H3
Canonical SMILES:
c1c(N\C(=C2/C(OC(OC2=O)(C)C)=O)N(Cc2ccc(cc2)CC(C)(C)C)CCCCCC)cc(c(c1C(C)(C)C)O)C(C)(C)C
Current Developer:
Originator Wyeth
1.Prospects for drug therapy for hyperlipoproteinaemia.
Davignon J Diabete Metab. 1995 Apr;21(2):139-46.
Prospects for therapy for hyperlipoproteinaemia are likely to rely more heavily on improvement of known molecules than on development of new ones aimed at various components of the plasma lipid transport system. Promising advances are revealed in both directions. A new synthetic inhibitor of HMG CoA reductase, atorvastatin, lowers plasma low-density lipoprotein (LDL)-cholesterol and triglycerides and increases high-density lipoprotein (HDL)-cholesterol with greater potency than currently available drugs of this class. A highly selective thyromimetic, CGS 26214, virtually devoid of cardiovascular effects, has potent cholesterol-lowering activity in several models, reduces post-prandial response to a fat load in rats and markedly lowers Lp(a) concentrations in monkeys. There is a trend to develop inhibitors of acyl CoA: cholesterol acyltransferase (ACAT) with more than one desirable activity. Thus, ACA-147, which inhibits cholesterol absorption, reduces LDL, prevents their oxidation and increases HDL-cholesterol, was antiatherogenic in cholesterol-fed rabbits. Sch48461 has emerged as an inhibitor of cholesterol absorption by an as yet unknown mechanism unrelated to ACAT inhibition, while a synthetic saponin, CP- 148,623, which prevents the entry of cholesterol into intestinal mucosa, has a potential for combination therapy.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


CAS 107767-58-8 A-802715

A-802715
(CAS: 107767-58-8)

A802715, a methylxanthine derivative, is an anti-tumor agent with a TD50 (toxic dose of 50%) of 0.9-1.1 mM.

CAS 126985-97-5 Locustatachykinin I

Locustatachykinin I
(CAS: 126985-97-5)

Insect tachykinin-related peptide (TRP) isolated from Locusta migratoria. Exhibits sequence homology with vertebrate tachykinins.

CAS 508-02-1 Oleanolic Acid

Oleanolic Acid
(CAS: 508-02-1)

Oleanolic Acid is a non-toxic, hepatoprotective triterpenoid found in Phytolacca Americana, which exerts antitumor and antiviral properties.

CAS 38976-17-9 α-Tocopherol phosphate

α-Tocopherol phosphate
(CAS: 38976-17-9)

alpha-Tocopherol is the compound demonstrating the highest vitamin E activity, which is available both in its natural form as RRR-alpha-tocopherol isolated from...

PROTO-1
(CAS: 312951-85-2)

PROTO-1, a benzothiophene carboxamide, shows significant protection of hair cells over a broad range of neomycin concentrations, from 25 μM to 400 μM.

CAS 1222780-33-7 TPPU

TPPU
(CAS: 1222780-33-7)

TTPU is a soluble epoxide hydrolase inhibitor (sEHI) (IC50= 37, 2.8 nM and 3.7 nM for monkey, mouse and human sEH, respectively) with anti-inflammatory, anti-hy...

CAS 81907-62-2 Ganoderic acid A

Ganoderic acid A
(CAS: 81907-62-2)

Ganoderic acids are a class of related triterpenoids found in Ganoderma mushrooms. Now ganoderic acid A and ganoderic acid B are well characterized. Some ganode...

CAS 483-63-6 Crotamiton

Crotamiton
(CAS: 483-63-6)

Crotamiton is a general antipruritic agent for treating scabies.

Chemical Structure

CAS 141993-70-6 Eldacimibe

Quick Inquiry

Verification code

Featured Items