|Description||Elamipretide is a cardiolipin peroxidase inhibitor and mitochondria-targeting peptide under the development of Stealth BioTherapeutics. It can Improve left Ventricular and Mitochondrial Function. Elamipretide can alleviate mitochondrial dysfunction and oxidative damage in human trabecular meshwork cells. It can prevent both iHTM and GTM(3) cells from sustained oxidative stress induced by H(2)O(2). Phase II clinical trials for the treatment of Chronic heart failure and Mitochondrial myopathies are ongoing.|
|Synonyms||Bendavia; ELA 4; MTP 131; Ocuvia; SBT-31; SPI-31; SS-31;(S)-6-amino-N-((S)-1-amino-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-((R)-2-amino-5-guanidinopentanamido)-3-(4-hydroxy-2,6-dimethylphenyl)propanamido)hexanamide|
|Solubility||DMSO: ≥ 29 mg/mL|
|Application||Chronic heart failure; Mitochondrial myopathies|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Current Developer||Stealth BioTherapeutics|
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