Elamipretide - CAS 736992-21-5
Catalog number:
736992-21-5
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C32-H49-N9-O5
Molecular Weight:
639.80
COA:
Inquire
Targets:
Others
Description:
Elamipretide is a cardiolipin peroxidase inhibitor and mitochondria-targeting peptide under the development of Stealth BioTherapeutics. It can Improve left Ventricular and Mitochondrial Function. Elamipretide can alleviate mitochondrial dysfunction and oxidative damage in human trabecular meshwork cells. It can prevent both iHTM and GTM(3) cells from sustained oxidative stress induced by H(2)O(2). Phase II clinical trials for the treatment of Chronic heart failure and Mitochondrial myopathies are ongoing.
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Purity:
98%
Appearance:
Powder
Synonyms:
Bendavia; ELA 4; MTP 131; Ocuvia; SBT-31; SPI-31; SS-31;(S)-6-amino-N-((S)-1-amino-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-((R)-2-amino-5-guanidinopentanamido)-3-(4-hydroxy-2,6-dimethylphenyl)propanamido)hexanamide
Solubility:
DMSO: ≥ 29 mg/mL
Storage:
-20℃ Freezer
MSDS:
Inquire
Application:
Chronic heart failure; Mitochondrial myopathies
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
InChIKey:
SFVLTCAESLKEHH-WKAQUBQDSA-N
InChI:
1S/C32H49N9O5/c1-19-15-22(42)16-20(2)23(19)18-27(41-29(44)24(34)11-8-14-38-32(36)37)31(46)39-25(12-6-7-13-33)30(45)40-26(28(35)43)17-21-9-4-3-5-10-21/h3-5,9-10,15-16,24-27,42H,6-8,11-14,17-18,33-34H2,1-2H3,(H2,35,43)(H,39,46)(H,40,45)(H,41,44)(H4,36,37,38)/t24-,25+,26+,27+/m1/s1
Canonical SMILES:
Cc1cc(cc(c1C[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccccc2)C(=O)N)NC(=O)[C@@H](CCCNC(=N)N)N)C)O
Current Developer:
Stealth BioTherapeutics
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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