Eicosapentaenoic Acid - CAS 10417-94-4
Catalog number:
10417-94-4
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C20H30O2
Molecular Weight:
302.45
COA:
Inquire
Targets:
Others
Description:
Eicosapentaenoic acid (EPA) is an omega-3 fatty acid.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
MSDS:
Inquire
1.Synthesis of the Conjugated Trienes 5E,7E,9E,14Z,17Z Eicosapentaenoic Acid and 5Z,7E,9E,14Z,17Z Eicosapentaenoic Acid, and Their Induction of Apoptosis in DLD-1 Colorectal Adenocarcinoma Cells
Tsuyoshi Tsuzuki, Kazumi Tanaka, Shigefumi Kuwahara, and Teruo Miyazawa,* Lipids, Vol. 40, no. 2 (2005)
To identify the specific cytotoxic FA, we have synthesized possible candidates for the active species. Here, we report the synthesis of (5E,7E,9E,14Z,17Z)-5,7,9,14,17-eicosapentaenoic acid (E-CEPA, Scheme 1) and its 5-(Z) isomer (Z-CEPA, Scheme. 1), which both exist naturally in the red alga (Ptilota filicina J. Agardh). We then examined the cytotoxicity of these molecules in human tumor cells and confirmed that both isomers have strong bioactivity.
2.Accumulation of Eicosapentaenoic Acid in Membranes of Erythrocytes and Leukocytes during Alterative-Exudative and Allergic Inflammation
N. M. Shilina, O. N. Komarova, F. A. Medvedev, M. I. Dubrovskaya*, and I. Ya. Kon’. Bulletin of Experimental Biology and Medicine, Vol. 149, No. 5, 2010
The composition of fatty acids in erythrocyte membranes from healthy children was characterized by prevalence of w6-family arachidonic acid (AA) and high content of 蠅3-family docosahexaenoic acid (DHA; relative to the amount of polyunsaturated fatty acids). The contents of AA (20:4) and DHA (22:6) decreased sharply, while the amount of eicosapentaenoic acid (EPA; 20:5) of the w3 family increased significantly in IDGIT patients (Table 1; Fig. 1, a). These changes were observed in IDGIT patients with normal body weight and obesity (Table 1; Fig. 1, a). Therefore, severe metabolic changes during obesity do not affect the composition of cell membrane fatty acids under conditions of inflammation. Changes in the amount of fatty acids in erythrocyte membranes were followed by variations in some indexes for the state of membranes. The EPA/DHA ratio in membranes was significantly elevated during inflammation (12.8 vs. 3.2 in healthy donors).
3.Seasonal Transfer of the Pool of the Essential Eicosapentaenoic Acid along the Pelagic Trophic Chain of a Eutrophic Reservoir
N. N. Sushchik, M. I. Gladyshev, O. N. Makhutova. Doklady Biological Sciences, 2008, Vol. 422, pp. 355–356.
It is known that not only the amount of produced and consumed organic matter, but also its quality, i.e., its elementary and biochemical composition are important for functioning of trophic chains. In the past two decades, it has been demonstrated that interaction between producers and primary consumers (phyto- and zooplankton) in pelagic ecosystems substantially depends on the phytoplankton content of the essential eicosapentaenoic acid (20:5 w3, EPA). It is believed that the EPA content of seston, which ultimately determines the efficiency of interaction between trophic links, inversely depends on the trophicity level of water ecosystems. This statement is based on the analysis of summer phytoplankton, which is known to be mainly represented by diatom, cryptophyte, and other EPArich microalgae in oligotrophic water bodies, whereas cyanobacteria incapable of synthesizing this fatty acid dominate eutrophic water bodies.
4.Eicosapentaenoic acid increases lipolysis through up-regulation of the lipolytic gene expression and down-regulation of the adipogenic gene expression in 3T3-L1 adipocytes
Mak-Soon Lee, In-Sook Kwun, Yangha Kim. Genes Nutr (2008) 2:327–330
In the present study, we investigated the effects of eicosapentaenoic acid (EPA), known as one of the most critical components of n-3 PUFA, on lipid metabolism and the underlying mechanisms in 3T3-L1 adipocytes. We hypothesize that EPA stimulates lipolysis through induction of lipolytic gene expression and suppression of adipogenic gene expression. We measured the lipid accumulation and release of free fatty acids (FFAs) and glycerol into medium followed by EPA treatment. In addition, the mRNA levels of the adipogenic genes including peroxisome proliferator-activated receptor-c (PPAR-c) and acetyl-CoA carboxylase (ACC), and carnitine palmitoyltransferase I-a (CPT-Ia), one of lipolytic genes, were measured.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


CAS 519-37-9 Etofylline

Etofylline
(CAS: 519-37-9)

β-hydroxyethyltheophylline is an inhibitor of 3’,5’-Cyclic Nucleotide Phosphodiesterase.

CAS 69-25-0 Eledoisin

Eledoisin
(CAS: 69-25-0)

Eledoisin is an undecapeptide of mollusk origin and it belongs to the tachykinin family of neuropeptides. It was first isolated from the posterior salivary glan...

CAS 189003-92-7 Trelanserin

Trelanserin
(CAS: 189003-92-7)

Trelanserin is a serotonin receptor antagonist.

AT-1459
(CAS: 294658-50-7)

AT-1459 is a novel, direct thrombin inhibitor with antithrombotic efficacy (Ki = 4.9 nM).

CAS 13721-39-6 Sodium orthovanadate

Sodium orthovanadate
(CAS: 13721-39-6)

Sodium orthovanadate is an alkaline phosphatase and (Na,K)-ATPase inhibitor with IC50 of 10 μM.

Finerenone
(CAS: 1050477-31-0)

Finerenone is a non-steroidal antimineralocorticoid. It has less relative affinity to other steroid hormone receptors than currently available, which should res...

CAS 6199-67-3 Cucurbitacin B

Cucurbitacin B
(CAS: 6199-67-3)

Cucurbitacin B, an oxygenated tetracyclic triterpenoid compound extracted from Cucurbitaceae plant species, is a long-term anticancer agent by disruption of mic...

CAS 1613695-14-9 SGC-CBP30

SGC-CBP30
(CAS: 1613695-14-9)

SGC-CBP30 is a potent and selective inhibitor of CREBBP (CBP) and EP300; which are general transcriptional co-activators. Mutations of CREBBP and EP300 lead to...

CAS 518-69-4 Corydaline

Corydaline
(CAS: 518-69-4)

Corydaline, extracted from Corydalis ambigua, is one of the major active constituents in a new prokinetic botanical agent exhibiting the antiacetylcholinesteras...

LY 135114
(CAS: 126254-82-8)

LY 135114 is a metabolite of LY 195448. LY195448 is a Alpha adrenergic receptor originate by Eli Lilly. But clinical trials for the treatment of cancer had been...

CAS 94-25-7 Butyl 4-aminobenzoate

Butyl 4-aminobenzoate
(CAS: 94-25-7)

Butyl 4-aminobenzoate acts as a long-duration local anesthetic. It aids in treatment of chronic pain. It is also known to induce anti-nociception effects in sub...

CAS 1203956-47-1 11β-HSD1-IN-1

11β-HSD1-IN-1
(CAS: 1203956-47-1)

11β-HSD1-IN-1 is an inhibitor of 11β-hydroxydehydrogenase 1 (11β-HSD1) (IC50= 52 nM).

CAS 23964-57-0 Articaine hydrochloride

Articaine hydrochloride
(CAS: 23964-57-0)

Articaine is a dental amide-type local anesthetic. It is the most widely used local anesthetic in a number of European countries and is available in many countr...

CAS 157283-66-4 (+)-Cloprostenol isopropyl ester

(+)-Cloprostenol isopropyl ester
(CAS: 157283-66-4)

(+)-Cloprostenol isopropyl ester is a derivative of cloprostenol which has been found to be a FP receptor agonist as well as a luteolytic agent and could be use...

PBTZ169
(CAS: 1377239-83-2)

PBTZ169 is a decaprenyl-phosphoribose-epimerase (DprE1) inhibitor. DprE1 is an essential enzyme involved in the cell wall biosynthesis of Corynebacterineae. The...

CAS 100646-51-3 Quizalofop-p-ethyl

Quizalofop-p-ethyl
(CAS: 100646-51-3)

Quizalofop-P-ethyl, a quinoxaline derivative, is a sort of post-emergence herbicide that might be effective in regulating annual and perennial grass weeds.

CAS 315704-66-6 PTC-209

PTC-209
(CAS: 315704-66-6)

CAS 118-60-5 2-Ethylhexyl salicylate

2-Ethylhexyl salicylate
(CAS: 118-60-5)

2-Ethylhexyl salicylate could be commonly used in cosmetics and sunscreens acting as a skin penetration enhancer and could absorb UVB rays at some extent.

CAS 132836-42-1 YS-49

YS-49
(CAS: 132836-42-1)

Anti-inflammatory agent; Antithrombotic; Antiplatelet; YS-49 protects cells from oxidant injury; induces heme oxygenase (HO-1) in endothelial cells and protects...

CAS 179599-82-7 Lotrafiban hydrochloride

Lotrafiban hydrochloride
(CAS: 179599-82-7)

The hydrochloride salt form of Lotrafiban, a benzodiazepine derivative, has been found to be a platelet glycoprotein IIb/IIIa blocker and was once studied in ca...

Chemical Structure

CAS 10417-94-4 Eicosapentaenoic Acid

Quick Inquiry

Verification code

Featured Items